Huib Ovaa

ResearcherID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 26

Top Venues

Journal of the American Chemical Society

Nature communications

ACS chemical biology

Angewandte Chemie (International ed. in English)

Leiden University Medical Center

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Leiden University Medical Center Jul 01 2016

Netherlands

Principal investigator :: Department of Chemical Immunology

Publications

Bianca D M van Tol, Bjorn R van Doodewaerd, Guinevere S M Lageveen-Kammeijer, Bas C Jansen, Cami M P Talavera Ormeño, Paul J M Hekking, Aysegul Sapmaz, Robbert Q Kim, Angeliki Moutsiopoulou, David Komander, Dana L E Vergoossen, Gerbrand J van der Heden van Noort, Huib Ovaa, Paul P Geurink
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes. Nature communications 14 (1) (2023)
Jin Gan, Jelle de Vries, Jimmy J L L Akkermans, Yassene Mohammed, Rayman T N Tjokrodirijo, Arnoud H de Ru, Robbert Q Kim, David A Vargas, Vito Pol, Rudi Fasan, Peter A van Veelen, Jacques Neefjes, Hans van Dam, Huib Ovaa, Aysegul Sapmaz, Paul P Geurink
Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2. ACS chemical biology (2023)
Bianca D M van Tol, Bjorn R van Doodewaerd, Guinevere S M Lageveen-Kammeijer, Bas C Jansen, Cami M P Talavera Ormeño, Paul J M Hekking, Aysegul Sapmaz, Robbert Q Kim, Angeliki Moutsiopoulou, David Komander, Dana L E Vergoossen, Gerbrand J van der Heden van Noort, Huib Ovaa, Paul P Geurink
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes. Nature communications 14 (1) (2023)
Bianca D M van Tol, Bjorn R van Doodewaerd, Guinevere S M Lageveen-Kammeijer, Bas C Jansen, Cami M P Talavera Ormeño, Paul J M Hekking, Aysegul Sapmaz, Robbert Q Kim, Angeliki Moutsiopoulou, David Komander, Dana L E Vergoossen, Gerbrand J van der Heden van Noort, Huib Ovaa, Paul P Geurink
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes. Nature communications 14 (1) (2023)
Yuqing Jia, Robbert Q Kim, Raymond Kooij, Huib Ovaa, Aysegul Sapmaz, Paul P Geurink
Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput. Journal of medicinal chemistry 65 (19) (2022)
Elma Mons, Robbert Q Kim, Bjorn R van Doodewaerd, Peter A van Veelen, Monique P C Mulder, Huib Ovaa
Exploring the Versatility of the Covalent Thiol-Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease. Journal of the American Chemical Society 143 (17) (2021)
Anastasia Gangaev, Steven L C Ketelaars, Olga I Isaeva, Sanne Patiwael, Anna Dopler, Kelly Hoefakker, Sara De Biasi, Lara Gibellini, Cristina Mussini, Giovanni Guaraldi, Massimo Girardis, Cami M P Talavera Ormeno, Paul J M Hekking, Neubury M Lardy, Mireille Toebes, Robert Balderas, Ton N M Schumacher, Huib Ovaa, Andrea Cossarizza, Pia Kvistborg
Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features. Nature communications 12 (1) (2021)
Daniel Horn-Ghetko, David T Krist, J Rajan Prabu, Kheewoong Baek, Monique P C Mulder, Maren Klügel, Daniel C Scott, Huib Ovaa, Gary Kleiger, Brenda A Schulman
Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature 590 (7847) (2021)
Alexander F Schubert, Justine V Nguyen, Tyler G Franklin, Paul P Geurink, Cameron G Roberts, Daniel J Sanderson, Lauren N Miller, Huib Ovaa, Kay Hofmann, Jonathan N Pruneda, David Komander
Identification and characterization of diverse OTU deubiquitinases in bacteria. The EMBO journal 39 (15) (2020)
Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, Marek Widera, Ahmad Reza Mehdipour, Georg Tascher, Paul P Geurink, Alexander Wilhelm, Gerbrand J van der Heden van Noort, Huib Ovaa, Stefan Müller, Klaus-Peter Knobeloch, Krishnaraj Rajalingam, Brenda A Schulman, Jindrich Cinatl, Gerhard Hummer, Sandra Ciesek, Ivan Đikić
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature 587 (7835) (2020)
Zach W B Armstrong, Chi-Lin Kuo, Daniël Lahav, Bing Liu, Rachel Johnson, Thomas J M Beenakker, Casper de Boer, Chung-Sing Wong, Erwin R van Rijssel, Marjoke F Debets, Bogdan I Florea, Colin Hissink, Rolf G Boot, Paul P Geurink, Huib Ovaa, Mario van der Stelt, Jeroen D C Codée, Jeroen D C Codée, Johannes M F G Aerts, Liang Wu, Herman S Overkleeft, Gideon J Davies
Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. Journal of the American Chemical Society 142 (30) (2020)
Joanna Liwocha, David T Krist, Gerbrand J van der Heden van Noort, Fynn M Hansen, Vinh H Truong, Ozge Karayel, Nicholas Purser, Daniel Houston, Nicole Burton, Mark J Bostock, Michael Sattler, Matthias Mann, Joseph S Harrison, Gary Kleiger, Huib Ovaa, Brenda A Schulman
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler. Nature chemical biology 17 (3) (2020)
Raymond Kooij, Sijia Liu, Aysegul Sapmaz, Bo-Tao Xin, George M C Janssen, Peter A van Veelen, Huib Ovaa, Peter Ten Dijke, Paul P Geurink
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. Journal of the American Chemical Society 142 (39) (2020)
Deepani W Poramba-Liyanage, Tessy Korthout, Christine E Cucinotta, Ila van Kruijsbergen, Tibor van Welsem, Dris El Atmioui, Huib Ovaa, Toshio Tsukiyama, Fred van Leeuwen
Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes. Genome research 30 (4) (2020)
Siddarth Narasimhan, Stephan Scherpe, Alessandra Lucini Paioni, Johan van der Zwan, Gert E Folkers, Huib Ovaa, Marc Baldus
DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells. Angewandte Chemie (International ed. in English) 58 (37) (2019)
Elma Mons, Ineke D C Jansen, Jure Loboda, Bjorn R van Doodewaerd, Jill Hermans, Martijn Verdoes, Constant A A van Boeckel, Peter A van Veelen, Boris Turk, Dusan Turk, Huib Ovaa
The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K. Journal of the American Chemical Society 141 (8) (2019)
Yuqing Jia, Laura A Claessens, Alfred C O Vertegaal, Huib Ovaa
Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs). ACS chemical biology 14 (11) (2019)
Dharjath S Hameed, Aysegul Sapmaz, Lindsey Burggraaff, Alessia Amore, Cornelis J Slingerland, Gerard van Westen, Huib Ovaa
Development of Ubiquitin-Based Probe for Metalloprotease Deubiquitinases. Angewandte Chemie (International ed. in English) 58 (41) (2019)
Lorina Gjonaj, Aysegul Sapmaz, Dennis Flierman, George M C Janssen, Peter A van Veelen, Huib Ovaa
Development of a DUB-selective fluorogenic substrate. Chemical science 10 (44) (2019)
Bo-Tao Xin, Jin Gan, Daniel J Fernandez, Klaus-Peter Knobeloch, Paul P Geurink, Huib Ovaa
Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties. Organic & biomolecular chemistry 17 (48) (2019)
Efrat Resnick, Anthony Bradley, Jinrui Gan, Alice Douangamath, Tobias Krojer, Ritika Sethi, Paul P Geurink, Anthony Aimon, Gabriel Amitai, Dom Bellini, James Bennett, Michael Fairhead, Oleg Fedorov, Ronen Gabizon, Jin Gan, Jingxu Guo, Alexander Plotnikov, Nava Reznik, Gian Filippo Ruda, Laura Díaz-Sáez, Verena M Straub, Tamas Szommer, Srikannathasan Velupillai, Daniel Zaidman, Yanling Zhang, Alun R Coker, Christopher G Dowson, Haim M Barr, Chu Wang, Kilian V M Huber, Paul E Brennan, Huib Ovaa, Frank von Delft, Nir London
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. Journal of the American Chemical Society 141 (22) (2019)
Renier Heijkants, Amina Teunisse, Jelle de Vries, Huib Ovaa, Aart G Jochemsen
Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms. ACS chemical biology 14 (1) (2019)
Dharjath S Hameed, Aysegul Sapmaz, Lorina Gjonaj, Remco Merkx, Huib Ovaa
Enhanced Delivery of Synthetic Labelled Ubiquitin into Live Cells by Using Next-Generation Ub-TAT Conjugates. Chembiochem : a European journal of chemical biology 19 (24) (2018)
Jolien J Luimstra, Malgorzata A Garstka, Marthe C J Roex, Anke Redeker, George M C Janssen, Peter A van Veelen, Ramon Arens, J H Frederik Falkenburg, Jacques J C Neefjes, Huib Ovaa
A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells. The Journal of experimental medicine 215 (5) (2018)
Amy L Palmer, Annemieke de Jong, Yves Leestemaker, Paul P Geurink, Ruud H Wijdeven, Huib Ovaa, Brian P Dolan
Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation. Journal of immunology (Baltimore, Md. : 1950) 200 (3) (2017)
Annemieke de Jong, Katharina Witting, Raymond Kooij, Dennis Flierman, Huib Ovaa
Release of Enzymatically Active Deubiquitinating Enzymes upon Reversible Capture by Disulfide Ubiquitin Reagents. Angewandte Chemie (International ed. in English) 56 (42) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Huib Ovaa