Martin Egli

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 62

Top Topics

Top Venues

Nucleic acids research

Organic letters

RNA (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Rachana Tomar, Songlin Li, Martin Egli, Michael P Stone
Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η. Biochemistry 63 (6) (2024)
Rachana Tomar, Songlin Li, Martin Egli, Michael P Stone
Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η. Biochemistry 63 (6) (2024)
Rachana Tomar, Songlin Li, Martin Egli, Michael P Stone
Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η. Biochemistry (2024)
Juan Carvajal-Garcia, Harrison Bracey, Anna E Johnson, Angel J Hernandez Viera, Martin Egli, Esra N Simsek, Emily A Jaremba, Kwangho Kim, Houra Merrikh
A small molecule that inhibits the evolution of antibiotic resistance. NAR molecular medicine 1 (1) (2024)
Adrian Humboldt, Fabian Rami, Franka M Topp, Dejana Arnold, Daniela Göhringer, Pradeep S Pallan, Martin Egli, Clemens Richert
Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity. Angewandte Chemie (International ed. in English) 63 (15) (2024)
Rachana Tomar, Songlin Li, Martin Egli, Michael P Stone
Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η. Biochemistry 63 (6) (2024)
Rachana Tomar, Pratibha P Ghodke, Amritraj Patra, Elizabeth Smyth, Alexander Pontarelli, William Copp, Frederick Peter Guengerich, John C Chaput, Christopher J Wilds, Michael P Stone, Martin Egli
DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η. Biochemistry (2024)
Juan Carvajal-Garcia, Harrison Bracey, Anna E Johnson, Angel J Hernandez Viera, Martin Egli, Esra N Simsek, Emily A Jaremba, Kwangho Kim, Houra Merrikh
A small molecule that inhibits the evolution of antibiotic resistance. NAR molecular medicine 1 (1) (2024)
Adrian Humboldt, Fabian Rami, Franka M Topp, Dejana Arnold, Daniela Göhringer, Pradeep S Pallan, Martin Egli, Clemens Richert
Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity. Angewandte Chemie (International ed. in English) 63 (15) (2024)
Adrian Humboldt, Fabian Rami, Franka M Topp, Dejana Arnold, Daniela Göhringer, Pradeep S Pallan, Martin Egli, Clemens Richert
Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity. Angewandte Chemie (International ed. in English) (2024)
Adrian Humboldt, Fabian Rami, Franka M Topp, Dejana Arnold, Daniela Göhringer, Pradeep S Pallan, Martin Egli, Clemens Richert
Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity. Angewandte Chemie (International ed. in English) 63 (15) (2024)
Li Lei, Joel M Harp, John C Chaput, Kelly Wassarman, Mark K Schlegel, Muthiah Manoharan, Martin Egli
Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Current protocols 4 (6) (2024)
Rachana Tomar, Songlin Li, Martin Egli, Michael P Stone
Replication Bypass of the N -(2-Deoxy-d-erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η. Biochemistry 63 (6) (2024)
Juan Carvajal-Garcia, Harrison Bracey, Anna E Johnson, Angel J Hernandez Viera, Martin Egli, Esra N Simsek, Emily A Jaremba, Kwangho Kim, Houra Merrikh
A small molecule that inhibits the evolution of antibiotic resistance. NAR molecular medicine 1 (1) (2024)
Juan Carvajal-Garcia, Harrison Bracey, Anna E Johnson, Angel J Hernandez Viera, Martin Egli, Esra N Simsek, Emily A Jaremba, Kwangho Kim, Houra Merrikh
A small molecule that inhibits the evolution of antibiotic resistance. NAR molecular medicine 1 (1) (2024)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Rachana Tomar, Irina G Minko, Pankaj Sharma, Andrew H Kellum, Li Lei, Joel M Harp, T M Iverson, R Stephen Lloyd, Martin Egli, Michael P Stone
Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase. Nucleic acids research (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Dhrubajyoti Datta, Christopher S Theile, Kelly Wassarman, June Qin, Tim Racie, Karyn Schmidt, Yongfeng Jiang, Rachel Sigel, Maja M Janas, Martin Egli, Muthiah Manoharan
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical communications (Cambridge, England) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic ( S )-glycol nucleic acid ( S -GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency. RNA (New York, N.Y.) 29 (4) (2023)
Pradeep S Pallan, Terry P Lybrand, Eriks Rozners, Mikhail Abramov, Guy Schepers, Elena Eremeeva, Piet Herdwijn, Martin Egli
Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry. Biochemistry (2023)
Martin Egli, Mark K Schlegel, Muthiah Manoharan
Acyclic (S)-Glycol Nucleic Acid (S-GNA) Modification of siRNAs Improves the Safety of RNAi Therapeutics While Maintaining Potency. RNA (New York, N.Y.) (2023)
Atanu Ghosh, Masaaki Akabane-Nakata, Jayanta Kundu, Joel M Harp, Mimouna Madaoui, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Properties of Phosphorodiamidate Piperidino Oligomers. Organic letters 25 (6) (2023)
Martin Egli
Robert Letsinger and the Evolution of Oligonucleotide Synthesis. ACS omega 8 (36) (2023)
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Lauren Woods, Joel M Harp, Jason A Gilbert, Anna Bisbe, Rajar M Manoharan, MaryBeth Kim, Christopher S Theile, Dale C Guenther, Yongfeng Jiang, Saket Agarwal, Rajanikanth Maganti, Mark K Schlegel, Ivan Zlatev, Klaus Charisse, Kallanthottathil G Rajeev, Adam Castoreno, Martin Maier, Maja M Janas, Martin Egli, John C Chaput, Muthiah Manoharan
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. Journal of the American Chemical Society (2023)
Martin Egli, Muthiah Manoharan
Chemistry, structure and function of approved oligonucleotide therapeutics. Nucleic acids research (2023)
Dhrubajyoti Datta, Christopher S Theile, Kelly Wassarman, June Qin, Tim Racie, Karyn Schmidt, Yongfeng Jiang, Rachel Sigel, Maja M Janas, Martin Egli, Muthiah Manoharan
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex. Chemical communications (Cambridge, England) 59 (42) (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Arnab Das, Atanu Ghosh, Jayanta Kundu, Martin Egli, Muthiah Manoharan, Surajit Sinha
Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs. The Journal of organic chemistry (2023)
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L S Willoughby, Nate Taneja, Jonathan O'Shea, Anna Bisbe, Rajar M Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K Nair, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Martin Egli, Muthiah Manoharan
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways. Journal of medicinal chemistry 66 (4) (2023)
Andrew H Kellum, Pradeep S Pallan, Arman Nilforoushan, Shana J Sturla, Michael P Stone, Martin Egli
Conformation and Pairing Properties of an O 6 -Methyl-2'-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA. Chemical research in toxicology 35 (10) (2022)
Dale C Guenther, Shohei Mori, Shigeo Matsuda, Jason A Gilbert, Jennifer L S Willoughby, Sarah Hyde, Anna Bisbe, Yongfeng Jiang, Saket Agarwal, Mimouna Madaoui, Maja M Janas, Klaus Charisse, Martin A Maier, Martin Egli, Muthiah Manoharan
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β- C -methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects. Journal of the American Chemical Society 144 (32) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Shuguang Zhang, Martin Egli
Hiding in plain sight: three chemically distinct α -helix types. Quarterly reviews of biophysics 55 (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Joel M Harp, Terry P Lybrand, Pradeep S Pallan, Leighton Coates, Brendan Sullivan, Martin Egli
Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure. Nucleic acids research 50 (13) (2022)
Mimouna Madaoui, Dhrubajyoti Datta, Kelly Wassarman, Ivan Zlatev, Martin Egli, Bruce S Ross, Muthiah Manoharan
A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups. Organic letters 24 (33) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Gloria E O Borgstahl, William B O'Dell, Martin Egli, Jan F Kern, Andrey Y Kovalevsky, Jiao Y Y Lin, Dean Myles, Mark A Wilson, Wen Zhang, Petrus Zwart, Leighton Coates
EWALD: A macromolecular diffractometer for the second target station. The Review of scientific instruments 93 (6) (2022)
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization. Nucleic acids research 50 (12) (2022)
Joel M Harp, Leighton Coates, Brendan Sullivan, Martin Egli
Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography. Nucleic acids research 49 (8) (2021)
Masaaki Akabane-Nakata, Tyler Chickering, Joel M Harp, Mark K Schlegel, Shigeo Matsuda, Martin Egli, Muthiah Manoharan
RNAs Containing Carbocyclic Ribonucleotides. Organic letters 24 (2) (2021)
Mark K Schlegel, Shigeo Matsuda, Christopher R Brown, Joel M Harp, Joseph D Barry, Daniel Berman, Adam Castoreno, Sally Schofield, John Szeto, Muthiah Manoharan, Klaus Charissé, Martin Egli, Martin A Maier
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Nucleic acids research 49 (19) (2021)
Hartmut Jahns, Nate Taneja, Jennifer L S Willoughby, Masaaki Akabane-Nakata, Christopher R Brown, Tuyen Nguyen, Anna Bisbe, Shigeo Matsuda, Matt Hettinger, Rajar M Manoharan, Kallanthottathil G Rajeev, Martin A Maier, Ivan Zlatev, Klaus Charisse, Martin Egli, Muthiah Manoharan
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo. Nucleic acids research (2021)
Christopher Liczner, Kieran Duke, Gabrielle Juneau, Martin Egli, Christopher J Wilds
Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications. Beilstein journal of organic chemistry 17 (2021)
Hartmut Jahns, Rohan Degaonkar, Peter Podbevsek, Swati Gupta, Anna Bisbe, Krishna Aluri, John Szeto, Pawan Kumar, Sarah LeBlanc, Tim Racie, Christopher R Brown, Adam Castoreno, Dale C Guenther, Vasant Jadhav, Martin A Maier, Janez Plavec, Martin Egli, Muthiah Manoharan, Ivan Zlatev
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing. Nucleic acids research 49 (18) (2021)
Umesh K Mishra, Yogesh S Sanghvi, Martin Egli, Namakkal G Ramesh
Supramolecular Architecture through Self-Organization of Janus-Faced Homoazanucleosides. The Journal of organic chemistry 86 (1) (2020)
Pradeep S Pallan, Terry P Lybrand, Mark K Schlegel, Joel M Harp, Hartmut Jahns, Muthiah Manoharan, Martin Egli
Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost. Biochemistry 59 (49) (2020)
Masaaki Akabane-Nakata, Pawan Kumar, Rajat S Das, Namrata D Erande, Shigeo Matsuda, Martin Egli, Muthiah Manoharan
Synthesis and Biophysical Characterization of RNAs Containing 2'-Fluorinated Northern Methanocarbacyclic Nucleotides. Organic letters 21 (7) (2019)
Martin Egli, Terry P Lybrand
Enhanced Dispersion and Polarization Interactions Achieved through Dithiophosphate Group Incorporation Yield a Dramatic Binding Affinity Increase for an RNA Aptamer-Thrombin Complex. Journal of the American Chemical Society 141 (10) (2019)
Martin Egli, Muthiah Manoharan
Re-Engineering RNA Molecules into Therapeutic Agents. Accounts of chemical research 52 (4) (2019)
Joel M Harp, Leighton Coates, Brendan Sullivan, Martin Egli
Cryo-neutron crystallographic data collection and preliminary refinement of left-handed Z-DNA d(CGCGCG). Acta crystallographica. Section F, Structural biology communications 74 (Pt 10) (2018)
Martin Egli
Architecture and mechanism of the central gear in an ancient molecular timer. Journal of the Royal Society, Interface 14 (128) (2017)
Yan Su, Martin Egli, Frederick Peter Guengerich
Human DNA polymerase η accommodates RNA for strand extension. The Journal of biological chemistry 292 (44) (2017)