R Scott Lokey

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 21

Top Topics

Molecular Dynamics Simulations

Respiratory Syndrome Coronavirus

Crystal Structure

Top Venues

Journal of the American Chemical Society

Journal of medicinal chemistry

Proceedings of the National Academy of Sciences of the United States of America

Journal of chemical information and modeling

This page only lists publications with an associated author ORCID identifier.

Publications

Justin H Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F T Koehler, Christian N Cunningham, R Scott Lokey
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society 146 (7) (2024)
Justin H Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F T Koehler, Christian N Cunningham, R Scott Lokey
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society 146 (7) (2024)
Justin H Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F T Koehler, Christian N Cunningham, R Scott Lokey
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society (2024)
Justin H Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F T Koehler, Christian N Cunningham, R Scott Lokey
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society 146 (7) (2024)
Justin H Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F T Koehler, Christian N Cunningham, R Scott Lokey
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society 146 (7) (2024)
Justin H Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F T Koehler, Christian N Cunningham, R Scott Lokey
Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation. Journal of the American Chemical Society 146 (7) (2024)
Pan-Pan Zhang, Grant Koch, Yankun Zhang, Kevin Yang, R Scott Lokey
DNA-Compatible Conditions for the Formation of N -Methyl Peptide Bonds. ACS omega 8 (26) (2023)
Suzie K Hight, Trevor N Clark, Kenji L Kurita, Elizabeth A McMillan, Walter Bray, Anam F Shaikh, Aswad S Khadilkar, F P Jake Haeckl, Fausto Carnevale-Neto, Scott La, Akshar Lohith, Rachel M Vaden, Jeon Lee, Shuguang Wei, R Scott Lokey, Michael A White, Roger G Linington, John B MacMillan
High-throughput functional annotation of natural products by integrated activity profiling. Proceedings of the National Academy of Sciences of the United States of America 119 (49) (2022)
Christopher van Hoorebeke, Kevin Yang, Samuel J Mussetter, Grant Koch, Natalie Rutz, R Scott Lokey, Phillip Crews, Theodore R Holman
Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity. ACS omega 7 (47) (2022)
Thomas Stadelmann, Govindan Subramanian, Sanjay Menon, Chad E Townsend, R Scott Lokey, Marc-Olivier Ebert, Sereina Riniker
Connecting the conformational behavior of cyclic octadepsipeptides with their ionophoric property and membrane permeability. Organic & biomolecular chemistry 18 (36) (2022)
Victoria G Klein, Adam G Bond, Conner Craigon, R Scott Lokey, Alessio Ciulli
Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. Journal of medicinal chemistry (2021)
Victoria G Klein, Walter M Bray, Hao-Yuan Wang, Quinn Edmondson, Joshua Schwochert, Satoshi Ono, Matthew R Naylor, Alexandra C Turmon, Justin H Faris, Okimasa Okada, Jack Taunton, R Scott Lokey
Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives. ACS chemical biology 16 (8) (2021)
Satoshi Ono, Matthew R Naylor, Chad E Townsend, Chieko Okumura, Okimasa Okada, Hsiau-Wei Lee, R Scott Lokey
Cyclosporin A: Conformational Complexity and Chameleonicity. Journal of chemical information and modeling 61 (11) (2021)
Akihiro Furukawa, Joshua Schwochert, Cameron R Pye, Daigo Asano, Quinn D Edmondson, Alexandra C Turmon, Victoria G Klein, Satoshi Ono, Okimasa Okada, R Scott Lokey
Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity. Angewandte Chemie (International ed. in English) 59 (48) (2020)
Alejandro R Foley, Graham P Roseman, Ka Chan, Amanda Smart, Thomas S Finn, Kevin Yang, R Scott Lokey, Glenn L Millhauser, Jevgenij A Raskatov
Evidence for aggregation-independent, PrPC-mediated Aβ cellular internalization. Proceedings of the National Academy of Sciences of the United States of America 117 (46) (2020)
Colin N Kelly, Chad E Townsend, Ajay N Jain, Matthew R Naylor, Cameron R Pye, Joshua Schwochert, R Scott Lokey
Geometrically Diverse Lariat Peptide Scaffolds Reveal an Untapped Chemical Space of High Membrane Permeability. Journal of the American Chemical Society 143 (2) (2020)
Satoshi Ono, Matthew R Naylor, Chad E Townsend, Chieko Okumura, Okimasa Okada, R Scott Lokey
Conformation and Permeability: Cyclic Hexapeptide Diastereomers. Journal of chemical information and modeling 59 (6) (2019)
Matthew R Naylor, Andrew M Ly, Mason J Handford, Daniel P Ramos, Cameron R Pye, Akihiro Furukawa, Victoria G Klein, Ryan P Noland, Quinn Edmondson, Alexandra C Turmon, William M Hewitt, Joshua Schwochert, Chad E Townsend, Colin N Kelly, Maria-Jesus Blanco, R Scott Lokey
Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility. Journal of medicinal chemistry 61 (24) (2018)
Cameron R Pye, William M Hewitt, Joshua Schwochert, Terra D Haddad, Chad E Townsend, Lyns Etienne, Yongtong Lao, Chris Limberakis, Akihiro Furukawa, Alan M Mathiowetz, David A Price, Spiros Liras, R Scott Lokey
Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules. Journal of medicinal chemistry 60 (5) (2017)
Hana Martucci, Scott E Campit, Stephanie R Gee, Walter M Bray, Trevor Gokey, A King Cada, Ten-Yang Yen, Katsuhiko Minoura, Anton B Guliaev, R Scott Lokey, Taro Amagata
Naphthablins B and C, Meroterpenoids Identified from the Marine Sediment-Derived Streptomyces sp. CP26-58 Using HeLa Cell-Based Cytological Profiling. Journal of natural products 80 (3) (2017)
Markus Boehm, Kevin Beaumont, Rhys Jones, Amit S Kalgutkar, Liying Zhang, Karen Atkinson, Guoyun Bai, Janice A Brown, Heather Eng, Gilles H Goetz, Brian R Holder, Bhagyashree Khunte, Sarah Lazzaro, Chris Limberakis, Sangwoo Ryu, Michael J Shapiro, Laurie Tylaska, Jiangli Yan, Rushia Turner, Siegfried S F Leung, Mahesh Ramaseshan, David A Price, Spiros Liras, Matthew P Jacobson, David J Earp, R Scott Lokey, Alan M Mathiowetz, Elnaz Menhaji-Klotz
Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators. Journal of medicinal chemistry 60 (23) (2017)