Richard B Silverman

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 56

Top Topics

Structural Basis

Amyotrophic Lateral Sclerosis

Top Venues

ACS chemical biology

Journal of medicinal chemistry

Journal of the American Chemical Society

This page only lists publications with an associated author ORCID identifier.

Publications

Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology 19 (5) (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology 19 (5) (2024)
Adrian O Dukes, Pathum M Weerawarna, Allison N Devitt, Richard B Silverman
Synthesis of (2 R ,4 S )-4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction. The Journal of organic chemistry (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology 19 (5) (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology 19 (5) (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Adrian O Dukes, Pathum M Weerawarna, Allison N Devitt, Richard B Silverman
Synthesis of (2 R ,4 S )-4-Amino-5-hydroxybicyclo[3.1.1]heptane-2-carboxylic Acid via an Asymmetric Intramolecular Mannich Reaction. The Journal of organic chemistry 89 (12) (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Correction to "Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase". ACS chemical biology 19 (8) (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology (2024)
Huiying Li, Christine D Hardy, Cory T Reidl, Qing Jing, Fengtian Xue, Maris A Cinelli, Richard B Silverman, Thomas L Poulos
Crystallographic and Computational Insights into Isoform-Selective Dynamics in Nitric Oxide Synthase. Biochemistry 63 (6) (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Correction to "Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase". ACS chemical biology (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology 19 (5) (2024)
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio Monteiro Ferreira, Graham R Moran, Michael P Snyder, Dali Liu, Richard B Silverman
Design, Synthesis, and Mechanistic Studies of ( R )-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase. ACS chemical biology 19 (5) (2024)
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio Monteiro Ferreira, Peter Francis Doubleday, Daniel H Grass, Wei Zhu, Neil L Kelleher, Graham R Moran, Dali Liu, Richard B Silverman
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules (Basel, Switzerland) 28 (3) (2023)
Mohamed F Elmansy, Cory T Reidl, Mizzanoor Rahaman, P Hande Özdinler, Richard B Silverman
Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis. Medicinal research reviews (2023)
Pathum M Weerawarna, Isaac T Schiefer, Pedro Soares, Susan Fox, Richard I Morimoto, Rafael D Melani, Michael P Snyder, Chi-Hao Luan, Richard B Silverman
Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis. ACS central science 10 (1) (2023)
Pathum M Weerawarna, Isaac T Schiefer, Pedro Soares, Susan Fox, Richard I Morimoto, Rafael D Melani, Michael P Snyder, Chi-Hao Luan, Richard B Silverman
Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis. ACS central science 10 (1) (2023)
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio Monteiro Ferreira, Peter Francis Doubleday, Daniel H Grass, Wei Zhu, Neil L Kelleher, Graham R Moran, Dali Liu, Richard B Silverman
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules (Basel, Switzerland) 28 (3) (2023)
Pathum M Weerawarna, Isaac T Schiefer, Pedro Soares, Susan Fox, Richard I Morimoto, Rafael D Melani, Michael P Snyder, Chi-Hao Luan, Richard B Silverman
Target Identification of a Class of Pyrazolone Protein Aggregation Inhibitor Therapeutics for Amyotrophic Lateral Sclerosis. ACS central science 10 (1) (2023)
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio Monteiro Ferreira, Peter Francis Doubleday, Daniel H Grass, Wei Zhu, Neil L Kelleher, Graham R Moran, Dali Liu, Richard B Silverman
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules (Basel, Switzerland) 28 (3) (2023)
Wei Zhu, Arseniy Butrin, Rafael D Melani, Peter Francis Doubleday, Glaucio Monteiro Ferreira, Maurício Temotheo Tavares, Thahani S Habeeb Mohammad, Brett A Beaupre, Michael P Snyder, Graham R Moran, Dali Liu, Richard B Silverman
Correction to "Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase". Journal of the American Chemical Society (2023)
Dhananjayan Vasu, Ha T Do, Huiying Li, Christine D Hardy, Amardeep Awasthi, Thomas L Poulos, Richard B Silverman
Potent, Selective, and Membrane Permeable 2-Amino-4-Substituted Pyridine-Based Neuronal Nitric Oxide Synthase Inhibitors. Journal of medicinal chemistry (2023)
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio Monteiro Ferreira, Peter Francis Doubleday, Daniel H Grass, Wei Zhu, Neil L Kelleher, Graham R Moran, Dali Liu, Richard B Silverman
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules (Basel, Switzerland) 28 (3) (2023)
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio Monteiro Ferreira, Peter Francis Doubleday, Daniel H Grass, Wei Zhu, Neil L Kelleher, Graham R Moran, Dali Liu, Richard B Silverman
Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3 S ,4 S )-3-Amino-4-fluorocyclopentenecarboxylic Acid. Molecules (Basel, Switzerland) 28 (3) (2023)
Shirley Tong, Shaban Darwish, Hanieh Hossein Nejad Ariani, Kate Alison Lozada, David Salehi, Maris A Cinelli, Richard B Silverman, Kamaljit Kaur, Sun Yang
A Small Peptide Increases Drug Delivery in Human Melanoma Cells. Pharmaceutics 14 (5) (2022)
Wei Zhu, Arseniy Butrin, Rafael Donadélli Melani, Peter Francis Doubleday, Glaucio Monteiro Ferreira, Maurício Temotheo Tavares, Thahani S Habeeb Mohammad, Brett A Beaupre, Michael P Snyder, Graham R Moran, Dali Liu, Richard B Silverman
Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. Journal of the American Chemical Society 144 (12) (2022)
Jisu Yun, Dayeon Jeong, Zhong Xie, Sol Lee, Jiho Kim, D James Surmeier, Richard B Silverman, Soosung Kang
Palladium-Catalyzed α-Arylation of Cyclic β-Dicarbonyl Compounds for the Synthesis of Ca V 1.3 Inhibitors. ACS omega 7 (16) (2022)
Richard B Silverman
Inactivators of Ornithine Aminotransferase for the Treatment of Hepatocellular Carcinoma. ACS medicinal chemistry letters 13 (1) (2021)
Pathum M Weerawarna, Matthew J Moschitto, Richard B Silverman
Theoretical and Mechanistic Validation of Global Kinetic Parameters of the Inactivation of GABA Aminotransferase by OV329 and CPP-115. ACS chemical biology 16 (4) (2021)
Wei Zhu, Peter F Doubleday, Arseniy Butrin, Pathum M Weerawarna, Rafael D Melani, Daniel S Catlin, Timothy A Dwight, Dali Liu, Michael P Snyder, Richard B Silverman
Remarkable and Unexpected Mechanism for (S)-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. Journal of the American Chemical Society 143 (21) (2021)
Garry Cooper, Soosung Kang, Tamara Perez-Rosello, Jaime N Guzman, Daniel Galtieri, Zhong Xie, Jyothisri Kondapalli, Jack Mordell, Richard B Silverman, D James Surmeier
Correction to A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels. ACS chemical biology 16 (7) (2021)
Sida Shen, Arseniy Butrin, Peter F Doubleday, Rafael D Melani, Brett A Beaupre, Mauricio T Tavares, Glaucio Monteiro Ferreira, Michael P Snyder, Graham R Moran, Dali Liu, Richard B Silverman
Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase. Journal of the American Chemical Society 143 (23) (2021)
Maris A Cinelli, Cory T Reidl, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. Journal of medicinal chemistry 63 (9) (2020)
Wei Zhu, Peter F Doubleday, Daniel S Catlin, Pathum M Weerawarna, Arseniy Butrin, Sida Shen, Zdzislaw Wawrzak, Michael P Snyder, Dali Liu, Richard B Silverman
A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. Journal of the American Chemical Society 142 (10) (2020)
Lena F Burbulla, Sohee Jeon, Jianbin Zheng, Pingping Song, Richard B Silverman, Dimitri Krainc
A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson's disease. Science translational medicine 11 (514) (2020)
Arseniy Butrin, Brett A Beaupre, Noel Kadamandla, Peidong Zhao, Sida Shen, Richard B Silverman, Graham R Moran, Dali Liu
Structural and Kinetic Analyses Reveal the Dual Inhibition Modes of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)-cyclopentane-1-carboxylic Acid (BCF3). ACS chemical biology 16 (1) (2020)
Garry Cooper, Soosung Kang, Tamara Perez-Rosello, Jaime N Guzman, Daniel Galtieri, Zhong Xie, Jyothisri Kondapalli, Jack Mordell, Richard B Silverman, D James Surmeier
A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels. ACS chemical biology 15 (9) (2020)
Maris A Cinelli, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Correction to Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of medicinal chemistry 62 (2) (2019)
Jianbin Zheng, Sohee Jeon, Weilan Jiang, Lena F Burbulla, Daniel Ysselstein, Kristine Oevel, Dimitri Krainc, Richard B Silverman
Correction to Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of medicinal chemistry 62 (5) (2019)
Jianbin Zheng, Sohee Jeon, Weilan Jiang, Lena F Burbulla, Daniel Ysselstein, Kristine Oevel, Dimitri Krainc, Richard B Silverman
Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. Journal of medicinal chemistry 62 (3) (2019)
Ha T Do, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold. Journal of medicinal chemistry 62 (5) (2019)
Maris A Cinelli, Ha T Do, Galen P Miley, Richard B Silverman
Inducible nitric oxide synthase: Regulation, structure, and inhibition. Medicinal research reviews 40 (1) (2019)
Richard B Silverman
Design and Mechanism of GABA Aminotransferase Inactivators. Treatments for Epilepsies and Addictions. Chemical reviews 118 (7) (2018)
Huiying Li, Ryan J Evenson, Georges Chreifi, Richard B Silverman, Thomas L Poulos
Structural Basis for Isoform Selective Nitric Oxide Synthase Inhibition by Thiophene-2-carboximidamides. Biochemistry 57 (44) (2018)
Matthew J Moschitto, Richard B Silverman
Synthesis of ( S)-3-Amino-4-(difluoromethylenyl)-cyclopent-1-ene-1-carboxylic Acid (OV329), a Potent Inactivator of γ-Aminobutyric Acid Aminotransferase. Organic letters 20 (15) (2018)
Galen P Miley, Jennifer C Rote, Richard B Silverman, Michael P Snyder, Regan J Thomson
Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization. Organic letters 20 (8) (2018)
Jose I Juncosa, Kenji Takaya, Hoang V Le, Matthew J Moschitto, Pathum M Weerawarna, Romila Mascarenhas, Dali Liu, Stephen L Dewey, Richard B Silverman
Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction. Journal of the American Chemical Society 140 (6) (2018)
Ha T Do, Heng-Yen Wang, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker. Journal of medicinal chemistry 60 (22) (2017)
Romila Mascarenhas, Hoang V Le, Kenneth D Clevenger, Helaina J Lehrer, Dagmar Ringe, Michael P Snyder, Richard B Silverman, Dali Liu
Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry 56 (37) (2017)
Maris A Cinelli, Huiying Li, Georges Chreifi, Thomas L Poulos, Richard B Silverman
Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of medicinal chemistry 60 (9) (2017)
Anthony V Pensa, Maris A Cinelli, Huiying Li, Georges Chreifi, Paramita Mukherjee, Linda J Roman, Pavel Martásek, Thomas L Poulos, Richard B Silverman
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. Journal of medicinal chemistry 60 (16) (2017)
Romila Mascarenhas, Hoang V Le, Kenneth D Clevenger, Helaina J Lehrer, Dagmar Ringe, Michael P Snyder, Richard B Silverman, Dali Liu
Correction to Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry 56 (43) (2017)