Thomas L Poulos

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 29

Top Topics

Structural Basis

Pluripotent Stem Cells

Molecular Dynamics

Top Venues

Journal of medicinal chemistry

Journal of the American Chemical Society

Accounts of chemical research

This page only lists publications with an associated author ORCID identifier.

Publications

Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Jessica A Gable, Thomas L Poulos, Alec H Follmer
Cooperative Substrate Binding Controls Catalysis in Bacterial Cytochrome P450terp (CYP108A1). Journal of the American Chemical Society (2023)
Dhananjayan Vasu, Ha T Do, Huiying Li, Christine D Hardy, Amardeep Awasthi, Thomas L Poulos, Richard B Silverman
Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. Journal of medicinal chemistry (2023)
Jessica A Gable, Sarvind M Tripathi, Thomas L Poulos
Structural Insights on the Conversion of Cytochrome P450 to P420. ACS omega 7 (22) (2022)
Thomas L Poulos, Jenny S Kim, Vidhi C Murarka
Computational analysis of the tryptophan cation radical energetics in peroxidase Compound I. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 27 (2) (2022)
Simon P Skinner, Alec H Follmer, Marcellus Ubbink, Thomas L Poulos, Jeanine J Houwing-Duistermaat, Emanuele Paci
Partial Opening of Cytochrome P450cam (CYP101A1) Is Driven by Allostery and Putidaredoxin Binding. Biochemistry 60 (39) (2021)
Thomas L Poulos, Alec H Follmer
Updating the Paradigm: Redox Partner Binding and Conformational Dynamics in Cytochromes P450. Accounts of chemical research 55 (3) (2021)
Maris A Cinelli, Cory T Reidl, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. Journal of medicinal chemistry 63 (9) (2020)
Vidhi C Murarka, Dipanwita Batabyal, Jose A Amaya, Irina F Sevrioukova, Thomas L Poulos
Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases. Biochemistry 59 (29) (2020)
José A Amaya, Dipanwita Batabyal, Thomas L Poulos
Proton Relay Network in the Bacterial P450s: CYP101A1 and CYP101D1. Biochemistry 59 (31) (2020)
Maris A Cinelli, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of medicinal chemistry 62 (2) (2019)
Shih-Wei Chuo, Shu-Hao Liou, Lee-Ping Wang, R David Britt, Thomas L Poulos, Irina F Sevrioukova, David B Goodin
Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution. Biochemistry 58 (37) (2019)
Ha T Do, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. Journal of medicinal chemistry 62 (5) (2019)
Alec H Follmer, Sarvind M Tripathi, Thomas L Poulos
Ligand and Redox Partner Binding Generates a New Conformational State in Cytochrome P450cam (CYP101A1). Journal of the American Chemical Society 141 (6) (2019)
Huiying Li, Ryan J Evenson, Georges Chreifi, Richard B Silverman, Thomas L Poulos
Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides. Biochemistry 57 (44) (2018)
Ha T Do, Heng-Yen Wang, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Correction to Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of medicinal chemistry 62 (2) (2018)
Alec H Follmer, Mavish Mahomed, David B Goodin, Thomas L Poulos
Substrate-Dependent Allosteric Regulation in Cytochrome P450cam (CYP101A1). Journal of the American Chemical Society 140 (47) (2018)
Ariel Lewis-Ballester, Shay Karkashon, Dipanwita Batabyal, Thomas L Poulos, Syun-Ru Yeh
Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1. Journal of the American Chemical Society 140 (27) (2018)
Sarvind Tripathi, Thomas L Poulos
Testing the N-Terminal Velcro Model of CooA Carbon Monoxide Activation. Biochemistry 57 (21) (2018)
Dipanwita Batabyal, Logan S Richards, Thomas L Poulos
Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. Journal of the American Chemical Society 139 (37) (2017)
Ha T Do, Heng-Yen Wang, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of medicinal chemistry 60 (22) (2017)
Scott A Hollingsworth, Brian D Nguyen, Georges Chreifi, Anton P Arce, Thomas L Poulos
Insights into the Dynamics and Dissociation Mechanism of a Protein Redox Complex Using Molecular Dynamics. Journal of chemical information and modeling 57 (9) (2017)
Maris A Cinelli, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of medicinal chemistry 60 (9) (2017)
Anthony V Pensa, Maris A Cinelli, Huiying Li, Georges Chreifi, Paramita Mukherjee, Linda J Roman, Pavel Martásek, Thomas L Poulos, Richard B Silverman
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. Journal of medicinal chemistry 60 (16) (2017)
Abdelkrim Benabbas, Yuhan Sun, Thomas L Poulos, Paul M Champion
Ultrafast CO Kinetics in Heme Proteins: Adiabatic Ligand Binding and Heavy Atom Tunneling. Journal of the American Chemical Society 139 (44) (2017)