Matthew P Jacobson (Matt Jacobson)

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 27

Top Venues

Biochemistry

Nature

Journal of medicinal chemistry

Blood

UCSF

Massachusetts Institute of Technology (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

UCSF

United States

Professor :: Pharmaceutical Chemistry

Education History

Massachusetts Institute of Technology

United States

PHD :: Chemistry

Stanford University

United States

BSC :: Chemistry

Publications

Ariel Leyte-Vidal, Diego Garrido Ruiz, RosaAnna DeFilippis, Inga B Leske, Delphine Rea, Stacey Phan, Kaeli B Miller, Feifei Hu, Anjeli Mase, Yibing Shan, Oliver Hantschel, Matthew P Jacobson, Neil P Shah
BCR::ABL1 Kinase N-lobe Mutants Confer Moderate to High Degrees of Resistance to Asciminib. Blood (2024)
Ariel Leyte-Vidal, Diego Garrido Ruiz, RosaAnna DeFilippis, Inga B Leske, Delphine Rea, Stacey Phan, Kaeli B Miller, Feifei Hu, Anjeli Mase, Yibing Shan, Oliver Hantschel, Matthew P Jacobson, Neil P Shah
BCR::ABL1 Kinase N-lobe Mutants Confer Moderate to High Degrees of Resistance to Asciminib. Blood (2024)
Kyle P Kisor, Diego Garrido Ruiz, Matthew P Jacobson, Diane L Barber
A role for pH dynamics regulating transcription factor DNA binding selectivity. bioRxiv : the preprint server for biology (2024)
Ariel Leyte-Vidal, Diego Garrido Ruiz, RosaAnna DeFilippis, Inga B Leske, Delphine Rea, Stacey Phan, Kaeli B Miller, Feifei Hu, Anjeli Mase, Yibing Shan, Oliver Hantschel, Matthew P Jacobson, Neil P Shah
BCR::ABL1 kinase N-lobe mutants confer moderate to high degrees of resistance to asciminib. Blood 144 (6) (2024)
Shahid Rehan, Dale Tranter, Phillip P Sharp, Gregory B Craven, Eric Lowe, Janet L Anderl, Tony Muchamuel, Vahid Abrishami, Suvi Kuivanen, Nicole A Wenzell, Andy Jennings, Chakrapani Kalyanaraman, Tomas Strandin, Matti Javanainen, Olli Vapalahti, Matthew P Jacobson, Dustin McMinn, Christopher J Kirk, Juha T Huiskonen, Jack Taunton, Ville O Paavilainen
Signal peptide mimicry primes Sec61 for client-selective inhibition. Nature chemical biology (2023)
Jonathan D Paolino, Boris Dimitrov, Beth Apsel Winger, Angélica Sandoval-Pérez, Amith Vikram Rangarajan, Nicole Ocasio-Martinez, Harrison K Tsai, Yuting Li, Amanda L Robichaud, Delan Khalid, Charles Hatton, Riaz Gillani, Petri Polonen, Anthony Dilig, Giacomo Gotti, Julia Kavanagh, Asmani A Adhav, Sean Gow, Jonathan M Tsai, Yen-Der Li, Benjamin L Ebert, Eliezer Van Allen, Jacob R Bledsoe, Annette S Kim, Sarah K Tasian, Stacy L Cooper, Todd M Cooper, Nobuko Hijiya, Maria-Luisa Sulis, Neerav N Shukla, Jeffrey A Magee, Charles G Mullighan, Michael J Burke, Marlise R Luskin, Brenton G Mar, Matthew P Jacobson, Marian H Harris, Kimberly Stegmaier, Andrew E Place, Yana Pikman
Integration of genomic sequencing drives therapeutic targeting of PDGFRA in T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Elissa A Fink, Jun Xu, Harald Hübner, Joao M Braz, Philipp Seemann, Charlotte Avet, Veronica Craik, Dorothée Weikert, Maximilian F Schmidt, Chase M Webb, Nataliya A Tolmachova, Yurii S Moroz, Xi Ping Huang, Chakrapani Kalyanaraman, Stefan Gahbauer, Geng Chen, Zheng Liu, Matthew P Jacobson, John J Irwin, Michel Bouvier, Yang Du, Brian K Shoichet, Allan I Basbaum, Peter Gmeiner
Structure-based discovery of nonopioid analgesics acting through the α 2A -adrenergic receptor. Science (New York, N.Y.) 377 (6614) (2022)
Xiaoxiao Sun, Jake M Bieber, Heinz Hammerlindl, Robert J Chalkley, Kathy H Li, Alma L Burlingame, Matthew P Jacobson, Lani F Wu, Steven J Altschuler
Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters. Science advances 8 (4) (2022)
Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli, Juan Lorenzo Pablo, Ying Dong, Setu M Vora, Longfei Wang, Tian-Min Fu, Matthew P Jacobson, Anna Greka, Judy Lieberman, Jianbin Ruan, Hao Wu
Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature 593 (7860) (2021)
Parnian Lak, Henry O'Donnell, Xuewen Du, Matthew P Jacobson, Brian K Shoichet
A Crowding Barrier to Protein Inhibition in Colloidal Aggregates. Journal of medicinal chemistry 64 (7) (2021)
Wan-Chen Tsai, Ansari Mukhtar Aleem, Chris Whittington, Wilian A Cortopassi, Chakrapani Kalyanaraman, Angel Baroz, Anthony T Iavarone, Ewa Skrzypczak-Jankun, Matthew P Jacobson, Adam R Offenbacher, Theodore R Holman
Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase. Biochemistry 60 (10) (2021)
Wan-Chen Tsai, Chakrapani Kalyanaraman, Adriana Yamaguchi, Michael Holinstat, Matthew P Jacobson, Theodore R Holman
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry 60 (22) (2021)
Svetlana A Kholodar, Geoffrey Lang, Wilian A Cortopassi, Yoshie Iizuka, Harman S Brah, Matthew P Jacobson, Pamela M England
Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1. ACS chemical biology 16 (7) (2021)
Mausam Kalita, Javier Villanueva-Meyer, Yuki Ohkawa, Chakrapani Kalyanaraman, Katharine Chen, Esraa Mohamed, Matthew F L Parker, Matthew P Jacobson, Joanna J Phillips, Kenneth W Bayles, David M Wilson
Synthesis and Screening of α-Xylosides in Human Glioblastoma Cells. Molecular pharmaceutics 18 (1) (2020)
Cody Freedman, Adrianne Tran, Benjamin E Tourdot, Chakrapani Kalyanaraman, Steve Perry, Michael Holinstat, Matthew P Jacobson, Theodore R Holman
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. Biochemistry 59 (19) (2020)
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M White, Matthew J O'Meara, Veronica V Rezelj, Jeffrey Z Guo, Danielle L Swaney, Tia A Tummino, Ruth Hüttenhain, Robyn M Kaake, Alicia L Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J Polacco, Hannes Braberg, Jacqueline M Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J Bennett, Merve Cakir, Michael J McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T Kirby, James E Melnyk, John S Chorba, Kevin Lou, Shizhong A Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J P Mathy, Tina Perica, Kala Bharath Pilla, Sai J Ganesan, Daniel J Saltzberg, Ramachandran Rakesh, Xi Liu, Sara Brin Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, José M Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A Wankowicz, Markus Bohn, Maliheh Safari, Fatima S Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J Fletcher, Michael C O'Neal, Yiming Cai, Jason C J Chang, David J Broadhurst, Saker Klippsten, Phillip P Sharp, Nicole A Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, Raphael Trenker, Janet M Young, Devin A Cavero, Joseph Hiatt, Theodore L Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M Stroud, Alan D Frankel, Oren S Rosenberg, Kliment A Verba, David A Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark Von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe D'Enfert, Shaeri Mukherjee, Matthew P Jacobson, Harmit Singh Malik, Danica G Fujimori, Trey Ideker, Charles S Craik, Stephen N Floor, Brian K Shoichet, John D Gross, Andrej Sali, Bryan L Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M Shokat, Brian K Shoichet, Nevan J Krogan
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583 (7816) (2020)
Steven C Perry, Thomas Horn, Benjamin E Tourdot, Adriana Yamaguchi, Chakrapani Kalyanaraman, William S Conrad, Oluwayomi Akinkugbe, Michael Holinstat, Matthew P Jacobson, Theodore R Holman
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. Biochemistry 59 (42) (2020)
Qi Li, Jenna Pellegrino, D John Lee, Arthur A Tran, Hector A Chaires, Ruoxi Wang, Jesslyn E Park, Kaijie Ji, David Chow, Na Zhang, Axel F Brilot, Justin T Biel, Gydo van Zundert, Kenneth Borrelli, Dean Shinabarger, Cindy Wolfe, Beverly Murray, Matthew P Jacobson, Estelle Mühle, Olivier Chesneau, Brian K Shoichet, Ian B Seiple
Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature 586 (7827) (2020)
Victoria J Butler, Fuying Gao, Christian I Corrales, Wilian A Cortopassi, Benjamin Caballero, Mihir Vohra, Kaveh Ashrafi, Ana Maria Cuervo, Matthew P Jacobson, Giovanni Coppola, Aimee W Kao
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. PLoS genetics 15 (8) (2019)
Ansari Mukhtar Aleem, Wan-Chen Tsai, Jennyfer Tena, Gabriella Alvarez, Joshua Deschamps, Chakrapani Kalyanaraman, Matthew P Jacobson, Theodore R Holman
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. Biochemistry 58 (6) (2019)
Victoria J Butler, Wilian A Cortopassi, Sushmitha Gururaj, Austin L Wang, Olivia M Pierce, Matthew P Jacobson, Aimee W Kao
Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro. Biochemistry 58 (23) (2019)
Paola Bisignano, Chiara Ghezzi, Hyunil Jo, Nicholas F Polizzi, Thorsten Althoff, Chakrapani Kalyanaraman, Rosmarie Friemann, Matthew P Jacobson, Ernest M Wright, Michael Grabe
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters. Nature communications 9 (1) (2018)
Hao Shao, Xiaokai Li, Michael A Moses, Luke A Gilbert, Chakrapani Kalyanaraman, Zapporah T Young, Margarita Chernova, Sara N Journey, Jonathan S Weissman, Byron Hann, Matthew P Jacobson, Len Neckers, Jason E Gestwicki
Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). Journal of medicinal chemistry 61 (14) (2018)
Hai L Tran, Katrina W Lexa, Olivier Julien, Travis S Young, Christopher T Walsh, Matthew P Jacobson, James A Wells
Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. Journal of the American Chemical Society 139 (7) (2017)
Katharine A White, Diego Garrido Ruiz, Zachary Alfano Szpiech, Nicolas B Strauli, Ryan D Hernandez, Matthew P Jacobson, Diane L Barber
Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins. Science signaling 10 (495) (2017)
Felipe de Jesus Cortez, Phuong Nguyen, Charles Truillet, Boxue Tian, Kristopher M Kuchenbecker, Michael J Evans, Paul Webb, Matthew P Jacobson, Robert J Fletterick, Pamela M England
Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. ACS chemical biology 12 (12) (2017)
Markus Boehm, Kevin Beaumont, Rhys Jones, Amit S Kalgutkar, Liying Zhang, Karen Atkinson, Guoyun Bai, Janice A Brown, Heather Eng, Gilles H Goetz, Brian R Holder, Bhagyashree Khunte, Sarah Lazzaro, Chris Limberakis, Sangwoo Ryu, Michael J Shapiro, Laurie Tylaska, Jiangli Yan, Rushia Turner, Siegfried S F Leung, Mahesh Ramaseshan, David A Price, Spiros Liras, Matthew P Jacobson, David J Earp, R Scott Lokey, Alan M Mathiowetz, Elnaz Menhaji-Klotz
Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators. Journal of medicinal chemistry 60 (23) (2017)

Matthew P Jacobson.css-eqlu8i{font-size:small;padding-left:4px;} (Matt Jacobson)

Publication Activity (10 Years)

Top Topics

Top Venues

Matthew P Jacobson (Matt Jacobson)