John C Chaput (John J Chaput)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 52

Top Topics

Structural Basis

Gene Expression

Circulating Tumor

Top Venues

ACS synthetic biology

Journal of the American Chemical Society

Nature communications

Nucleic acids research

This page only lists publications with an associated author ORCID identifier.

Publications

Bhawna Barpuzary, Sergey Negria, John C Chaput
Improved synthesis and polymerase recognition of 7-deaza-7-modified α-l-threofuranosyl guanosine analogs. RSC advances 14 (28) (2024)
Rachana Tomar, Pratibha P Ghodke, Amritraj Patra, Elizabeth Smyth, Alexander Pontarelli, William Copp, Frederick Peter Guengerich, John C Chaput, Christopher J Wilds, Michael P Stone, Martin Egli
DNA Replication across α-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase η. Biochemistry (2024)
Bhawna Barpuzary, Sergey Negria, John C Chaput
Improved synthesis and polymerase recognition of 7-deaza-7-modified α-l-threofuranosyl guanosine analogs. RSC advances 14 (28) (2024)
Kim Nguyen, Turnee N Malik, John C Chaput
Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. Nature communications 14 (1) (2023)
Adriana Lozoya-Colinas, Yutong Yu, John C Chaput
Functionally Enhanced XNA Aptamers Discovered by Parallelized Library Screening. Journal of the American Chemical Society (2023)
Kim Nguyen, Turnee N Malik, John C Chaput
Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. Nature communications 14 (1) (2023)
Erica M Lee, Noah A Setterholm, Mohammad Hajjar, Bhawna Barpuzary, John C Chaput
Stability and mechanism of threose nucleic acid toward acid-mediated degradation. Nucleic acids research (2023)
Kim Nguyen, Turnee N Malik, John C Chaput
Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. Nature communications 14 (1) (2023)
Kim Nguyen, Turnee N Malik, John C Chaput
Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. Nature communications 14 (1) (2023)
E J Yik, E Medina, Brian M Paegel, John C Chaput
Highly Parallelized Screening of Functionally Enhanced XNA Aptamers in Uniform Hydrogel Particles. ACS synthetic biology (2023)
Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Lauren Woods, Joel M Harp, Jason A Gilbert, Anna Bisbe, Rajar M Manoharan, MaryBeth Kim, Christopher S Theile, Dale C Guenther, Yongfeng Jiang, Saket Agarwal, Rajanikanth Maganti, Mark K Schlegel, Ivan Zlatev, Klaus Charisse, Kallanthottathil G Rajeev, Adam Castoreno, Martin Maier, Maja M Janas, Martin Egli, John C Chaput, Muthiah Manoharan
Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs. Journal of the American Chemical Society (2023)
Nandini Kundu, Cailen M McCloskey, Mohammad Hajjar, John C Chaput
Parameterizing the Binding Properties of XNA Aptamers Isolated from a Low Stringency Selection. Biochemistry (2023)
Biju Majumdar, Daisy Sarma, Yutong Yu, Adriana Lozoya-Colinas, John C Chaput
Increasing the functional density of threose nucleic acid. RSC chemical biology 5 (1) (2023)
Kefan Yang, John C Chaput
Amplification-Free COVID-19 Detection by Digital Droplet REVEALR. ACS synthetic biology (2023)
Kim Nguyen, Turnee N Malik, John C Chaput
Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity. Nature communications 14 (1) (2023)
Biju Majumdar, Daisy Sarma, Yutong Yu, Adriana Lozoya-Colinas, John C Chaput
Increasing the functional density of threose nucleic acid. RSC chemical biology 5 (1) (2023)
Kefan Yang, John C Chaput
Amplification-Free COVID-19 Detection by Digital Droplet REVEALR. ACS synthetic biology (2023)
Mohammad Hajjar, Nicholas Chim, Chao Liu, Piet Herdwijn, John C Chaput
Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid. Nucleic acids research 50 (17) (2022)
Kefan Yang, Daniel N Schuder, Arlene K Ngor, John C Chaput
REVEALR-Based Genotyping of SARS-CoV-2 Variants of Concern in Clinical Samples. Journal of the American Chemical Society 144 (26) (2022)
Robert C Spitale, John C Chaput
Reply to: On gene silencing by the X10-23 DNAzyme. Nature chemistry 14 (8) (2022)
John C Chaput
Redesigning the Genetic Polymers of Life. Accounts of chemical research 54 (4) (2021)
Cailen M McCloskey, Qingfeng Li, Eric J Yik, Nicholas Chim, Arlene K Ngor, Esau Medina, Ivan Grubisic, Lance Co Ting Keh, Ryan Poplin, John C Chaput
Evolution of Functionally Enhanced α-l-Threofuranosyl Nucleic Acid Aptamers. ACS synthetic biology 10 (11) (2021)
Qingfeng Li, Victoria A Maola, Nicholas Chim, Javeena Hussain, Adriana Lozoya-Colinas, John C Chaput
Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities. Journal of the American Chemical Society 143 (42) (2021)
Nicholas Chim, Roman A Meza, Anh M Trinh, Kefan Yang, John C Chaput
Following replicative DNA synthesis by time-resolved X-ray crystallography. Nature communications 12 (1) (2021)
Esau Medina, Eric J Yik, Piet Herdwijn, John C Chaput
Functional Comparison of Laboratory-Evolved XNA Polymerases for Synthetic Biology. ACS synthetic biology 10 (6) (2021)
Yajun Wang, Xiaolin Liu, Mouhamad Shehabat, Nicholas Chim, John C Chaput
Transliteration of synthetic genetic enzymes. Nucleic acids research 49 (20) (2021)
Yajun Wang, Kim Nguyen, Robert C Spitale, John C Chaput
A biologically stable DNAzyme that efficiently silences gene expression in cells. Nature chemistry 13 (4) (2021)
Kefan Yang, John C Chaput
REVEALR: A Multicomponent XNAzyme-Based Nucleic Acid Detection System for SARS-CoV-2. Journal of the American Chemical Society 143 (24) (2021)
Kim Nguyen, Yajun Wang, Whitney E England, John C Chaput, Robert C Spitale
Allele-Specific RNA Knockdown with a Biologically Stable and Catalytically Efficient XNAzyme. Journal of the American Chemical Society 143 (12) (2021)
Matthew R Dunn, Cailen M McCloskey, Patricia Buckley, Katherine Rhea, John C Chaput
Generating Biologically Stable TNA Aptamers that Function with High Affinity and Thermal Stability. Journal of the American Chemical Society 142 (17) (2020)
Li Zhang, John C Chaput
In Vitro Selection of an ATP-Binding TNA Aptamer. Molecules (Basel, Switzerland) 25 (18) (2020)
John C Chaput, Piet Herdewijn, Marcel Hollenstein
Orthogonal Genetic Systems. Chembiochem : a European journal of chemical biology 21 (10) (2020)
Ali Nikoomanzar, Derek Vallejo, Eric J Yik, John C Chaput
Programmed Allelic Mutagenesis of a DNA Polymerase with Single Amino Acid Resolution. ACS synthetic biology 9 (7) (2020)
Ali Nikoomanzar, Nicholas Chim, Eric J Yik, John C Chaput
Engineering polymerases for applications in synthetic biology. Quarterly reviews of biophysics 53 (2020)
Kefan Yang, Cailen M McCloskey, John C Chaput
Reading and Writing Digital Information in TNA. ACS synthetic biology 9 (11) (2020)
David P Horning, Saikat Bala, John C Chaput, Gerald F Joyce
RNA-Catalyzed Polymerization of Deoxyribose, Threose, and Arabinose Nucleic Acids. ACS synthetic biology 8 (5) (2019)
Ali Nikoomanzar, Derek Vallejo, John C Chaput
Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning. ACS synthetic biology 8 (6) (2019)
Jen-Yu Liao, Saikat Bala, Arlene K Ngor, Eric J Yik, John C Chaput
P(V) Reagents for the Scalable Synthesis of Natural and Modified Nucleoside Triphosphates. Journal of the American Chemical Society 141 (34) (2019)
Derek Vallejo, Ali Nikoomanzar, Brian M Paegel, John C Chaput
Fluorescence-Activated Droplet Sorting for Single-Cell Directed Evolution. ACS synthetic biology 8 (6) (2019)
John C Chaput, Piet Herdwijn
What Is XNA? Angewandte Chemie (International ed. in English) 58 (34) (2019)
Cailen M McCloskey, Jen-Yu Liao, Saikat Bala, John C Chaput
Ligase-Mediated Threose Nucleic Acid Synthesis on DNA Templates. ACS synthetic biology 8 (2) (2019)
Yajun Wang, Alexander Vorperian, Mouhamad Shehabat, John C Chaput
Evaluating the Catalytic Potential of a General RNA-Cleaving FANA Enzyme. Chembiochem : a European journal of chemical biology 21 (7) (2019)
Saikat Bala, Jen-Yu Liao, Li Zhang, Chantel N Tran, Nicholas Chim, John C Chaput
Synthesis of 2'-Deoxy-α-l-threofuranosyl Nucleoside Triphosphates. The Journal of organic chemistry 83 (16) (2018)
Yajun Wang, Arlene K Ngor, Ali Nikoomanzar, John C Chaput
Evolution of a General RNA-Cleaving FANA Enzyme. Nature communications 9 (1) (2018)
Hui Mei, Jen-Yu Liao, Randi M Jimenez, Yajun Wang, Saikat Bala, Cailen McCloskey, Christopher Switzer, John C Chaput
Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues. Journal of the American Chemical Society 140 (17) (2018)
John C Chaput
Visualizing primer extension without enzymes. eLife 7 (2018)
Nicholas Chim, Lynnette N Jackson, Anh M Trinh, John C Chaput
Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. eLife 7 (2018)
Aaron W Feldman, Emil C Fischer, Michael P Ledbetter, Jen-Yu Liao, John C Chaput, Floyd E Romesberg
A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria. Journal of the American Chemical Society 140 (4) (2018)
Ali Nikoomanzar, Matthew R Dunn, John C Chaput
Evaluating the Rate and Substrate Specificity of Laboratory Evolved XNA Polymerases. Analytical chemistry 89 (23) (2017)
Saikat Bala, Jen-Yu Liao, Hui Mei, John C Chaput
Synthesis of α-l-Threofuranosyl Nucleoside 3'-Monophosphates, 3'-Phosphoro(2-Methyl)imidazolides, and 3'-Triphosphates. The Journal of organic chemistry 82 (11) (2017)
Nicholas Chim, Changhua Shi, Sujay P Sau, Ali Nikoomanzar, John C Chaput
Structural basis for TNA synthesis by an engineered TNA polymerase. Nature communications 8 (1) (2017)
Sujay P Sau, John C Chaput
A Gram-Scale HPLC-Free Synthesis of TNA Triphosphates Using an Iterative Phosphorylation Strategy. Organic letters 19 (16) (2017)