Huda Yaya Zoghbi (Huda Y Zoghbi)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 43

Top Venues

eLife

The Journal of neuroscience : the official journal of the Society for Neuroscience

Science advances

eNeuro

Texas Children's Hospital

American University of Beirut (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Texas Children's Hospital Dec 01 2010

United States

Director :: Jan and Dan Duncan Neurological Research Institute

Howard Hughes Medical Institute Sep 01 1994

United States

Investigator :: Molecular and Human Genetics

Baylor College of Medicine Jun 01 1994

United States

Professor :: Departments of Pediatrics, Molecular and Human Genetics, Neurology, and Neuroscience

Baylor College of Medicine Jun 01 1991 - May 30 1994

United States

Associate Professor :: Departments of Pediatricsand Molecular and Human Genetics, and Division of Neuroscience

Baylor College of Medicine Jun 01 1988 - May 30 1991

United States

Assistant Professor :: Pediatrics, Section of Neurology; and Institute for Molecular Genetics

Baylor College of Medicine Jun 01 1985 - May 30 1988

United States

Research Assistant Professor :: Pediatrics

Education History

American University of Beirut

Lebanon

BSC

Publications

Dah-Eun Chloe Chung, Xue Deng, Hari Krishna Yalamanchili, Jean-Pierre Revelli, Alexander L Han, Bakhos Tadros, Ronald Richman, Michelle Dias, Fatemeh Alavi Naini, Steven Boeynaems, Bradley T Hyman, Huda Yaya Zoghbi
The big tau splice isoform resists Alzheimer's-related pathological changes. bioRxiv : the preprint server for biology (2024)
Sameer S Bajikar, Yehezkel Sztainberg, Alexander J Trostle, Harini P Tirumala, Ying-Wooi Wan, Caroline L Harrop, Jesse D Bengtsson, Cláudia M B Carvalho, Davut Pehlivan, Bernhard Suter, Jeffrey L Neul, Zhandong Liu, Paymaan Jafar-Nejad, Frank Rigo, Huda Yaya Zoghbi
Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels. Human molecular genetics (2024)
Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Yaya Zoghbi
MeCP2 regulates Gdf11 , a dosage-sensitive gene critical for neurological function. eLife 12 (2023)
Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Yaya Zoghbi
MeCP2 regulates Gdf11 , a dosage-sensitive gene critical for neurological function. eLife 12 (2023)
Sih-Rong Wu, Jessica C Butts, Matthew S Caudill, Jean-Pierre Revelli, Ryan S Dhindsa, Mark A Durham, Huda Yaya Zoghbi
Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation. Science advances 9 (26) (2023)
Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Yaya Zoghbi
MeCP2 regulates Gdf11 , a dosage-sensitive gene critical for neurological function. eLife 12 (2023)
Sih-Rong Wu, Huda Yaya Zoghbi
The Atoh1-Cre Knock-In Allele Ectopically Labels a Subpopulation of Amacrine Cells and Bipolar Cells in Mouse Retina. eNeuro 10 (11) (2023)
Sih-Rong Wu, Jessica C Butts, Matthew S Caudill, Jean-Pierre Revelli, Ryan S Dhindsa, Mark A Durham, Huda Yaya Zoghbi
Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation. Science advances 9 (26) (2023)
Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P Tirumala, Carlo Vetralla, Sameer S Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J Ferrie, Anel LaGrone, Ping Zhang, Jean J Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tse Nan Tjian, Huda Yaya Zoghbi
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Genes & development (2023)
Sih-Rong Wu, Jessica C Butts, Matthew S Caudill, Jean-Pierre Revelli, Ryan S Dhindsa, Mark A Durham, Huda Yaya Zoghbi
Atoh1 drives the heterogeneity of the pontine nuclei neurons and promotes their differentiation. Science advances 9 (26) (2023)
Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Yaya Zoghbi
MeCP2 regulates Gdf11 , a dosage-sensitive gene critical for neurological function. eLife 12 (2023)
Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Yaya Zoghbi
MeCP2 regulates Gdf11 , a dosage-sensitive gene critical for neurological function. eLife 12 (2023)
Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Yaya Zoghbi
MeCP2 regulates Gdf11 , a dosage-sensitive gene critical for neurological function. eLife 12 (2023)
Nathan P Achilly, Wei Wang, Huda Yaya Zoghbi
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome. Nature 592 (7855) (2021)
Meike E Van der Heijden, Elizabeth P Lackey, Ross Perez, Fatma S Ișleyen, Amanda M Brown, Sarah G Donofrio, Tao Lin, Huda Yaya Zoghbi, Roy V Sillitoe
Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons. eLife 10 (2021)
Ryan Thomas Ash, Jiyoung Park, Bernhard Suter, Huda Yaya Zoghbi, Stelios Manolis Smirnakis
Excessive Formation and Stabilization of Dendritic Spine Clusters in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro 8 (1) (2021)
Won-Seok Lee, Laura Lavery, Maxime W C Rousseaux, Eric B Rutledge, Youjin Jang, Ying-Wooi Wan, Sih-Rong Wu, Wonho Kim, Ismael Al-Ramahi, Smruti Rath, Carolyn J Adamski, Vitaliy V Bondar, Ambika Tewari, Shirin Soleimani, Samantha Mota, Hari K Yalamanchili, Harry T Orr, Zhandong Liu, Juan Botas, Huda Yaya Zoghbi
Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1. The EMBO journal 40 (7) (2021)
Yingyao Shao, Yehezkel Sztainberg, Qi Wang, Sameer S Bajikar, Alexander J Trostle, Ying-Wooi Wan, Paymaan Jafar-Nejad, Frank Rigo, Zhandong Liu, Jianrong Tang, Huda Yaya Zoghbi
Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome. Science translational medicine 13 (583) (2021)
Nathan P Achilly, Ling-Jie He, Olivia A Kim, Shogo Ohmae, Gregory J Wojaczynski, Tao Lin, Roy V Sillitoe, Javier F Medina, Huda Yaya Zoghbi
Deleting Mecp2 from the cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice. eLife 10 (2021)
Aya Ito-Ishida, Steven A Baker, Roy V Sillitoe, Yaling Sun, Jian Zhou, Yukiteru Ono, Junichi Iwakiri, Michisuke Yuzaki, Huda Yaya Zoghbi
MeCP2 Levels Regulate the 3D Structure of Heterochromatic Foci in Mouse Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 40 (45) (2020)
Laura A Lavery, Kerstin Ure, Ying-Wooi Wan, Chongyuan Luo, Alexander J Trostle, Wei Wang, Haijing Jin, Joanna Lopez, Jacinta Lucero, Mark A Durham, Rosa Castanon, Joseph R Nery, Zhandong Liu, Margaret A Goodell, Joseph R Ecker, M Margarita Behrens, Huda Yaya Zoghbi
Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome. eLife 9 (2020)
Callison E Alcott, Hari Krishna Yalamanchili, Ping Ji, Meike E Van der Heijden, Alexander B Saltzman, Nathan D Elrod, Ai Lin, Mei Leng, Bhoomi Bhatt, Shuang Hao, Qi Wang, Afaf Saliba, Jianrong Tang, Anna Malovannaya, Eric J Wagner, Zhandong Liu, Huda Yaya Zoghbi
Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation. eLife 9 (2020)
Wu Chen, Zhao-Lin Cai, Eugene S Chao, Hongmei Chen, Colleen M Longley, Shuang Hao, Hsiao-Tuan Chao, Joo Hyun Kim, Jessica E Messier, Huda Yaya Zoghbi, Jianrong Tang, John W Swann, Mingshan Xue
Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. eLife 9 (2020)
Xiangling Meng, Christopher M McGraw, Wei Wang, Junzhan Jing, Szu-Ying Yeh, Li Wang, Joanna Lopez, Amanda M Brown, Tao Lin, Wu Chen, Mingshan Xue, Roy V Sillitoe, Xiaolong Jiang, Huda Yaya Zoghbi
Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions. eLife 8 (2019)
Meike E Van der Heijden, Huda Yaya Zoghbi
Development of the brainstem respiratory circuit. Wiley interdisciplinary reviews. Developmental biology 9 (3) (2019)
Gabriel E Vázquez-Vélez, Kristyn A Gonzales, Jean-Pierre Revelli, Carolyn J Adamski, Fatemeh Alavi Naini, Aleksandar Bajic, Evelyn Craigen, Ronald Richman, Sabrina M Heman-Ackah, Matthew J A Wood, Maxime W C Rousseaux, Huda Yaya Zoghbi
Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience 40 (2) (2019)
Li Wang, Carolyn J Adamski, Vitaliy V Bondar, Evelyn Craigen, John R Collette, Kaifang Pang, Kihoon Han, Antrix Jain, Sung Y Jung, Zhandong Liu, Richard N Sifers, J Lloyd Holder, Huda Yaya Zoghbi
A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability. Molecular psychiatry 25 (10) (2019)
Elizabeth C Ballinger, Christian P Schaaf, Akash J Patel, Antonia de Maio, Huifang Tao, David A Talmage, Huda Yaya Zoghbi, Lorna W Role
Mecp2 Deletion from Cholinergic Neurons Selectively Impairs Recognition Memory and Disrupts Cholinergic Modulation of the Perirhinal Cortex. eNeuro 6 (6) (2019)
Li Wang, Kaifang Pang, Kihoon Han, Carolyn J Adamski, Wei Wang, Lingjie He, Jason K Lai, Vitaliy V Bondar, Joseph G Duman, Ronald Richman, Kimberley F Tolias, Patrick Barth, Timothy Palzkill, Zhandong Liu, J Lloyd Holder, Huda Yaya Zoghbi
An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function. Molecular psychiatry 25 (10) (2019)
Sara E Kee, Xiang Mou, Huda Yaya Zoghbi, Daoyun Ji
Impaired spatial memory codes in a mouse model of Rett syndrome. eLife 7 (2018)
Maxime W C Rousseaux, Jean-Pierre Revelli, Gabriel E Vázquez-Vélez, Ji-Yoen Kim, Evelyn Craigen, Kristyn Gonzales, Jaclyn Beckinghausen, Huda Yaya Zoghbi
Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau. eLife 7 (2018)
Amy E Pohodich, Hari Yalamanchili, Ayush T Raman, Ying-Wooi Wan, Michael Gundry, Shuang Hao, Haijing Jin, Jianrong Tang, Zhandong Liu, Huda Yaya Zoghbi
Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity. eLife 7 (2018)
Ayush T Raman, Amy E Pohodich, Ying-Wooi Wan, Hari Krishna Yalamanchili, William E Lowry, Huda Yaya Zoghbi, Zhandong Liu
Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations. Nature communications 9 (1) (2018)
Maxime W C Rousseaux, Gabriel E Vázquez-Vélez, Ismael Al-Ramahi, Hyun-Hwan Jeong, Aleksandar Bajić, Jean-Pierre Revelli, Hui Ye, Emily T Phan, Jennifer M Deger, Alma M Perez, Ji-Yoen Kim, Laura A Lavery, Qikia Xu, Mamie Z Li, Hyojin Kang, Jean J Kim, Joshua M Shulman, Thomas F Westbrook, Stephen J Elledge, Zhandong Liu, Juan Botas, Huda Yaya Zoghbi
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach. The Journal of neuroscience : the official journal of the Society for Neuroscience 38 (43) (2018)
Meike E Van der Heijden, Huda Yaya Zoghbi
Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. eLife 7 (2018)
James P Orengo, Meike E van der Heijden, Shuang Hao, Jianrong Tang, Harry T Orr, Huda Yaya Zoghbi
Motor neuron degeneration correlates with respiratory dysfunction in SCA1. Disease models & mechanisms 11 (2) (2018)
Aya Ito-Ishida, Hari Krishna Yamalanchili, Yingyao Shao, Steven A Baker, Laura D Heckman, Laura A Lavery, Ji-Yoen Kim, Laura M Lombardi, Yaling Sun, Zhandong Liu, Huda Yaya Zoghbi
Genome-wide distribution of linker histone H1.0 is independent of MeCP2. Nature neuroscience 21 (6) (2018)
Laura M Lombardi, Manar Zaghlula, Yehezkel Sztainberg, Steven Andrew Baker, Tiemo J Klisch, Amy A Tang, Eric J Huang, Huda Yaya Zoghbi
An RNA interference screen identifies druggable regulators of MeCP2 stability. Science translational medicine 9 (404) (2018)
Tiemo J Klisch, Anna Vainshtein, Akash J Patel, Huda Yaya Zoghbi
Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth. eLife 6 (2017)
Wei Rose Xie, Hsin-I Jen, Michelle L Seymour, Szu-Ying Yeh, Fredrick A Pereira, Andrew K Groves, Tiemo J Klisch, Huda Yaya Zoghbi
An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (36) (2017)
Xiangling Meng, Wei Wang, Hui Lu, Ling-Jie He, Wu Chen, Eugene S Chao, Marta L Fiorotto, Bin Tang, Jose A Herrera, Michelle L Seymour, Jeffrey L Neul, Fred A Pereira, Jianrong Tang, Mingshan Xue, Huda Yaya Zoghbi
Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders. eLife 5 (2016)
Maxime Wc Rousseaux, Maria de Haro, Cristian A Lasagna-Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar-Nejad, Ismael Al-Ramahi, Ajay Sharma, Lauren See, Nan Lu, Luis Vilanova-Velez, Tiemo J Klisch, Thomas F Westbrook, Juan C Troncoso, Juan Botas, Huda Yaya Zoghbi
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. eLife 5 (2016)
Kerstin Ure, Hui Lu, Wei Wang, Aya Ito-Ishida, Zhenyu Wu, Ling-Jie He, Yehezkel Sztainberg, Wu Chen, Jianrong Tang, Huda Yaya Zoghbi
Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome. eLife 5 (2016)

Huda Yaya Zoghbi.css-eqlu8i{font-size:small;padding-left:4px;} (Huda Y Zoghbi)

Publication Activity (10 Years)

Top Topics

Top Venues

Huda Yaya Zoghbi (Huda Y Zoghbi)