Timothy J Egan

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 20

Top Topics

Plasmodium Falciparum

Top Venues

Journal of medicinal chemistry

ACS infectious diseases

Accounts of chemical research

Inorganic chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J Wicht, Lubbe Wiesner, Timothy J Egan, Kelly Chibale
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum , and Synergize with Clinical Antimalarials. ACS infectious diseases 9 (3) (2023)
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J Wicht, Lubbe Wiesner, Timothy J Egan, Kelly Chibale
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum , and Synergize with Clinical Antimalarials. ACS infectious diseases 9 (3) (2023)
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J Wicht, Lubbe Wiesner, Timothy J Egan, Kelly Chibale
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum , and Synergize with Clinical Antimalarials. ACS infectious diseases (2023)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry 65 (24) (2022)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry 65 (24) (2022)
Constance Mawunyo Korkor, Larnelle F Garnie, Leah Amod, Timothy J Egan, Kelly Chibale
Intrinsic fluorescence properties of antimalarial pyrido[1,2-a]benzimidazoles facilitate subcellular accumulation and mechanistic studies in the human malaria parasite Plasmodium falciparum. Organic & biomolecular chemistry 18 (42) (2022)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry 65 (24) (2022)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry (2022)
Abdolkarim Farrokhzadeh, Farideh Badichi Akher, Timothy J Egan
Molecular Mechanism Exploration of Potent Fluorinated PI3K Inhibitors with a Triazine Scaffold: Unveiling the Unusual Synergistic Effect of Pyridine-to-Pyrimidine Ring Interconversion and CF3 Defluorination. The journal of physical chemistry. B 125 (36) (2021)
Roxanne Openshaw, Keletso Maepa, Stefan J Benjamin, Lauren Wainwright, Jill M Combrinck, Roger Hunter, Timothy J Egan
A Diverse Range of Hemozoin Inhibiting Scaffolds Act on Plasmodium falciparum as Heme Complexes. ACS infectious diseases 7 (2) (2021)
Katherine Allison de Villiers, Timothy J Egan
Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development. Accounts of chemical research 54 (11) (2021)
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C de Sousa, John Okombo, Keletso Maepa, Timothy J Egan, Lyn-Marie Birkholtz, Gregory S Basarab, Sergio Wittlin, Paul V Fish, Leslie J Street, James Duffy, Kelly Chibale
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model". Journal of medicinal chemistry 64 (3) (2021)
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C de Sousa, John Okombo, Keletso Maepa, Timothy J Egan, Lyn-Marie Birkholtz, Gregory S Basarab, Sergio Wittlin, Paul V Fish, Leslie J Street, James Duffy, Kelly Chibale
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model. Journal of medicinal chemistry 63 (21) (2020)
Malkeet Kumar, John Okombo, Dickson Mambwe, Dale Taylor, Nina Lawrence, Janette Reader, Mariëtte van der Watt, Diana Fontinha, Margarida Sanches-Vaz, Belinda C Bezuidenhout, Sonja B Lauterbach, Dale Liebenberg, Lyn-Marie Birkholtz, Theresa L Coetzer, Miguel Prudêncio, Timothy J Egan, Sergio Wittlin, Kelly Chibale
Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action. ACS infectious diseases 5 (2) (2019)
Godfrey Mayoka, Mathew Njoroge, John Okombo, Liezl Gibhard, Margarida Sanches-Vaz, Diana Fontinha, Lyn-Marie Birkholtz, Janette Reader, Mariëtte van der Watt, Theresa L Coetzer, Sonja Lauterbach, Alisje Churchyard, Belinda Bezuidenhout, Timothy J Egan, Clive Yeates, Sergio Wittlin, Miguel Prudêncio, Kelly Chibale
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria. Journal of medicinal chemistry 62 (2) (2018)
John G Woodland, Roger Hunter, Peter J Smith, Timothy J Egan
Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and Lipids. ACS chemical biology 13 (10) (2018)
Nicola A Dare, Lee Brammer, Susan A Bourne, Timothy J Egan
Fe(III) Protoporphyrin IX Encapsulated in a Zinc Metal-Organic Framework Shows Dramatically Enhanced Peroxidatic Activity. Inorganic chemistry 57 (3) (2018)
Mukesh C Joshi, John Okombo, Samkele Nsumiwa, Jeffrey Ndove, Dale Taylor, Lubbe Wiesner, Roger Hunter, Kelly Chibale, Timothy J Egan
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice. Journal of medicinal chemistry 60 (24) (2017)
John Okombo, Kawaljit Singh, Godfrey Mayoka, Ferdinand Ndubi, Linley Barnard, Peter M Njogu, Mathew Njoroge, Liezl Gibhard, Christel Brunschwig, Mireille Vargas, Jennifer Keiser, Timothy J Egan, Kelly Chibale
Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation. ACS infectious diseases 3 (6) (2017)
Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L Coetzer, Jeremy N Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J Egan, Sergio Wittlin, Kelly Chibale
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model. Journal of medicinal chemistry 60 (4) (2017)