Stefan N Constantinescu (Stefan Constantinescu)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 25

Top Venues

Blood

American journal of hematology

Leukemia

Oncogene

Université Catholique de Louvain

Université Catholique de Louvain (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Université Catholique de Louvain

Belgium

Professor of Cell Biology, Molecular Biology and Physiology :: Science Sector and Faculty of Medicine

Ludwig Institute for Cancer Research Brussels Branch of Human Cancer Cell Genetics

Belgium

Member :: Signaling, Tumor Biology

Christian de Duve Institute of Cellular Pathology

Belgium

Member :: Cell Signaling

Christian de Duve Institute of Cellular Pathology

Belgium

Group Leader :: Cell Signaling

Education History

Université Catholique de Louvain

Belgium

PHD

Universitatea de Medicin? ?i Farmacie Carol Davila Facultatea de Medicin?

Romania

PHD

Publications

Jihyun Song, Lucie Lanikova, Soo Jin Kim, Nicolas Papadopoulos, Jessica A Meznarich, Stefan N Constantinescu, Brynn Parsegov, Jaroslav F Prchal, Josef T Prchal
Novel germline JAK2 R715T mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon. American journal of hematology (2024)
Jihyun Song, Lucie Lanikova, Soo Jin Kim, Nicolas Papadopoulos, Jessica A Meznarich, Stefan N Constantinescu, Brynn Parsegov, Jaroslav F Prchal, Josef T Prchal
Novel germline JAK2 R715T mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon. American journal of hematology 99 (7) (2024)
Stefan N Constantinescu, William Vainchenker
DNMT3A gates IFN-induced MPN HSC exhaustion. Blood 143 (24) (2024)
Jihyun Song, Lucie Lanikova, Soo Jin Kim, Nicolas Papadopoulos, Jessica A Meznarich, Stefan N Constantinescu, Brynn Parsegov, Jaroslav F Prchal, Josef T Prchal
Novel germline JAK2 R715T mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon. American journal of hematology 99 (7) (2024)
Stefan N Constantinescu, William Vainchenker
DNMT3A gates IFN-induced MPN HSC exhaustion. Blood 143 (24) (2024)
Jihyun Song, Lucie Lanikova, Soo Jin Kim, Nicolas Papadopoulos, Jessica A Meznarich, Stefan N Constantinescu, Brynn Parsegov, Jaroslav F Prchal, Josef T Prchal
Novel germline JAK2 R715T mutation causing PV-like erythrocytosis in 3 generations. Amelioration by Ropeg-Interferon. American journal of hematology 99 (7) (2024)
Christophe Willekens, Lucie Laplane, Tracy Dagher, Camelia Benlabiod, Nicolas Papadopoulos, Catherine Lacout, Philippe Rameau, Cyril Catelain, Alexia Alfaro, Valérie Edmond, Nicolas Signolle, Valentine Marchand, Nathalie M Droin, Remco Hoogenboezem, Rebekka K Schneider, Alex Penson, Omar Abdel-Wahab, Stephane Giraudier, Florence Pasquier, Caroline Marty, Isabelle Plo, Jean-Luc J-L Villeval, Stefan N Constantinescu, Françoise Porteu, William Vainchenker, Eric Solary
SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice. Leukemia (2023)
Violaine Havelange, Stefan N Constantinescu
Molecular pathogenesis of myeloproliferative neoplasms: Where do we stand in 2023? American journal of hematology (2023)
Jean-Philippe Defour, Emilie Leroy, Sharmila Dass, Thomas Balligand, Gabriel Levy, Ian C Brett, Nicolas Papadopoulos, Céline Mouton, Lidvine Genet, Christian Pecquet, Judith Staerk, Steven O Smith, Stefan N Constantinescu
Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers. eLife 12 (2023)
Nicolas Papadopoulos, Ajda Pristavec, Audrey Nédélec, Gabriel Levy, Judith Staerk, Stefan N Constantinescu
Modulation of Human Thrombopoietin Receptor Conformations Uncouples JAK2 V617F-Driven From Cytokine-Induced Activation. Blood (2023)
Nicolas Papadopoulos, Audrey Nédélec, Allison Derenne, Teodor Asvadur Şulea, Christian Pecquet, Ilyas Chachoua, Gaëlle Vertenoeil, Thomas Tilmant, Andrei-Jose Petrescu, Gabriel Mazzucchelli, Bogdan I Iorga, Didier Vertommen, Stefan N Constantinescu
Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation. Nature communications 14 (1) (2023)
Sara Lecomte, Julien Devreux, Grégoire de Streel, Nicolas van Baren, Violaine Havelange, David Schröder, Noora Vaherto, Christophe Vanhaver, Christophe Vanderaa, Noémie Dupuis, Christian Pecquet, Pierre G Coulie, Stefan N Constantinescu, Sophie Lucas
Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis. Blood (2022)
Gabriel Levy, Paola Guglielmelli, Peter Langmuir, Stefan N Constantinescu
JAK inhibitors and COVID-19. Journal for immunotherapy of cancer 10 (4) (2022)
Christian Pecquet, Nicolas Papadopoulos, Thomas Balligand, Ilyas Chachoua, Amandine Tisserand, Gaëlle Vertenoeil, Audrey Nédélec, Didier Vertommen, Anita Roy, Caroline Marty, Harini Nivarthi, Jean-Philippe Defour, Mira El-Khoury, Eva Hug, Andrea Majoros, Erica Xu, Oleh Zagrijtschuk, Tudor Emanuel Fertig, Daciana S Marta, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, Ilaria Carola Casetti, Elisa Rumi, Daniela Pietra, Chiara Cavalloni, Luca Arcaini, Mario Cazzola, Norio Komatsu, Yoshihiko Kihara, Yoshitaka Sunami, Yoko Edahiro, Marito Araki, Roman Lesyk, Veronika Buxhofer-Ausch, Sonja Heibl, Florence Pasquier, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N Constantinescu
Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms. Blood (2022)
Violaine Havelange, Stefan N Constantinescu
The 2 faces of ERK2 in MPNs. Blood 140 (4) (2022)
Leila N Varghese, Gonzalo Carreno-Tarragona, Gabriel Levy, Xabier Gutiérrez-López de Ocáriz, Inmaculada Rapado, Joaquín Martínez-López, Rosa María Ayala, Stefan N Constantinescu
MPL S505C enhances driver mutations at W515 in essential thrombocythemia. Blood cancer journal 11 (11) (2021)
Gonzalo Carreno-Tarragona, Leila N Varghese, Elena Sebastián, Eva Gálvez, Alberto Marín-Sánchez, Nieves López-Muñoz, Syonghyun Nam-Cha, Joaquín Martínez-López, Stefan N Constantinescu, Julian Sevilla, Rosa María Ayala
A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline. Leukemia 35 (11) (2021)
Camélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller, Philippe Rameau, Laure Touchard, Patrick Gonin, Stefan N Constantinescu, Hana Raslova, Jean-Luc Villeval, William Vainchenker, Isabelle Plo, Caroline Marty
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN. Nature communications 11 (1) (2020)
Mira El-Khoury, Xénia Cabagnols, Matthieu Mosca, Gaëlle Vertenoeil, Christophe Marzac, Fabrizia Favale, Olivier Bluteau, Florence Lorre, Amandine Tisserand, Graciela Rabadan Moraes, Valérie Ugo, Jean-Christophe Ianotto, Jerôme Rey, Eric Solary, Lydia Roy, Philippe Rameau, Najet Debili, Florence Pasquier, Nicole Casadevall, Caroline Marty, Stefan N Constantinescu, Hana Raslova, William Vainchenker, Isabelle Plo
Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms. Oncogene 39 (31) (2020)
Jean-Philippe Defour, Gabriel Levy, Emilie Leroy, Steven O Smith, Stefan N Constantinescu
The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters. Leukemia 33 (2) (2019)
Thomas Balligand, Younes Achouri, Christian Pecquet, Gilles Gaudray, Didier Colau, Eva Hug, Yacine Rahmani, Vincent Stroobant, Isabelle Plo, William Vainchenker, Robert Kralovics, Benoit J Van den Eynde, Jean-Philippe Defour, Stefan N Constantinescu
Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development. Leukemia 34 (2) (2019)
Christian Pecquet, Ilyas Chachoua, Anita Roy, Thomas Balligand, Gaëlle Vertenoeil, Emilie Leroy, Roxana-Irina Albu, Jean-Philippe Defour, Harini Nivarthi, Eva Hug, Erica Xu, Yasmine Ould-Amer, Céline Mouton, Didier Colau, Didier Vertommen, Myat Marlar Shwe, Caroline Marty, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N Constantinescu
Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants. Blood 133 (25) (2019)
Bettina Wingelhofer, Heidi A Neubauer, Peter Valent, Xiaonan Han, Stefan N Constantinescu, Patrick T Gunning, Mathias Müller, Richard H Moriggl
Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer. Leukemia 32 (8) (2018)
Katte Rao Toppaldoddi, Maira da Costa Cacemiro, Olivier Bluteau, Barbara Panneau-Schmaltz, Amélie Pioch, Delphine Muller, Jean-Luc Villeval, Hana Raslova, Stefan N Constantinescu, Isabelle Plo, William Vainchenker, Caroline Marty
Rare type 1-like and type 2-like calreticulin mutants induce similar myeloproliferative neoplasms as prevalent type 1 and 2 mutants in mice. Oncogene 38 (10) (2018)
Daniela Barbieri, Emilie Elvira-Matelot, Yanis Pelinski, Laetitia Genève, Bérengère de Laval, Gayathri Yogarajah, Christian Pecquet, Stefan N Constantinescu, Françoise Porteu
Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response. The Journal of experimental medicine 215 (5) (2018)

Stefan N Constantinescu.css-eqlu8i{font-size:small;padding-left:4px;} (Stefan Constantinescu)

Publication Activity (10 Years)

Top Topics

Top Venues

Stefan N Constantinescu (Stefan Constantinescu)