Thomas H Sharp

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 30

Top Venues

Nature communications

Journal of immunology (Baltimore, Md. : 1950)

Proceedings of the National Academy of Sciences of the United States of America

Journal of the American Chemical Society

Leids Universitair Medisch Centrum

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Leids Universitair Medisch Centrum Oct 01 2016

Netherlands

Independent researcher :: Molecular cell biology

Publications

Sebastiaan M W R Hamers, Aimee L Boyle, Thomas H Sharp
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation. Journal of immunology (Baltimore, Md. : 1950) 213 (2) (2024)
Sebastiaan M W R Hamers, Aimee L Boyle, Thomas H Sharp
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation. Journal of immunology (Baltimore, Md. : 1950) 213 (2) (2024)
Leoni Abendstein, Willem E M Noteborn, Luc S Veenman, Douwe J Dijkstra, Fleur S van de Bovenkamp, Leendert A Trouw, Thomas H Sharp
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation. Journal of the American Chemical Society 146 (19) (2024)
Roy Pattipeiluhu, Ye Zeng, Marco M R M Hendrix, Ilja Karina Voets, Alexander Kros, Thomas H Sharp
Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection. Nature communications 15 (1) (2024)
Stephanie A Schubert, Dina Ruano, Sebastien M Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M Pinto, Mar Rodríguez-Girondo, Daniela Q C M Barge-Schaapveld, Maartje Nielsen, Bernadette P M van Nesselrooij, Arjen R Mensenkamp, Monique E van Leerdam, Thomas H Sharp, Hans Morreau, Jean-Christophe Bourdon, Noel F C C de Miranda, J Tom van Wezel
Germline variant affecting p53β isoforms predisposes to familial cancer. Nature communications 15 (1) (2024)
Sebastiaan M W R Hamers, Aimee L Boyle, Thomas H Sharp
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation. Journal of immunology (Baltimore, Md. : 1950) 213 (2) (2024)
Roy Pattipeiluhu, Ye Zeng, Marco M R M Hendrix, Ilja Karina Voets, Alexander Kros, Thomas H Sharp
Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection. Nature communications 15 (1) (2024)
Sebastiaan M W R Hamers, Aimee L Boyle, Thomas H Sharp
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation. Journal of immunology (Baltimore, Md. : 1950) (2024)
Sebastiaan M W R Hamers, Leoni Abendstein, Aimee L Boyle, Seino A K Jongkees, Thomas H Sharp
Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system. RSC chemical biology 5 (8) (2024)
Dylan P Noone, Marjolein M E Isendoorn, Sebastiaan M W R Hamers, Mariska E Keizer, Jip Wulffelé, Tijn T van der Velden, Douwe J Dijkstra, Leendert Adrianus Trouw, Dmitri V Filippov, Thomas H Sharp
Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein. Proceedings of the National Academy of Sciences of the United States of America 121 (37) (2024)
Leoni Abendstein, Willem E M Noteborn, Luc S Veenman, Douwe J Dijkstra, Fleur S van de Bovenkamp, Leendert A Trouw, Thomas H Sharp
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation. Journal of the American Chemical Society 146 (19) (2024)
Leoni Abendstein, Willem E M Noteborn, Luc S Veenman, Douwe J Dijkstra, Fleur S van de Bovenkamp, Leendert A Trouw, Thomas H Sharp
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation. Journal of the American Chemical Society 146 (19) (2024)
Sebastiaan M W R Hamers, Leoni Abendstein, Aimee L Boyle, Seino A K Jongkees, Thomas H Sharp
Selection and characterization of a peptide-based complement modulator targeting C1 of the innate immune system. RSC chemical biology 5 (8) (2024)
Roy Pattipeiluhu, Ye Zeng, Marco M R M Hendrix, Ilja Karina Voets, Alexander Kros, Thomas H Sharp
Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection. Nature communications 15 (1) (2024)
Sebastiaan M W R Hamers, Aimee L Boyle, Thomas H Sharp
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation. Journal of immunology (Baltimore, Md. : 1950) (2024)
Leoni Abendstein, Willem E M Noteborn, Luc S Veenman, Douwe J Dijkstra, Fleur S van de Bovenkamp, Leendert A Trouw, Thomas H Sharp
DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation. Journal of the American Chemical Society (2024)
Mart G F Last, Lennard M Voortman, Thomas H Sharp
scNodes: a correlation and processing toolkit for super-resolution fluorescence and electron microscopy. Nature methods (2023)
Leoni Abendstein, Douwe J Dijkstra, Rayman T N Tjokrodirijo, Peter A van Veelen, Leendert Adrianus Trouw, Paul J Hensbergen, Thomas H Sharp
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains. Nature communications 14 (1) (2023)
Chenggong Ji, Hao Shen, Chen Su, Yaxin Li, Shihua Chen, Thomas H Sharp, Junyu Xiao
Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nature communications 14 (1) (2023)
Chenggong Ji, Hao Shen, Chen Su, Yaxin Li, Shihua Chen, Thomas H Sharp, Junyu Xiao
Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nature communications 14 (1) (2023)
Douwe J Dijkstra, Fleur S van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia S M Kramer, Linda M Slot, Jan Wouter Drijfhout, Lisanne de Vor, Kyra A Gelderman, Suzan H M Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H Sharp, Paul W H I Parren, Leendert Adrianus Trouw
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation. Proceedings of the National Academy of Sciences of the United States of America 120 (50) (2023)
Chenggong Ji, Hao Shen, Chen Su, Yaxin Li, Shihua Chen, Thomas H Sharp, Junyu Xiao
Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nature communications 14 (1) (2023)
Dylan P Noone, Douwe J Dijkstra, Teun T van der Klugt, Peter A van Veelen, Arnoud H de Ru, Paul J Hensbergen, Leendert A Trouw, Thomas H Sharp
PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation. Proceedings of the National Academy of Sciences of the United States of America 119 (33) (2022)
Roy Pattipeiluhu, Gabriela Arias-Alpizar, Genc Basha, Karen Y T Chan, Jeroen Bussmann, Thomas H Sharp, Mohammad-Amin Moradi, Nico A J M Sommerdijk, Edward N Harris, Pieter R Cullis, Alexander Kros, Dominik Witzigmann, Frederick Campbell
Anionic Lipid Nanoparticles Preferentially Deliver mRNA to the Hepatic Reticuloendothelial System. Advanced materials (Deerfield Beach, Fla.) 34 (16) (2022)
Maarten W Tuijtel, Abraham J Koster, Stefan Jakobs, Frank G A Faas, Thomas H Sharp
Author Correction: Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins. Scientific reports 12 (1) (2022)
Willem E M Noteborn, Leoni Abendstein, Thomas H Sharp
One-Pot Synthesis of Defined-Length ssDNA for Multiscaffold DNA Origami. Bioconjugate chemistry 32 (1) (2020)
Thomas H Sharp, Aimee L Boyle, Christoph A Diebolder, Alexander Kros, Abraham J Koster, Piet Gros
Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b. Proceedings of the National Academy of Sciences of the United States of America 116 (24) (2019)
Maarten W Tuijtel, Abraham J Koster, Stefan Jakobs, Frank G A Faas, Thomas H Sharp
Correlative cryo super-resolution light and electron microscopy on mammalian cells using fluorescent proteins. Scientific reports 9 (1) (2019)
Deniz Ugurlar, Stuart C Howes, Bart-Jan de Kreuk, Roman I Koning, Rob N de Jong, Frank J Beurskens, Janine Schuurman, Abraham J Koster, Thomas H Sharp, Paul W H I Parren, Piet Gros
Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science (New York, N.Y.) 359 (6377) (2018)
Maarten W Tuijtel, Aat A Mulder, Clara C Posthuma, Barbara van der Hoeven, Abraham J Koster, Montserrat Barcena, Frank G A Faas, Thomas H Sharp
Inducing fluorescence of uranyl acetate as a dual-purpose contrast agent for correlative light-electron microscopy with nanometre precision. Scientific reports 7 (1) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Thomas H Sharp