Paul W H I Parren (Paul Whi Parren)

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 20

Top Venues

Journal of immunology (Baltimore, Md. : 1950)

Proceedings of the National Academy of Sciences of the United States of America

Nature reviews. Drug discovery

Scientific reports

Lava Therapeutics BV

University of Amsterdam (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Lava Therapeutics BV May 01 2018

Netherlands

Executive Vice President, Head of R&D

Sparring Bioconsult BV Dec 01 2017

Netherlands

Owner

Leiden University Medical Center Jan 01 2015

Netherlands

Professor :: Immunohematology and Blood Transfusion

Syddansk Universitet Aug 01 2014 - Apr 30 2018

Denmark

Adjunct Professor :: Department of Molecular Medicine. Research Unit of Cancer and Inflammation Research

Genmab BV Jan 01 2002 - Dec 01 2017

Netherlands

Senior Vice President & Scientific Director

Education History

University of Amsterdam Sep 01 1987 - Jun 12 1992

Netherlands

PHD

University of Amsterdam Oct 01 1984 - May 27 1987

Netherlands

MSC

University of Amsterdam Sep 01 1981 - Sep 26 1984

Netherlands

BSC

Publications

Sigrid R Ruuls, Paul W H I Parren
Antibody avidity meets multiple myeloma. Nature cancer (2024)
Lisa A King, Elisa C Toffoli, Myrthe Veth, Victoria Iglesias-Guimarais, Manon C Slot, Derk Amsen, Rieneke van de Ven, Sarah Derks, Marieke F Fransen, Jurriaan B Tuynman, Thilo Riedl, Rob C Roovers, Anton E P Adang, Jurjen M Ruben, Paul W H I Parren, Tanja D de Gruijl, Hans J van der Vliet
A bispecific γδ T-cell engager targeting EGFR activates a potent Vγ9Vδ2 T cell-mediated immune response against EGFR-expressing tumors. Cancer immunology research (2023)
Douwe J Dijkstra, Fleur S van de Bovenkamp, Leoni Abendstein, Rob Zuijderduijn, Jos Pool, Cynthia S M Kramer, Linda M Slot, Jan Wouter Drijfhout, Lisanne de Vor, Kyra A Gelderman, Suzan H M Rooijakkers, Arnaud Zaldumbide, Gestur Vidarsson, Thomas H Sharp, Paul W H I Parren, Leendert Adrianus Trouw
Human anti-C1q autoantibodies bind specifically to solid-phase C1q and enhance phagocytosis but not complement activation. Proceedings of the National Academy of Sciences of the United States of America 120 (50) (2023)
Willemijn van der Wulp, Dennis F G Remst, Michel G D Kester, Renate S Hagedoorn, Paul W H I Parren, Sander I van Kasteren, Janine Schuurman, Wytske M van Weerden, Maaike E Ressing, Boris Bleijlevens, Mirjam H M Heemskerk
Antibody-mediated delivery of viral epitopes to redirect EBV-specific CD8 + T-cell immunity towards cancer cells. Cancer gene therapy (2023)
Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Yoheswaran Nielsen, Henriette Vever, Soren Wk Hansen, Morten Frier Gjerstorff, Christa Elisabeth Müller, Paul W H I Parren, Henrik Jørn Ditzel
Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity. Journal for immunotherapy of cancer 10 (9) (2022)
Simone C Oostindie, Greg A Lazar, Janine Schuurman, Paul W H I Parren
Avidity in antibody effector functions and biotherapeutic drug design. Nature reviews. Drug discovery 21 (10) (2022)
Iris de Weerdt, Roeland Lameris, Jurjen M Ruben, Renate de Boer, Jan Kloosterman, Lisa A King, Mark-David Levin, Paul W H I Parren, Tanja D de Gruijl, Arnon P Kater, Hans J van der Vliet
A Bispecific Single-Domain Antibody Boosts Autologous Vγ9Vδ2-T Cell Responses Toward CD1d in Chronic Lymphocytic Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (6) (2021)
Dana L E Vergoossen, Jaap J Plomp, Christoph Gstöttner, Yvonne E Fillié-Grijpma, Roy Augustinus, Robyn Verpalen, Manfred Wuhrer, Paul W H I Parren, Elena Domínguez-Vega, Silvère M van der Maarel, Jan J Verschuuren, Maartje G Huijbers
Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis. Proceedings of the National Academy of Sciences of the United States of America 118 (13) (2021)
Aran F Labrijn, Maarten L Janmaat, Janice M Reichert, Paul W H I Parren
Bispecific antibodies: a mechanistic review of the pipeline. Nature reviews. Drug discovery 18 (8) (2020)
Marije B Overdijk, Kristin Strumane, Frank J Beurskens, Antonio Ortiz Buijsse, Claudine Vermot-Desroches, Boris S Vuillermoz, Thessa Kroes, Rob N de Jong, Naomi Hoevenaars, Richard G Hibbert, Andreas Lingnau, Ulf Forssmann, Janine Schuurman, Paul W H I Parren, Esther C W Breij
Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism. Molecular cancer therapeutics 19 (10) (2020)
Iris de Weerdt, Roeland Lameris, George L Scheffer, Jana Vree, Renate de Boer, Anita G Stam, Rieneke van de Ven, Mark-David Levin, Steven T Pals, Rob C Roovers, Paul W H I Parren, Tanja D de Gruijl, Arnon P Kater, Hans J van der Vliet
A Bispecific Antibody Antagonizes Prosurvival CD40 Signaling and Promotes Vγ9Vδ2 T cell-Mediated Antitumor Responses in Human B-cell Malignancies. Cancer immunology research 9 (1) (2020)
Patrick J Engelberts, Esther C W Breij, Thomas Valerius, Janine Schuurman, Paul W H I Parren, Frank J Beurskens
Response to Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells". Journal of immunology (Baltimore, Md. : 1950) 200 (8) (2019)
Deniz Ugurlar, Stuart C Howes, Bart-Jan de Kreuk, Roman I Koning, Rob N de Jong, Frank J Beurskens, Janine Schuurman, Abraham J Koster, Thomas H Sharp, Paul W H I Parren, Piet Gros
Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science (New York, N.Y.) 359 (6377) (2018)
Julia Boshuizen, Louise A Koopman, Oscar Krijgsman, Aida Shahrabi, Elke Gresnigt- van den Heuvel, Maarten A Ligtenberg, David W Vredevoogd, Kristel Kemper, Thomas Kuilman, Ji-Ying Song, Nora Pencheva, Jens Thing Mortensen, Marnix Geukes Foppen, Elisa A Rozeman, Christian U Blank, Maarten L Janmaat, David Satijn, Esther C W Breij, Daniel S Peeper, Paul W H I Parren
Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors. Nature medicine 24 (2) (2018)
Annalina Tammen, Stefanie Derer, Ralf Schwanbeck, Thies Rösner, Anna Kretschmer, Frank J Beurskens, Janine Schuurman, Paul W H I Parren, Thomas Valerius
Monoclonal Antibodies against Epidermal Growth Factor Receptor Acquire an Ability To Kill Tumor Cells through Complement Activation by Mutations That Selectively Facilitate the Hexamerization of IgG on Opsonized Cells. Journal of immunology (Baltimore, Md. : 1950) 198 (4) (2017)
Mario Losen, Aran F Labrijn, Vivianne H van Kranen-Mastenbroek, Maarten L Janmaat, Krista G Haanstra, Frank J Beurskens, Tom Vink, Margreet Jonker, Bert A 't Hart, Marina Mané-Damas, Peter C Molenaar, Pilar Martinez-Martinez, Eline van der Esch, Janine Schuurman, Marc H de Baets, Paul W H I Parren
Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys. Scientific reports 7 (1) (2017)
Aran F Labrijn, Joyce I Meesters, Matthew Bunce, Anthony A Armstrong, Sandeep Somani, Tom C Nesspor, Mark L Chiu, Işil Altintaş, Sandra Verploegen, Janine Schuurman, Paul W H I Parren
Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models. Scientific reports 7 (1) (2017)
Marije B Overdijk, J H Marco Jansen, Maaike Nederend, Jeroen J Lammerts van Bueren, Richard W J Groen, Paul W H I Parren, Jeanette H W Leusen, Peter Boross
The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor-Mediated Cross-Linking. Journal of immunology (Baltimore, Md. : 1950) 197 (3) (2016)
Patrick J Engelberts, Marleen Voorhorst, Janine Schuurman, Tom van Meerten, Joost M Bakker, Tom Vink, Wendy J M Mackus, Esther C W Breij, Stefanie Derer, Thomas Valerius, Jan G J van de Winkel, Paul W H I Parren, Frank J Beurskens
Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells. Journal of immunology (Baltimore, Md. : 1950) 197 (12) (2016)
Erika M Cook, Margaret A Lindorfer, Hilma van der Horst, Simone Oostindie, Frank J Beurskens, Janine Schuurman, Clive S Zent, Richard Burack, Paul W H I Parren, Ronald P Taylor
Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions. Journal of immunology (Baltimore, Md. : 1950) 197 (5) (2016)

Paul W H I Parren.css-eqlu8i{font-size:small;padding-left:4px;} (Paul Whi Parren)

Publication Activity (10 Years)

Top Topics

Top Venues

Paul W H I Parren (Paul Whi Parren)