Ryan S Dhindsa (Ryan Dhindsa)

ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 29

Top Venues

Science advances

medRxiv : the preprint server for health sciences

Communications biology

Nature

AstraZeneca UK Ltd

Columbia University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

AstraZeneca UK Ltd Apr 01 2020

United Kingdom

Associate Principle Scientist :: Centre for Genomics Research

Education History

Columbia University May 01 2017 - Mar 31 2020

United States

PHD

Duke University

United States

BSC

Publications

Lawrence Middleton, Ioannis Melas, Chirag Vasavda, Arwa Bin Raies, Benedek Rozemberczki, Ryan S Dhindsa, Justin S Dhindsa, Blake Weido, Quanli Wang, Andrew R Harper, Gavin Edwards, Slavé Petrovski, Dimitrios Michael Vitsios
Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data. Science advances 10 (19) (2024)
Lawrence Middleton, Ioannis Melas, Chirag Vasavda, Arwa Bin Raies, Benedek Rozemberczki, Ryan S Dhindsa, Justin S Dhindsa, Blake Weido, Quanli Wang, Andrew R Harper, Gavin Edwards, Slavé Petrovski, Dimitrios Michael Vitsios
Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data. Science advances 10 (19) (2024)
Jonathan Mitchell, Niedzica Camacho, Patrick Shea, Konrad H Stopsack, Vijai Joseph, Oliver S Burren, Ryan S Dhindsa, Abhishek Nag, Jacob E Berchuck, Amanda O'Neill, Ali Abbasi, Anthony W Zoghbi, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen-Campos, Roberto Tapia-Conyer, Jonathan Emberson, Jason M Torres, Rory Collins, Quanli Wang, David Goldstein, Athena Matakidou, Carolina Haefliger, Lauren Anderson-Dring, Ruth March, Vaidehi Jobanputra, Brian Dougherty, Keren Carss, Slavé Petrovski, Philip W Kantoff, Kenneth Offit, Lorelei A Mucci, Mark Pomerantz, Margarete A Fabre
Characterising the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases. medRxiv : the preprint server for health sciences (2024)
Oliver S Burren, Ryan S Dhindsa, Sri V V Deevi, Sean Wen, Abhishek Nag, Jonathan Mitchell, Fengyuan Hu, Douglas P Loesch, Katherine R Smith, Neetu Razdan, Henric Olsson, Adam Platt, Dimitrios Michael Vitsios, Qiang Wu, null null, Veryan Codd, Christopher P Nelson, Nilesh J Samani, Ruth E March, Sebastian Wasilewski, Keren Jacqueline Carss, Margarete Fabre, Quanli Wang, Menelas N Pangalos, Slavé Petrovski
Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences. Nature genetics (2024)
Manik Garg, Marcin Karpinski, Dorota Matelska, Lawrence Middleton, Oliver S Burren, Fengyuan Hu, Eleanor Wheeler, Katherine R Smith, Margarete A Fabre, Jonathan Mitchell, Amanda O'Neill, Euan A Ashley, Andrew R Harper, Quanli Wang, Ryan S Dhindsa, Slavé Petrovski, Dimitrios Michael Vitsios
Disease prediction with multi-omics and biomarkers empowers case-control genetic discoveries in the UK Biobank. Nature genetics 56 (9) (2024)
Jonathan Mitchell, Niedzica Camacho, Patrick Shea, Konrad H Stopsack, Vijai Joseph, Oliver S Burren, Ryan S Dhindsa, Abhishek Nag, Jacob E Berchuck, Amanda O'Neill, Ali Abbasi, Anthony W Zoghbi, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen-Campos, Roberto Tapia-Conyer, Jonathan Emberson, Jason M Torres, Rory Collins, Quanli Wang, David Goldstein, Athena Matakidou, Carolina Haefliger, Lauren Anderson-Dring, Ruth March, Vaidehi Jobanputra, Brian Dougherty, Keren Carss, Slavé Petrovski, Philip W Kantoff, Kenneth Offit, Lorelei A Mucci, Mark Pomerantz, Margarete A Fabre
Characterising the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases. medRxiv : the preprint server for health sciences (2024)
Lawrence Middleton, Ioannis Melas, Chirag Vasavda, Arwa Bin Raies, Benedek Rozemberczki, Ryan S Dhindsa, Justin S Dhindsa, Blake Weido, Quanli Wang, Andrew R Harper, Gavin Edwards, Slavé Petrovski, Dimitrios Michael Vitsios
Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data. Science advances 10 (19) (2024)
Jonathan Mitchell, Niedzica Camacho, Patrick Shea, Konrad H Stopsack, Vijai Joseph, Oliver S Burren, Ryan S Dhindsa, Abhishek Nag, Jacob E Berchuck, Amanda O'Neill, Ali Abbasi, Anthony W Zoghbi, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen-Campos, Roberto Tapia-Conyer, Jonathan Emberson, Jason M Torres, Rory Collins, Quanli Wang, David Goldstein, Athena Matakidou, Carolina Haefliger, Lauren Anderson-Dring, Ruth March, Vaidehi Jobanputra, Brian Dougherty, Keren Carss, Slavé Petrovski, Philip W Kantoff, Kenneth Offit, Lorelei A Mucci, Mark Pomerantz, Margarete A Fabre
Characterising the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases. medRxiv : the preprint server for health sciences (2024)
Esmeralda Villavicencio Gonzalez, Ryan S Dhindsa
Studying ultra-rare variants in STX1A uncovers a novel neurodevelopmental disorder. European journal of human genetics : EJHG (2023)
Ryan S Dhindsa, Oliver S Burren, Benjamin B Sun, Bram P Prins, Dorota Matelska, Eleanor Wheeler, Jonathan Mitchell, Andreas Bender, Ventzislava A Hristova, Katherine R Smith, Keren Jacqueline Carss, Sebastian Wasilewski, Andrew R Harper, Dirk S Paul, Margarete A Fabre, Heiko Runz, Coralie Viollet, Benjamin Challis, Adam Platt, null null, Dimitrios Michael Vitsios, Euan A Ashley, Christopher D Whelan, Menelas N Pangalos, Quanli Wang, Slavé Petrovski
Rare variant associations with plasma protein levels in the UK Biobank. Nature (2023)
Arwa Bin Raies, Ewa Tulodziecka, James Stainer, Lawrence Middleton, Ryan S Dhindsa, Pamela Hill, Ola Engkvist, Andrew R Harper, Slavé Petrovski, Dimitrios Michael Vitsios
Author Correction: DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets. Communications biology 6 (1) (2023)
Sih-Rong Wu, Jessica C Butts, Matthew S Caudill, Jean-Pierre Revelli, Ryan S Dhindsa, Mark A Durham, Huda Yaya Zoghbi
Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation. Science advances 9 (26) (2023)
Sarah A Dugger, Ryan S Dhindsa, Gabriela De Almeida Sampaio, Andrew K Ressler, Elizabeth E Rafikian, Sabrina Petri, Verity A Letts, JiaJie Teoh, Junqiang Ye, Sophie Colombo, Yueqing Peng, Mu Yang, Michael J Boland, Wayne N Frankel, David B Goldstein
Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency. PLoS genetics 19 (10) (2023)
Sih-Rong Wu, Jessica C Butts, Matthew S Caudill, Jean-Pierre Revelli, Ryan S Dhindsa, Mark A Durham, Huda Yaya Zoghbi
Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation. Science advances 9 (26) (2023)
Sih-Rong Wu, Jessica C Butts, Matthew S Caudill, Jean-Pierre Revelli, Ryan S Dhindsa, Mark A Durham, Huda Yaya Zoghbi
Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation. Science advances 9 (26) (2023)
Dimitrios Michael Vitsios, Ryan S Dhindsa, Dorota Matelska, Jonathan Mitchell, Xuequing Zou, Joshua Armenia, Fengyuan Hu, Quanli Wang, Ben S Sidders, Andrew R Harper, Slavé Petrovski
Cancer-driving mutations are enriched in genic regions intolerant to germline variation. Science advances 8 (34) (2022)
Chirag Vasavda, Risheng Xu, Jason Liew, Ruchita Kothari, Ryan S Dhindsa, Evan R Semenza, Bindu D Paul, Dustin P Green, Mark F Sabbagh, Joseph Yusup Shin, Wuyang Yang, Adele M Snowman, Lauren K Albacarys, Abhay R Moghekar, Carlos A Pardo-Villamizar, Mark Luciano, Judy Huang, Chetan Bettegowda, Shawn G Kwatra, Xinzhong Dong, Michael Lim, Solomon H Snyder
Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Science advances 8 (31) (2022)
Tristan J Hayeck, Nicholas Stong, Evan Baugh, Ryan S Dhindsa, Tychele N Turner, Ayan Malakar, Timothy L Mosbruger, Grace Tzun-Wen Shaw, Yuncheng Duan, Iuliana Ionita-Laza, David Goldstein, Andrew S Allen
Ancestry adjustment improves genome-wide estimates of regional intolerance. Genetics 221 (2) (2022)
Abhishek Nag, Ryan S Dhindsa, Jonathan Mitchell, Chirag Vasavda, Andrew R Harper, Dimitrios Michael Vitsios, Andrea Ahnmark, Bilada Bilican, Katja Madeyski-Bengtson, Bader Zarrouki, Anthony W Zoghbi, Quanli Wang, Katherine R Smith, Jesus Alegre, Pablo Kuri-Morales, Jaime Berumen-Campos, Roberto Tapia-Conyer, Jonathan R Emberson, Jason M Torres, Rory Collins, David M Smith, Benjamin G Challis, Dirk S Paul, Mohammad Bohlooly-Y, Mike Snowden, David Baker, Regina Fritsche Danielson, Menelas N Pangalos, Slavé Petrovski
Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes. Science advances 8 (46) (2022)
Mahmoud E Koko, Joshua E Motelow, Kate E Stanley, Dheeraj Reddy Bobbili, Ryan S Dhindsa, Patrick May, null null, null null, null null, null null, null null
Association of ultra-rare coding variants with genetic generalized epilepsy: A case-control whole exome sequencing study. Epilepsia 63 (3) (2022)
Chirag Vasavda, Evan R Semenza, Jason Liew, Ruchita Kothari, Ryan S Dhindsa, Shruthi Shanmukha, Anthony Lin, Robert Tokhunts, Cristina Ricco, Adele M Snowman, Lauren Albacarys, Francesco Pastore, Cristian Ripoli, Claudio Grassi, Eugenio Barone, Michael D Kornberg, Xinzhong Dong, Bindu D Paul, Solomon H Snyder
Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling. Science signaling 15 (733) (2022)
Arwa Bin Raies, Ewa Tulodziecka, James Stainer, Lawrence Middleton, Ryan S Dhindsa, Pamela Hill, Ola Engkvist, Andrew R Harper, Slavé Petrovski, Dimitrios Michael Vitsios
DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets. Communications biology 5 (1) (2022)
Anthony W Zoghbi, Ryan S Dhindsa, Terry E Goldberg, Aydan Mehralizade, Joshua E Motelow, Xinchen Wang, Anna Alkelai, Matthew B Harms, Jeffrey A Lieberman, Sander Markx, David B Goldstein
High-impact rare genetic variants in severe schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 118 (51) (2022)
Ryan S Dhindsa, Johan Mattsson, Abhishek Nag, Quanli Wang, Louise V Wain, Richard J Allen, Eleanor M Wigmore, Kristina Ibanez, Dimitrios Vitsios, Sri V V Deevi, Sebastian Wasilewski, Maria Karlsson, Glenda Lassi, Henric Olsson, Daniel Muthas, Susan Monkley, Alex Mackay, Lynne Murray, Simon Young, Carolina Haefliger, null null, Toby M Maher, Maria G Belvisi, R Gisli Jenkins, Philip L Molyneaux, Adam Platt, Slavé Petrovski
Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis. Communications biology 4 (1) (2021)
Dimitrios Vitsios, Ryan S Dhindsa, Lawrence Middleton, Ayal B Gussow, Slavé Petrovski
Prioritizing non-coding regions based on human genomic constraint and sequence context with deep learning. Nature communications 12 (1) (2021)
Quanli Wang, Ryan S Dhindsa, Keren Carss, Andrew R Harper, Abhishek Nag, Ioanna Tachmazidou, Dimitrios Vitsios, Sri V V Deevi, Alex Mackay, Daniel Muthas, Michael Hühn, Susan Monkley, Henric Olsson, null null, Sebastian Wasilewski, Katherine R Smith, Ruth March, Adam Platt, Carolina Haefliger, Slavé Petrovski
Rare variant contribution to human disease in 281,104 UK Biobank exomes. Nature 597 (7877) (2021)
Ryan S Dhindsa, Anthony W Zoghbi, Daniel K Krizay, Chirag Vasavda, David B Goldstein
A Transcriptome-Based Drug Discovery Paradigm for Neurodevelopmental Disorders. Annals of neurology 89 (2) (2020)
Sahar Gelfman, Quanli Wang, Yi-Fan Lu, Diana Hall, Christopher D Bostick, Ryan S Dhindsa, Matthew W Halvorsen, K Melodi McSweeney, Ellese Cotterill, Tom Edinburgh, Michael A Beaumont, Wayne N Frankel, Slavé Petrovski, Andrew S Allen, Michael J Boland, David B Goldstein, Stephen J Eglen
meaRtools: An R package for the analysis of neuronal networks recorded on microelectrode arrays. PLoS computational biology 14 (10) (2018)
Ayal B Gussow, Brett R Copeland, Ryan S Dhindsa, Quanli Wang, Slavé Petrovski, William H Majoros, Andrew S Allen, David B Goldstein
Orion: Detecting regions of the human non-coding genome that are intolerant to variation using population genetics. PloS one 12 (8) (2017)
Xiaolin Zhu, Slavé Petrovski, Pingxing Xie, Elizabeth K Ruzzo, Yi-Fan Lu, K Melodi McSweeney, Bruria Ben-Zeev, Andreea Nissenkorn, Yair Anikster, Danit Oz-Levi, Ryan S Dhindsa, Yuki Hitomi, Kelly Schoch, Rebecca C Spillmann, Gali Heimer, Dina Marek-Yagel, Michal Tzadok, Yujun Han, Gordon Worley, Jennifer Goldstein, Yong-Hui Jiang, Doron Lancet, Elon Pras, Vandana Shashi, Duncan McHale, Anna C Need, David B Goldstein
Whole-exome sequencing in undiagnosed genetic diseases: interpreting 119 trios. Genetics in medicine : official journal of the American College of Medical Genetics 17 (10) (2015)

Ryan S Dhindsa.css-eqlu8i{font-size:small;padding-left:4px;} (Ryan Dhindsa)

Publication Activity (10 Years)

Top Topics

Top Venues

Ryan S Dhindsa (Ryan Dhindsa)