Paul V Fish

ORCID

Publication Activity (10 Years)

Years Active: 2017-2022
Publications (10 Years): 17

Top Venues

Journal of medicinal chemistry

Beilstein journal of organic chemistry

ACS chemical biology

RSC advances

This page only lists publications with an associated author ORCID identifier.

Publications

Nicky J Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L Woodward, Benjamin N Atkinson, Elliott David Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R Ruza, Svend Kjær, Steven Howell, Ambrosius P Snijders, Magda Bictash, Patricia C Salinas, Jean-Paul Vincent, Edith Yvonne Jones, Paul Whiting, Paul V Fish
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. Journal of medicinal chemistry 65 (10) (2022)
Yuguang Zhao, William Mahy, Nicky J Willis, Hannah L Woodward, David Steadman, Elliott D Bayle, Benjamin N Atkinson, James Sipthorp, Luca Vecchia, Reinis R Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C Salinas, Paul Whiting, Jean-Paul Vincent, Paul V Fish, Edith Yvonne Jones
Structural Analysis and Development of Notum Fragment Screening Hits. ACS chemical neuroscience 13 (13) (2022)
Benjamin N Atkinson, Nicky J Willis, Jennifer Smith, Rebecca Gill, Jody Ali, Zhou Xu, Ping-Shan Lai, Paul V Fish
Large-scale synthesis of Notum inhibitor 1-(2,4-dichloro-3-(trifluoromethyl)-phenyl)-1 H -1,2,3-triazole (ARUK3001185) employing a modified Sakai reaction as the key step. RSC advances 12 (41) (2022)
Yuguang Zhao, Sarah Jolly, Stefano Benvegnu, Edith Yvonne Jones, Paul V Fish
Small-molecule inhibitors of carboxylesterase Notum. Future medicinal chemistry 13 (11) (2021)
Elliott D Bayle, Fredrik Svensson, Benjamin N Atkinson, David Steadman, Nicky J Willis, Hannah L Woodward, Paul Whiting, Jean-Paul Vincent, Paul V Fish
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling. Journal of medicinal chemistry 64 (8) (2021)
David Steadman, Benjamin N Atkinson, Yuguang Zhao, Nicky J Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, Edith Yvonne Jones, Paul V Fish, Fredrik Svensson
Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity. Journal of medicinal chemistry 65 (1) (2021)
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C de Sousa, John Okombo, Keletso Maepa, Timothy J Egan, Lyn-Marie Birkholtz, Gregory S Basarab, Sergio Wittlin, Paul V Fish, Leslie J Street, James Duffy, Kelly Chibale
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model". Journal of medicinal chemistry 64 (3) (2021)
William Mahy, Mikesh Patel, David Steadman, Hannah L Woodward, Benjamin N Atkinson, Fredrik Svensson, Nicky J Willis, Alister Flint, Dimitra Papatheodorou, Yuguang Zhao, Luca Vecchia, Reinis R Ruza, James Hillier, Sarah Frew, Amy Monaghan, Artur Costa, Magda Bictash, Magnus W Walter, Edith Yvonne Jones, Paul V Fish
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity. Journal of medicinal chemistry 63 (17) (2020)
William Mahy, Nicky J Willis, Yuguang Zhao, Hannah L Woodward, Fredrik Svensson, James Sipthorp, Luca Vecchia, Reinis R Ruza, James Hillier, Svend Kjær, Sarah Frew, Amy Monaghan, Magda Bictash, Patricia C Salinas, Paul Whiting, Jean-Paul Vincent, E Yvonne Jones, Paul V Fish
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit. Journal of medicinal chemistry 63 (21) (2020)
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C de Sousa, John Okombo, Keletso Maepa, Timothy J Egan, Lyn-Marie Birkholtz, Gregory S Basarab, Sergio Wittlin, Paul V Fish, Leslie J Street, James Duffy, Kelly Chibale
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model. Journal of medicinal chemistry 63 (21) (2020)
Nicky J Willis, Elliott D Bayle, George Papageorgiou, David Steadman, Benjamin N Atkinson, William Mahy, Paul V Fish
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent. Beilstein journal of organic chemistry 15 (2019)
Benjamin N Atkinson, David Steadman, Yuguang Zhao, James Sipthorp, Luca Vecchia, Reinis R Ruza, Fiona Jeganathan, Georgie Lines, Sarah Frew, Amy Monaghan, Svend Kjær, Magda Bictash, Edith Yvonne Jones, Paul V Fish
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. MedChemComm 10 (8) (2019)
Claire Le Manach, Tanya Paquet, Kathryn Wicht, Aloysius T Nchinda, Christel Brunschwig, Mathew Njoroge, Liezl Gibhard, Dale Taylor, Nina Lawrence, Sergio Wittlin, Charles J Eyermann, Gregory S Basarab, James Duffy, Paul V Fish, Leslie J Street, Kelly Chibale
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains. Journal of medicinal chemistry 61 (20) (2018)
Benjamin N Atkinson, Hannah L Woodward, James Sipthorp, Paul V Fish
Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives. Organic & biomolecular chemistry 15 (46) (2018)
Julia C Meier, Cynthia Tallant, Oleg Fedorov, Hanna Witwicka, Sung-Yong Hwang, Ruud G van Stiphout, Jean-Philippe Lambert, Catherine Rogers, Clarence Yapp, Brian S Gerstenberger, Vita Fedele, Pavel Savitsky, David Heidenreich, Danette L Daniels, Dafydd R Owen, Paul V Fish, Niall M Igoe, Elliott D Bayle, Bernard Haendler, Udo C T Oppermann, Francesca Buffa, Paul E Brennan, Susanne Müller, Anne Claude Gingras, Paul R Odgren, Mark J Birnbaum, Stefan Knapp
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation. ACS chemical biology 12 (10) (2017)
Niall Igoe, Elliott D Bayle, Cynthia Tallant, Oleg Fedorov, Julia C Meier, Pavel Savitsky, Catherine Rogers, Yannick Morias, Sarah Scholze, Helen Boyd, Danen Cunoosamy, David M Andrews, Anne Cheasty, Paul E Brennan, Susanne Müller, Stefan Knapp, Paul V Fish
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins. Journal of medicinal chemistry 60 (16) (2017)
Niall Igoe, Elliott D Bayle, Oleg Fedorov, Cynthia Tallant, Pavel Savitsky, Catherine Rogers, Dafydd R Owen, Gauri Deb, Tim C P Somervaille, David M Andrews, Neil Jones, Anne Cheasty, Hamish Ryder, Paul E Brennan, Susanne Müller, Stefan Knapp, Paul V Fish
Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. Journal of medicinal chemistry 60 (2) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Paul V Fish