Xiaojiang S Chen

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 43

Top Topics

Structural Basis

Electron Microscopy

Top Venues

Nature communications

Science advances

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Fumiaki Ito, Hanjing Yang, Z Hong Zhou, Xiaojiang S Chen
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein & cell 15 (7) (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa L Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S Chen, Richard T Pomerantz
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
Fumiaki Ito, Hanjing Yang, Z Hong Zhou, Xiaojiang S Chen
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein & cell 15 (7) (2024)
George S Karagiannis, Josue Pacheco, Kyumin Kim, Diako Ebrahimi, Fumiaki Ito, Xiaojiang S Chen
Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain. bioRxiv : the preprint server for biology (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa L Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S Chen, Richard T Pomerantz
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nature communications 15 (1) (2024)
Fumiaki Ito, Hanjing Yang, Z Hong Zhou, Xiaojiang S Chen
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein & cell 15 (7) (2024)
George S Karagiannis, Josue Pacheco, Kyumin Kim, Diako Ebrahimi, Fumiaki Ito, Xiaojiang S Chen
Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain. bioRxiv : the preprint server for biology (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A Khant, Richard T Pomerantz, Xiaojiang S Chen
Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining. bioRxiv : the preprint server for biology (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
Fumiaki Ito, Hanjing Yang, Z Hong Zhou, Xiaojiang S Chen
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. Protein & cell 15 (7) (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Hanjing Yang, Josue Pacheco, Kyumin Kim, Diako Ebrahimi, Fumiaki Ito, Xiaojiang S Chen
Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain. bioRxiv : the preprint server for biology (2024)
Jared M Sagendorf, Raktim Mitra, Jiawei Huang, Xiaojiang S Chen, Remo Rohs
PNAbind: Structure-based prediction of protein-nucleic acid binding using graph neural networks. bioRxiv : the preprint server for biology (2024)
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor N Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J Krais, Yifan Wang, Umeshkumar M Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S Chen, Richard T Pomerantz
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A Khant, Richard T Pomerantz, Xiaojiang S Chen
Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining. bioRxiv : the preprint server for biology (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Htet A Khant, Richard T Pomerantz, Xiaojiang S Chen
Structural Basis for Polθ-Helicase DNA Binding and Microhomology-Mediated End-Joining. bioRxiv : the preprint server for biology (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes. Nature communications 15 (1) (2024)
Fumiaki Ito, Ziyuan Li, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Robert Betsch, John J Krais, Bernadette Taberi, Umeshkumar Vekariya, Marissa L Calbert, Tomasz Skorski, Neil Johnson, Xiaojiang S Chen, Richard T Pomerantz
Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM. Nature communications 15 (1) (2024)
Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S Chen, Reuben Stewart Harris, Michael S Lawrence, Rémi Buisson
Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes. bioRxiv : the preprint server for biology (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Fumiaki Ito, Hanjing Yang, Z Hong Zhou, Xiaojiang S Chen
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15. bioRxiv : the preprint server for biology (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Kyumin Kim, Z Hong Zhou, Xiaojiang S Chen
Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. Nature communications 14 (1) (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Fumiaki Ito, Ana L Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z Hong Zhou, Xiaojiang S Chen
Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. Science advances 9 (1) (2023)
Taylor N Tredinnick, Tatiana Kent, Leonid Minakhin, Ziyuan Li, Jozef Madzo, Xiaojiang S Chen, Richard T Pomerantz
Promoter-Independent Synthesis of Chemically Modified RNA by Polymerase θ Variants. RNA (New York, N.Y.) (2023)
Hanjing Yang, Kyumin Kim, Shuxing Li, Josue Pacheco, Xiaojiang S Chen
Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G. Nature communications 13 (1) (2022)
Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor N Tredinnick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba A Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M Stark, Xiaojiang S Chen, Richard T Pomerantz
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair. Science advances 7 (24) (2021)
Aaron D Wolfe, Shuxing Li, Cody Goedderz, Xiaojiang S Chen
The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity. NAR cancer 2 (4) (2020)
Hanjing Yang, Fumiaki Ito, Aaron D Wolfe, Shuxing Li, Nazanin Mohammadzadeh, Robin P Love, Maocai Yan, Brett Zirkle, Amit Gaba, Linda Chelico, Xiaojiang S Chen
Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Nature communications 11 (1) (2020)
Michael Schlierf, Ganggang Wang, Xiaojiang S Chen, Taekjip Ha
Hexameric helicase G40P unwinds DNA in single base pair steps. eLife 8 (2019)
Dahai Gai, Damian Wang, Shu-Xing Li, Xiaojiang S Chen
Retraction: The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA. eLife 8 (2019)
Dahai Gai, Damian Wang, Shu-Xing Li, Xiaojiang S Chen
The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA. eLife 5 (2016)