Rudi Fasan

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 52

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

Nature chemistry

The Journal of organic chemistry

University of Rochester

University of Zurich (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Rochester

United States

Andrew S. Kende Professor of Chemistry :: Chemistry

University of Rochester

United States

Professor of Chemistry :: Chemistry

University of Rochester Jul 01 2014

United States

Associate Professor of Chemistry :: Department of Chemistry

University of Rochester

United States

Assistant Professor of Chemistry :: Department of Chemistry

California Institute of Technology

United States

Postdoctoral Researcher :: Division of Chemistry and Chemical Engineering

Education History

University of Zurich

Switzerland

PHD :: Institute of Organic Chemistry

University of Padua

Italy

BSC :: Pharmaceutical Chemistry and Sciences

Publications

Satyajit Roy, Yining Wang, Xinyi Zhao, Thakshila Dayananda, Jia-Min Chu, Yong Zhang, Rudi Fasan
Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles. Journal of the American Chemical Society (2024)
David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N Houk, Rudi Fasan
Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nature chemistry (2024)
David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N Houk, Rudi Fasan
Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nature chemistry 16 (5) (2024)
David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N Houk, Rudi Fasan
Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nature chemistry (2024)
Juan D Villada, Jadab Majhi, Valentin Lehuédé, Michelle E Hendricks, Katharina Neufeld, Veronica Tona, Rudi Fasan
Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes. Angewandte Chemie (International ed. in English) (2024)
David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N Houk, Rudi Fasan
Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nature chemistry 16 (5) (2024)
David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N Houk, Rudi Fasan
Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nature chemistry 16 (5) (2024)
Satyajit Roy, Yining Wang, Xinyi Zhao, Thakshila Dayananda, Jia-Min Chu, Yong Zhang, Rudi Fasan
Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles. Journal of the American Chemical Society 146 (29) (2024)
Juan D Villada, Jadab Majhi, Valentin Lehuédé, Michelle E Hendricks, Katharina Neufeld, Veronica Tona, Rudi Fasan
Biocatalytic Strategy for the Highly Stereoselective Synthesis of Fluorinated Cyclopropanes. Angewandte Chemie (International ed. in English) 63 (33) (2024)
David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N Houk, Rudi Fasan
Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nature chemistry 16 (5) (2024)
David A Vargas, Xinkun Ren, Arkajyoti Sengupta, Ledong Zhu, Satyajit Roy, Marc Garcia-Borràs, Kendall N Houk, Rudi Fasan
Biocatalytic strategy for the construction of sp 3 -rich polycyclic compounds from directed evolution and computational modelling. Nature chemistry 16 (5) (2024)
Rudi Fasan, Satyajit Roy, David Vargas, Pengchen Ma, Arkajyoti Sengupta, Kendall N Houk
Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C-H Amidation. Research square (2023)
Donggeon Nam, John-Paul Bacik, Rahul L Khade, Maria Camila Aguilera, Yang Wei, Juan D Villada, Michael L Neidig, Yong Zhang, Nozomi Andob, Rudi Fasan
Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone. Nature communications 14 (1) (2023)
Rudi Fasan, Satyajit Roy, David Vargas, Pengchen Ma, Arkajyoti Sengupta, Kendall N Houk
Stereoselective Construction of β-, γ-, and δ-Lactam Rings via Enzymatic C-H Amidation. Research square (2023)
Jin Gan, Jelle de Vries, Jimmy J L L Akkermans, Yassene Mohammed, Rayman T N Tjokrodirijo, Arnoud H de Ru, Robbert Q Kim, David A Vargas, Vito Pol, Rudi Fasan, Peter A van Veelen, Jacques Neefjes, Hans van Dam, Huib Ovaa, Aysegul Sapmaz, Paul P Geurink
Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2. ACS chemical biology (2023)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society 145 (1) (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society 145 (1) (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society (2022)
Mary G Siriboe, David A Vargas, Rudi Fasan
Dehaloperoxidase Catalyzed Stereoselective Synthesis of Cyclopropanol Esters. The Journal of organic chemistry (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society 145 (1) (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society 145 (1) (2022)
Mary G Siriboe, David A Vargas, Rudi Fasan
Dehaloperoxidase Catalyzed Stereoselective Synthesis of Cyclopropanol Esters. The Journal of organic chemistry (2022)
Donggeon Nam, Antonio Tinoco, Zhuofan Shen, Ronald D Adukure, Gopeekrishnan Sreenilayam, Sagar D Khare, Rudi Fasan
Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N-H Bond Insertion with Acceptor-Acceptor Carbene Donors. Journal of the American Chemical Society 144 (6) (2022)
Xinkun Ren, Ajay L Chandgude, Daniela Maria Carminati, Zhuofan Shen, Sagar D Khare, Rudi Fasan
Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases. Chemical science 13 (29) (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society 145 (1) (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society 145 (1) (2022)
Xinkun Ren, Bo M Couture, Ningyu Liu, Manjinder S Lall, Jeffrey T Kohrt, Rudi Fasan
Enantioselective Single and Dual α-C-H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer. Journal of the American Chemical Society (2022)
Jacob A Iannuzzelli, John-Paul Bacik, Eric J Moore, Zhuofan Shen, Ellen M Irving, David A Vargas, Sagar D Khare, Nozomi Andob, Rudi Fasan
Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization. Biochemistry (2022)
Donggeon Nam, Viktoria Steck, Robert J Potenzino, Rudi Fasan
A Diverse Library of Chiral Cyclopropane Scaffolds via Chemoenzymatic Assembly and Diversification of Cyclopropyl Ketones. Journal of the American Chemical Society 143 (5) (2021)
Daniela Maria Carminati, Jonathan Decaens, Samuel Couve-Bonnaire, Philippe Jubault, Rudi Fasan
Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2 -Containing Trisubstituted Cyclopropanes. Angewandte Chemie (International ed. in English) 60 (13) (2021)
Hanan Alwaseem, Simone Giovani, Michele Crotti, Kevin Welle, Craig T Jordan, Sina Ghaemmaghami, Rudi Fasan
Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS central science 7 (5) (2021)
Jacob A Iannuzzelli, Rudi Fasan
Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells. Chemical science 11 (24) (2020)
Alfons J Pineda-Knauseder, David A Vargas, Rudi Fasan
Organic solvent stability and long-term storage of myoglobin-based carbene transfer biocatalysts. Biotechnology and applied biochemistry 67 (4) (2020)
Xinkun Ren, Ningyu Liu, Ajay L Chandgude, Rudi Fasan
An Enzymatic Platform for the Highly Enantioselective and Stereodivergent Construction of Cyclopropyl-δ-lactones. Angewandte Chemie (International ed. in English) 59 (48) (2020)
Maria Agustina Vila, Viktoria Steck, Sonia Rodriguez Giordano, Ignacio Carrera, Rudi Fasan
C-H Amination via Nitrene Transfer Catalyzed by Mononuclear Non-Heme Iron-Dependent Enzymes. Chembiochem : a European journal of chemical biology 21 (14) (2020)
Xinkun Ren, Ajay L Chandgude, Rudi Fasan
Highly Stereoselective Synthesis of Fused Cyclopropane-γ-Lactams via Biocatalytic Iron-Catalyzed Intramolecular Cyclopropanation. ACS catalysis 10 (3) (2020)
Viktoria Steck, Joshua N Kolev, Xinkun Ren, Rudi Fasan
Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C-H Amination Biocatalysts. Journal of the American Chemical Society 142 (23) (2020)
Ajay L Chandgude, Xinkun Ren, Rudi Fasan
Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases. Journal of the American Chemical Society 141 (23) (2019)
David A Vargas, Rahul L Khade, Yong Zhang, Rudi Fasan
Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds. Angewandte Chemie (International ed. in English) 58 (30) (2019)
Yang Wei, Antonio Tinoco, Viktoria Steck, Rudi Fasan, Yong Zhang
Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution. Journal of the American Chemical Society 140 (5) (2018)
Eric J Moore, Viktoria Steck, Priyanka Bajaj, Rudi Fasan
Chemoselective Cyclopropanation over Carbene Y-H Insertion Catalyzed by an Engineered Carbene Transferase. The Journal of organic chemistry 83 (14) (2018)
Ajay L Chandgude, Rudi Fasan
Highly Diastereo- and Enantioselective Synthesis of Nitrile-Substituted Cyclopropanes by Myoglobin-Mediated Carbene Transfer Catalysis. Angewandte Chemie (International ed. in English) 57 (48) (2018)
David A Vargas, Antonio Tinoco, Vikas Tyagi, Rudi Fasan
Myoglobin-Catalyzed C-H Functionalization of Unprotected Indoles. Angewandte Chemie (International ed. in English) 57 (31) (2018)
Gloria Saab-Rincón, Hanan Alwaseem, Valeria Guzman-Luna, Leticia Olvera, Rudi Fasan
Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 by Consensus-Guided Mutagenesis. Chembiochem : a European journal of chemical biology 19 (6) (2018)
Andrew E Owens, Ivan de Paola, William A Hansen, Yi-Wen Liu, Sagar D Khare, Rudi Fasan
Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. Journal of the American Chemical Society 139 (36) (2017)
Andrew E Owens, Katherine T Grasso, Christine A Ziegler, Rudi Fasan
Two-Tier Screening Platform for Directed Evolution of Aminoacyl-tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency. Chembiochem : a European journal of chemical biology 18 (12) (2017)
Antonio Tinoco, Viktoria Steck, Vikas Tyagi, Rudi Fasan
Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene. Journal of the American Chemical Society 139 (15) (2017)
Eric J Moore, Dmitri Zorine, William A Hansen, Sagar D Khare, Rudi Fasan
Enzyme stabilization via computationally guided protein stapling. Proceedings of the National Academy of Sciences of the United States of America 114 (47) (2017)
Vikas Tyagi, Gopeekrishnan Sreenilayam, Priyanka Bajaj, Antonio Tinoco, Rudi Fasan
Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin-Catalyzed Doyle-Kirmse Reaction. Angewandte Chemie (International ed. in English) 55 (43) (2016)
Vikas Tyagi, Rudi Fasan
Myoglobin-Catalyzed Olefination of Aldehydes. Angewandte Chemie (International ed. in English) 55 (7) (2016)
Priyanka Bajaj, Gopeekrishnan Sreenilayam, Vikas Tyagi, Rudi Fasan
Gram-Scale Synthesis of Chiral Cyclopropane-Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity. Angewandte Chemie (International ed. in English) 55 (52) (2016)

Rudi Fasan.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Rudi Fasan