Richard T Pomerantz

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 29

Top Venues

Nature communications

Nature structural & molecular biology

bioRxiv : the preprint server for biology

RNA (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T Pomerantz, Tomasz Skorski
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa L Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S Chen, Richard T Pomerantz
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T Pomerantz, Tomasz Skorski
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Nature communications 15 (1) (2024)
Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T Pomerantz, Tomasz Skorski
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa L Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S Chen, Richard T Pomerantz
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A Khant, Richard T Pomerantz, Xiaojiang S Chen
Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining. bioRxiv : the preprint server for biology (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A Khant, Richard T Pomerantz, Xiaojiang S Chen
Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining. bioRxiv : the preprint server for biology (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A Khant, Richard T Pomerantz, Xiaojiang S Chen
Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining. bioRxiv : the preprint server for biology (2024)
Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T Pomerantz, Tomasz Skorski
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa L Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S Chen, Richard T Pomerantz
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nature communications 15 (1) (2024)
John J Krais, David J Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G Betsch, Andrea J Bernhardy, Alice M Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T Pomerantz, Gaorav P Gupta, Joseph R Testa, Neil Johnson
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities. Nature communications 14 (1) (2023)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Author Correction: Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology (2023)
Marissa L Calbert, Gurushankar Chandramouly, Clare M Adams, Magali Saez-Ayala, Tatiana Kent, Mrityunjay Tyagi, V S S Abhinav Ayyadevara, Yifan Wang, John J Krais, John Gordon, Jessica Atkins, Monika Maria Toma, Stéphane Betzi, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Aaron R Goldman, Nicole Gorman, Ramkrishna Mitra, Wayne E Childers, Xavier Graña, Tomasz Skorski, Neil Johnson, Christian Hurtz, Xavier Morelli, Christine M Eischen, Richard T Pomerantz
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress. Molecular cancer therapeutics (2023)
Taylor N Tredinnick, Tatiana Kent, Leonid Minakhin, Ziyuan Li, Jozef Madzo, Xiaojiang S Chen, Richard T Pomerantz
Promoter-Independent Synthesis of Chemically Modified RNA by Polymerase θ Variants. RNA (New York, N.Y.) (2023)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology (2022)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology 30 (1) (2022)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology 30 (1) (2022)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology 30 (1) (2022)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology 30 (1) (2022)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology (2022)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology 30 (1) (2022)
Gurushankar Chandramouly, Joonas A Jamsen, Nikita Borisonnik, Mrityunjay Tyagi, Marissa L Calbert, Taylor Tredinnick, Ahmet Y Ozdemir, Tatiana Kent, Elena V Demidova, Sanjeevani Arora, Samuel H Wilson, Richard T Pomerantz
Polλ promotes microhomology-mediated end-joining. Nature structural & molecular biology (2022)
Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor N Tredinnick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba A Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M Stark, Xiaojiang S Chen, Richard T Pomerantz
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair. Science advances 7 (24) (2021)
Tatiana Kent, Pedro A Mateos-Gomez, Agnel Sfeir, Richard T Pomerantz
Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining. eLife 5 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Richard T Pomerantz