Shahram Misaghi

ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 16

Top Venues

Biotechnology progress

Biotechnology journal

Biotechnology and bioengineering

Genentech Inc

Harvard University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Genentech Inc

United States

Senior Scientist :: Early Stage Cell Culture

Education History

Harvard University

United States

PHD :: Biological Chemistry and Molecular Pharmacology

Publications

Cynthia Lam, Joseph Carver, Domingos Ng, Dejin Zhan, Danming Tang, Thara Kandamkalam, Brad Snedecor, Gavin Barnard, Amy Shen, Shahram Misaghi
Combining regulated and constitutive protein expression significantly boosts protein expression by increasing productivity without affecting CHO cell growth. Biotechnology progress (2023)
Cynthia Lam, Joseph Carver, Domingos Ng, Dejin Zhan, Danming Tang, Thara Kandamkalam, Brad Snedecor, Gavin Barnard, Amy Shen, Shahram Misaghi
Combining Regulated and Constitutive Protein Expression Significantly Boosts Protein Expression by Increasing Productivity without Affecting CHO Cell Growth. Biotechnology progress (2023)
Brian M Castellano, Danming Tang, Scot Marsters, Cynthia Lam, Peter Liu, Christopher M Rose, Wendy Sandoval, Avi Ashkenazi, Brad Snedecor, Shahram Misaghi
Activation of the PERK branch of the unfolded protein response during production reduces specific productivity in CHO cells via downregulation of PDGFRa and IRE1a signaling. Biotechnology progress (2023)
Danming Tang, Jane Gunson, Eric Tran, Cynthia Lam, Amy Shen, Brad Snedecor, Gavin Barnard, Shahram Misaghi
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study. Biotechnology progress 38 (6) (2022)
Danming Tang, Jane Gunson, Eric Tran, Cynthia Lam, Amy Shen, Brad Snedecor, Gavin Barnard, Shahram Misaghi
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study. Biotechnology progress 38 (6) (2022)
Danming Tang, Jane Gunson, Eric Tran, Cynthia Lam, Amy Shen, Brad Snedecor, Gavin Barnard, Shahram Misaghi
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study. Biotechnology progress 38 (6) (2022)
Danming Tang, Jane Gunson, Eric Tran, Cynthia Lam, Amy Shen, Brad Snedecor, Gavin Barnard, Shahram Misaghi
Expressing antigen binding fragments with high titers in a targeted integration CHO host by optimizing expression vector gene copy numbers and position: A case study. Biotechnology progress 38 (6) (2022)
Danming Tang, Cynthia Lam, Niels Bauer, Simon Auslaender, Brad Snedecor, Michael W Laird, Shahram Misaghi
Bax and Bak knockout apoptosis-resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed-batch culture process. Biotechnology progress 38 (2) (2022)
Danming Tang, Wendy Sandoval, Peter Liu, Cynthia Lam, Brad Snedecor, Shahram Misaghi
Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle. Biotechnology progress 37 (5) (2021)
Noelia Blanco, Ambrose J Williams, Danming Tang, Dejin Zhan, Shahram Misaghi, Robert F Kelley, Laura C Simmons
Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product-related impurities in CHO cells. Biotechnology and bioengineering 117 (7) (2020)
Salina Louie, Amy Heidersbach, Noelia Blanco, Benjamin Haley, Christopher M Rose, Peter S Liu, Mandy Yim, Danming Tang, Cynthia Lam, Wendy N Sandoval, David Shaw, Brad Snedecor, Shahram Misaghi
Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum-free media. Biotechnology progress 36 (3) (2020)
Emily Dong, Cynthia Lam, Danming Tang, Salina Louie, Mandy Yim, Ambrose J Williams, William Sawyer, Shirley Yip, Joseph Carver, Ali AlBarakat, Joni Tsukuda, Brad Snedecor, Shahram Misaghi
Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost-effective method for expression of complex molecules. Biotechnology journal 16 (4) (2020)
Tomofumi Tadauchi, Cynthia Lam, Laura Liu, Yizhou Zhou, Danming Tang, Salina Louie, Brad Snedecor, Shahram Misaghi
Utilizing a regulated targeted integration cell line development approach to systematically investigate what makes an antibody difficult to express. Biotechnology progress 35 (2) (2019)
Danming Tang, Cynthia Lam, Salina Louie, Kam Hon Hoi, David Shaw, Mandy Yim, Brad Snedecor, Shahram Misaghi
Supplementation of Nucleosides During Selection can Reduce Sequence Variant Levels in CHO Cells Using GS/MSX Selection System. Biotechnology journal 13 (1) (2017)
Peggy Ko, Shahram Misaghi, Zhilan Hu, Dejin Zhan, Joni Tsukuda, Mandy Yim, Mark Sanford, David Shaw, Masaru Shiratori, Brad Snedecor, Michael Laird, Amy Shen
Probing the importance of clonality: Single cell subcloning of clonally derived CHO cell lines yields widely diverse clones differing in growth, productivity, and product quality. Biotechnology progress 34 (3) (2017)
Yizhou Zhou, David Shaw, Cynthia Lam, Joni Tsukuda, Mandy Yim, Danming Tang, Salina Louie, Michael W Laird, Brad Snedecor, Shahram Misaghi
Beating the odds: The poisson distribution of all input cells during limiting dilution grossly underestimates whether a cell line is clonally-derived or not. Biotechnology progress 34 (3) (2017)

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Publication Activity (10 Years)

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Shahram Misaghi