Kelly Chibale

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 99

Top Topics

Plasmodium Falciparum

Top Venues

ACS infectious diseases

Journal of medicinal chemistry

ACS medicinal chemistry letters

Accounts of chemical research

This page only lists publications with an associated author ORCID identifier.

Publications

Dickson Mambwe, Dina Coertzen, Meta Leshabane, Mwila Mulubwa, Mathew Njoroge, Liezl Gibhard, Gareth Girling, Kathryn J Wicht, Marcus C S Lee, Sergio Wittlin, Diogo Rodrigo de Magalhães Moreira, Lyn-Marié Birkholtz, Kelly Chibale
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole. ACS medicinal chemistry letters 15 (4) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
David E Heppner, Simone V Bigi-Botterill, Andrew P Riley, Kelly Chibale, Dennis C Liotta
Structural Biology in Drug Discovery and Development: Call for Papers. Journal of medicinal chemistry 67 (15) (2024)
Jessica A Collins, Gregory S Basarab, Kelly Chibale, Neil Osheroff
Interactions between Zoliflodacin and Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS infectious diseases 10 (8) (2024)
Jason Hlozek, Kelly Chibale, John G Woodland
Ongoing Implementation and Prospective Validation of Artificial Intelligence/Machine Learning Tools at an African Drug Discovery Center. ACS medicinal chemistry letters 15 (7) (2024)
Dickson Mambwe, Dina Coertzen, Meta Leshabane, Mwila Mulubwa, Mathew Njoroge, Liezl Gibhard, Gareth Girling, Kathryn J Wicht, Marcus C S Lee, Sergio Wittlin, Diogo Rodrigo de Magalhães Moreira, Lyn-Marié Birkholtz, Kelly Chibale
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole. ACS medicinal chemistry letters 15 (4) (2024)
David E Heppner, Simone V Bigi-Botterill, Andrew P Riley, Kelly Chibale, Dennis C Liotta
Structural Biology in Drug Discovery and Development: Call for Papers. Journal of medicinal chemistry (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
John G Woodland, Kelly Chibale
Tips for Getting Your Manuscript Accepted into ACS Medicinal Chemistry Letters . ACS medicinal chemistry letters 15 (3) (2024)
Savannah J Watson, Mariëtte E van der Watt, Anjo Theron, Janette Reader, Sizwe Tshabalala, Erica Erlank, Lizette L Koekemoer, Mariska Naude, Marianna Stampolaki, Feyisola Adewole, Katie Sadowska, Pilar Pérez-Lozano, Andreea L Turcu, Santiago Vázquez, Jihee Ko, Ben Mazurek, Davinder Singh, Satish R Malwal, Mathew Njoroge, Kelly Chibale, Oluseye K Onajole, Antonios D Kolocouris, Eric Oldfield, Lyn-Marié Birkholtz
The Tuberculosis Drug Candidate SQ109 and Its Analogs Have Multistage Activity against Plasmodium falciparum . ACS infectious diseases (2024)
Jessica A Collins, Gregory S Basarab, Kelly Chibale, Neil Osheroff
Interactions between Zoliflodacin and Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS infectious diseases (2024)
John G Woodland, Kelly Chibale
Tips for Getting Your Manuscript Accepted into ACS Medicinal Chemistry Letters . ACS medicinal chemistry letters 15 (3) (2024)
David E Heppner, Simone V Bigi-Botterill, Andrew P Riley, Kelly Chibale, Dennis C Liotta
Structural Biology in Drug Discovery and Development: Call for Papers. Journal of medicinal chemistry 67 (15) (2024)
Flavio da Silva Emery, Kelly Chibale
Forging a Future Free from Neglected Tropical Diseases. ACS medicinal chemistry letters 15 (3) (2024)
Flavio da Silva Emery, Kelly Chibale
Forging a Future Free from Neglected Tropical Diseases. ACS medicinal chemistry letters 15 (3) (2024)
Jason Hlozek, Kelly Chibale, John G Woodland
Ongoing Implementation and Prospective Validation of Artificial Intelligence/Machine Learning Tools at an African Drug Discovery Center. ACS medicinal chemistry letters 15 (7) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry (2024)
Dickson Mambwe, Dina Coertzen, Meta Leshabane, Mwila Mulubwa, Mathew Njoroge, Liezl Gibhard, Gareth Girling, Kathryn J Wicht, Marcus C S Lee, Sergio Wittlin, Diogo Rodrigo de Magalhães Moreira, Lyn-Marié Birkholtz, Kelly Chibale
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole. ACS medicinal chemistry letters 15 (4) (2024)
Jessica A Collins, Gregory S Basarab, Kelly Chibale, Neil Osheroff
Interactions between Zoliflodacin and Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS infectious diseases 10 (8) (2024)
Jessica A Collins, Gregory S Basarab, Kelly Chibale, Neil Osheroff
Interactions between Zoliflodacin and Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS infectious diseases 10 (8) (2024)
Jessica A Collins, Gregory S Basarab, Kelly Chibale, Neil Osheroff
Interactions between Zoliflodacin and Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS infectious diseases 10 (8) (2024)
David E Heppner, Simone V Bigi-Botterill, Andrew P Riley, Kelly Chibale, Dennis C Liotta
Structural Biology in Drug Discovery and Development: Call for Papers. Journal of medicinal chemistry (2024)
John G Woodland, Gregory S Basarab, Koketso Mogwera, Susan Winks, Kelly Chibale
The 2022 H3D Symposium: Celebrating over a Decade of African-Led Infectious Disease Drug Discovery to Enhance Global Health. ACS infectious diseases (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. ACS infectious diseases 10 (1) (2023)
John G Woodland, Gregory S Basarab, Koketso Mogwera, Susan Winks, Kelly Chibale
The 2022 H3D Symposium: Celebrating over a Decade of African-Led Infectious Disease Drug Discovery to Enhance Global Health. ACS infectious diseases 9 (3) (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. Journal of medicinal chemistry 67 (1) (2023)
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J Wicht, Lubbe Wiesner, Timothy J Egan, Kelly Chibale
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum , and Synergize with Clinical Antimalarials. ACS infectious diseases 9 (3) (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. Journal of medicinal chemistry 67 (1) (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. ACS infectious diseases (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. Journal of medicinal chemistry (2023)
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J Wicht, Lubbe Wiesner, Timothy J Egan, Kelly Chibale
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum , and Synergize with Clinical Antimalarials. ACS infectious diseases 9 (3) (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. Journal of medicinal chemistry 67 (1) (2023)
Jo Ann W Byl, Rudolf Mueller, Benjamin D Bax, Gregory S Basarab, Kelly Chibale, Neil Osheroff
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase. ACS infectious diseases 9 (3) (2023)
Jo Ann W Byl, Rudolf Mueller, Benjamin D Bax, Gregory S Basarab, Kelly Chibale, Neil Osheroff
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase. ACS infectious diseases 9 (3) (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. ACS infectious diseases 10 (1) (2023)
Diego González Cabrera, Dennis A Smith, Gregory S Basarab, James Duffy, Thomas Spangenberg, Kelly Chibale
Anti-infectives Developed as Racemic Drugs in the 21st Century: Norm or Exception? ACS medicinal chemistry letters 14 (7) (2023)
Jo Ann W Byl, Rudolf Mueller, Benjamin D Bax, Gregory S Basarab, Kelly Chibale, Neil Osheroff
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase. ACS infectious diseases 9 (3) (2023)
Jo Ann W Byl, Rudolf Mueller, Benjamin D Bax, Gregory S Basarab, Kelly Chibale, Neil Osheroff
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase. ACS infectious diseases 9 (3) (2023)
Kaustuv Sanyal, Jayanta Haldar, Dennis C Liotta, Kelly Chibale
Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery. ACS infectious diseases 10 (1) (2023)
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J Wicht, Lubbe Wiesner, Timothy J Egan, Kelly Chibale
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum , and Synergize with Clinical Antimalarials. ACS infectious diseases (2023)
John G Woodland, Gregory S Basarab, Koketso Mogwera, Susan Winks, Kelly Chibale
The 2022 H3D Symposium: Celebrating over a Decade of African-Led Infectious Disease Drug Discovery to Enhance Global Health. ACS infectious diseases 9 (3) (2023)
Jo Ann W Byl, Rudolf Mueller, Benjamin D Bax, Gregory S Basarab, Kelly Chibale, Neil Osheroff
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase. ACS infectious diseases (2023)
Jo Ann W Byl, Rudolf Mueller, Benjamin D Bax, Gregory S Basarab, Kelly Chibale, Neil Osheroff
A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase. ACS infectious diseases 9 (3) (2023)
Henrietta D Attram, Constance Mawunyo Korkor, Dale Taylor, Mathew Njoroge, Kelly Chibale
Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies. ACS infectious diseases (2023)
Preshendren Govender, Rudolf Müller, Kawaljit Singh, Virsinha Reddy, Charles J Eyermann, Stephen Fienberg, Sandeep R Ghorpade, Lizbé Koekemoer, Alissa Myrick, Dirk Schnappinger, Curtis Engelhart, Jaclynn Meshanni, Jo Ann W Byl, Neil Osheroff, Vinayak Singh, Kelly Chibale, Gregory S Basarab
Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity. Journal of medicinal chemistry 65 (9) (2022)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry 65 (24) (2022)
Vinayak Singh, Anna E Grzegorzewicz, Stephen Fienberg, Rudolf Müller, Lutete Peguy Khonde, Olalla Sanz, Salvatore Alfonso, Beatriz Urones, Gerard Drewes, Marcus Bantscheff, Sonja Ghidelli-Disse, Thomas R Ioerger, Bhanupriya Angala, Jiuyu Liu, Richard E Lee, James C Sacchettini, Inna V Krieger, Mary Jackson, Kelly Chibale, Sandeep R Ghorpade
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis . ACS infectious diseases 8 (11) (2022)
Caroline C Sousa, Godwin Akpeko Dziwornu, Helenita C Quadros, João Honorato de Araujo-Neto, Kelly Chibale, Diogo Rodrigo de Magalhães Moreira
Antimalarial Pyrido[1,2- a ]benzimidazoles Exert Strong Parasiticidal Effects by Achieving High Cellular Uptake and Suppressing Heme Detoxification. ACS infectious diseases 8 (8) (2022)
Lauren B Arendse, Gyles E Cozier, Charles J Eyermann, Gregory S Basarab, Sylva L Schwager, Kelly Chibale, K Ravi Acharya, Edward D Sturrock
Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. Journal of medicinal chemistry 65 (4) (2022)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry 65 (24) (2022)
Nicole C Cardoso, Kelly Chibale, Vinayak Singh
Implications of Mycobacterium tuberculosis Metabolic Adaptability on Drug Discovery and Development. ACS infectious diseases 8 (3) (2022)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry 65 (24) (2022)
Dickson Mambwe, Constance Mawunyo Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo de Magalhães Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J Egan, Kelly Chibale
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model. Journal of medicinal chemistry (2022)
Vinayak Singh, Dickson Mambwe, Constance Mawunyo Korkor, Kelly Chibale
Innovation Experiences from Africa-Led Drug Discovery at the Holistic Drug Discovery and Development (H3D) Centre. ACS medicinal chemistry letters 13 (8) (2022)
Dorothy Semenya, Meir Touitou, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Luca Pisano, Vinayak Singh, Kelly Chibale, Georg Bano, Anita Toscani, Fabrizio Manetti, Beatrice Gianibbi, Daniele Castagnolo
Structural Rigidification of N -Aryl-pyrroles into Indoles Active against Intracellular and Drug-Resistant Mycobacteria. ACS medicinal chemistry letters 13 (1) (2021)
Godwin Akpeko Dziwornu, Dina Coertzen, Meta Leshabane, Constance Mawunyo Korkor, Cleavon K Cloete, Mathew Njoroge, Liezl Gibhard, Nina Lawrence, Janette Reader, Mariëtte van der Watt, Sergio Wittlin, Lyn-Marié Birkholtz, Kelly Chibale
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies. Journal of medicinal chemistry 64 (8) (2021)
Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B Simelane, Dale Taylor, Christel Brunschwig, Nina Lawrence, Dirk Schnappinger, Curtis A Engelhart, Anuradha Kumar, Tanya Parish, Qin Su, Timothy G Myers, Helena I M Boshoff, Clifton E Barry, Frederick A Sirgel, Paul D van Helden, Kirsteen I Buchanan, Tracy Bayliss, Simon R Green, Peter C Ray, Paul G Wyatt, Gregory S Basarab, Charles J Eyermann, Kelly Chibale, Sandeep R Ghorpade
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies. Journal of medicinal chemistry 64 (1) (2021)
Meta Leshabane, Godwin Akpeko Dziwornu, Dina Coertzen, Janette Reader, Phanankosi Moyo, Mariëtte van der Watt, Kelly Chisanga, Consolata Nsanzubuhoro, Richard Ferger, Erica Erlank, Nelius Venter, Lizette Koekemoer, Kelly Chibale, Lyn-Marié Birkholtz
Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites. ACS infectious diseases 7 (7) (2021)
Dennis C Liotta, James C Barrow, Kelly Chibale, Maria Laura Bolognesi, Stuart J Conway, William Alexander Denny, Ke Ding, Stefan A Laufer, Luhua Lai, Hong Liu, Nouri Neamati, Takayoshi Suzuki, Nicholas A Meanwell, Wendy B Young
Simplifying Submission Requirements for the Journal of Medicinal Chemistry. Journal of medicinal chemistry 64 (12) (2021)
Dickson Mambwe, Malkeet Kumar, Richard Ferger, Dale Taylor, Mathew Njoroge, Dina Coertzen, Janette Reader, Mariëtte van der Watt, Lyn-Marie Birkholtz, Kelly Chibale
Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against Plasmodium falciparum In Vitro. ACS medicinal chemistry letters 12 (8) (2021)
Vinayak Singh, Godwin Akpeko Dziwornu, Amanda Mabhula, Kelly Chibale
Rv0684/fusA1, an Essential Gene, Is the Target of Fusidic Acid and Its Derivatives in Mycobacterium tuberculosis. ACS infectious diseases 7 (8) (2021)
Lutete Peguy Khonde, Rudolf Müller, Grant A Boyle, Virsinha Reddy, Aloysius T Nchinda, Charles J Eyermann, Stephen Fienberg, Vinayak Singh, Alissa Myrick, Efrem Abay, Mathew Njoroge, Nina Lawrence, Qin Su, Timothy G Myers, Helena I M Boshoff, Clifton E Barry, Frederick A Sirgel, Paul D van Helden, Lisa M Massoudi, Gregory T Robertson, Anne J Lenaerts, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis. Journal of medicinal chemistry 64 (17) (2021)
Renier van der Westhuyzen, Amanda Mabhula, Paul M Njaria, Rudolf Müller, Denis Ngumbu Muhunga, Dale Taylor, Nina Lawrence, Mathew Njoroge, Christel Brunschwig, Atica Moosa, Vinayak Singh, Srinivasa P S Rao, Ujjini H Manjunatha, Paul W Smith, Digby F Warner, Leslie J Street, Kelly Chibale
Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure-Activity Relationship, Metabolism, and Biology Triaging. Journal of medicinal chemistry 64 (13) (2021)
Lauren B Arendse, Susan Wyllie, Kelly Chibale, Ian H Gilbert
Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities. ACS infectious diseases 7 (3) (2021)
Claire Le Manach, Jean Dam, John G Woodland, Gurminder Kaur, Lutete P Khonde, Christel Brunschwig, Mathew Njoroge, Kathryn J Wicht, André Horatscheck, Tanya Paquet, Grant A Boyle, Liezl Gibhard, Dale Taylor, Nina Lawrence, Tomas Yeo, Sachel Mok, Richard T Eastman, Dorjbal Dorjsuren, Daniel C Talley, Hui Guo, Anton Simeonov, Janette Reader, Mariëtte van der Watt, Erica Erlank, Nelius Venter, Jacek W Zawada, Ayesha Aswat, Luisa Nardini, Theresa L Coetzer, Sonja B Lauterbach, Belinda C Bezuidenhout, Anjo Theron, Dalu Mancama, Lizette L Koekemoer, Lyn-Marie Birkholtz, Sergio Wittlin, Michael Delves, Sabine Ottilie, Elizabeth A Winzeler, Thomas W von Geldern, Dennis Smith, David A Fidock, Leslie J Street, Gregory S Basarab, James Duffy, Kelly Chibale
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. Journal of medicinal chemistry 64 (4) (2021)
Kelly Chibale, Kathryn J Wicht, John G Woodland
Medicinal Chemistry Out of Africa. Journal of medicinal chemistry 64 (15) (2021)
Jandeli Niemand, Riëtte van Biljon, Mariëtte van der Watt, Ashleigh van Heerden, Janette Reader, Roelof van Wyk, Lindsey Orchard, Kelly Chibale, Manuel Llinás, Lyn-Marié Birkholtz
Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS infectious diseases 7 (10) (2021)
Hector Newman, Alen Krajnc, Dom Bellini, Charles J Eyermann, Grant A Boyle, Neil G Paterson, Katherine E McAuley, Robert Lesniak, Mukesh Gangar, Frank von Delft, Jürgen Brem, Kelly Chibale, Christopher J Schofield, Christopher G Dowson
High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes. Journal of medicinal chemistry 64 (15) (2021)
Vinayak Singh, Kelly Chibale
Strategies to Combat Multi-Drug Resistance in Tuberculosis. Accounts of chemical research 54 (10) (2021)
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C de Sousa, John Okombo, Keletso Maepa, Timothy J Egan, Lyn-Marie Birkholtz, Gregory S Basarab, Sergio Wittlin, Paul V Fish, Leslie J Street, James Duffy, Kelly Chibale
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model". Journal of medicinal chemistry 64 (3) (2021)
Nathaniel G Jones, Kelly Chibale, Felix Calderon
Special Issue on Epigenetic Modulation Approaches in Infectious Diseases. ACS infectious diseases 6 (11) (2020)
Peter Mubanga Cheuka, Godwin Dziwornu, John Okombo, Kelly Chibale
Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present). Journal of medicinal chemistry 63 (9) (2020)
Stephen Fienberg, Charles J Eyermann, Lauren B Arendse, Gregory S Basarab, Jacob A McPhail, John E Burke, Kelly Chibale
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors. ACS infectious diseases 6 (11) (2020)
Jessica N Akester, Paul Njaria, Aloysius Nchinda, Claire Le Manach, Alissa Myrick, Vinayak Singh, Nina Lawrence, Mathew Njoroge, Dale Taylor, Atica Moosa, Anthony J Smith, Elizabeth J Brooks, Anne J Lenaerts, Gregory T Robertson, Thomas R Ioerger, Rudolf Mueller, Kelly Chibale
Synthesis, Structure-Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity. ACS infectious diseases 6 (7) (2020)
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Lutete Peguy Khonde, Jean Dam, Kailash Pawar, Dale Taylor, Nina Lawrence, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Janette Reader, Mariëtte van der Watt, Kathryn Wicht, Ana Carolina C de Sousa, John Okombo, Keletso Maepa, Timothy J Egan, Lyn-Marie Birkholtz, Gregory S Basarab, Sergio Wittlin, Paul V Fish, Leslie J Street, James Duffy, Kelly Chibale
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model. Journal of medicinal chemistry 63 (21) (2020)
Alexandra Probst, Kelly Chisanga, Godwin Akpeko Dziwornu, Cécile Haeberli, Jennifer Keiser, Kelly Chibale
Expanding the Activity Profile of Pyrido[1,2-a]benzimidazoles: Synthesis and Evaluation of Novel N1-1-Phenylethanamine Derivatives against Schistosoma mansoni. ACS infectious diseases 7 (5) (2020)
Peter Mubanga Cheuka, Luyanda Centani, Lauren B Arendse, Stephen Fienberg, Lynn Wambua, Shoneeze S Renga, Godwin Akpeko Dziwornu, Malkeet Kumar, Nina Lawrence, Dale Taylor, Sergio Wittlin, Dina Coertzen, Janette Reader, Mariette van der Watt, Lyn-Marie Birkholtz, Kelly Chibale
New Amidated 3,6-Diphenylated Imidazopyridazines with Potent Antiplasmodium Activity Are Dual Inhibitors of Plasmodium Phosphatidylinositol-4-kinase and cGMP-Dependent Protein Kinase. ACS infectious diseases 7 (1) (2020)
Natasha Strydom, Gurminder Kaur, Godwin Akpeko Dziwornu, John Okombo, Lubbe Wiesner, Kelly Chibale
Pharmacokinetics and Organ Distribution of C-3 Alkyl Esters as Potential Antimycobacterial Prodrugs of Fusidic Acid. ACS infectious diseases 6 (3) (2020)
Clinton G L Veale, Dustin Laming, Tarryn Swart, Kelly Chibale, Heinrich C Hoppe
Exploring the Antiplasmodial 2-Aminopyridines as Potential Antitrypanosomal Agents. ChemMedChem 14 (24) (2019)
Godfrey Mayoka, Jennifer Keiser, Cécile Häberli, Kelly Chibale
Structure-Activity Relationship and in Vitro Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Studies of N-aryl 3-Trifluoromethyl Pyrido[1,2- a]benzimidazoles That Are Efficacious in a Mouse Model of Schistosomiasis. ACS infectious diseases 5 (3) (2019)
Mathew Njoroge, Gurminder Kaur, Marlene Espinoza-Moraga, Antonina Wasuna, Godwin Akpeko Dziwornu, Ronnett Seldon, Dale Taylor, John Okombo, Digby F Warner, Kelly Chibale
Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture. ACS infectious diseases 5 (9) (2019)
Malkeet Kumar, John Okombo, Dickson Mambwe, Dale Taylor, Nina Lawrence, Janette Reader, Mariëtte van der Watt, Diana Fontinha, Margarida Sanches-Vaz, Belinda C Bezuidenhout, Sonja B Lauterbach, Dale Liebenberg, Lyn-Marie Birkholtz, Theresa L Coetzer, Miguel Prudêncio, Timothy J Egan, Sergio Wittlin, Kelly Chibale
Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action. ACS infectious diseases 5 (2) (2019)
John Okombo, Christel Brunschwig, Kawaljit Singh, Godwin Akpeko Dziwornu, Linley Barnard, Mathew Njoroge, Sergio Wittlin, Kelly Chibale
Antimalarial Pyrido[1,2- a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies. ACS infectious diseases 5 (3) (2019)
Godfrey Mayoka, Mathew Njoroge, John Okombo, Liezl Gibhard, Margarida Sanches-Vaz, Diana Fontinha, Lyn-Marie Birkholtz, Janette Reader, Mariëtte van der Watt, Theresa L Coetzer, Sonja Lauterbach, Alisje Churchyard, Belinda Bezuidenhout, Timothy J Egan, Clive Yeates, Sergio Wittlin, Miguel Prudêncio, Kelly Chibale
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria. Journal of medicinal chemistry 62 (2) (2018)
Diego González Cabrera, André Horatscheck, Colin R Wilson, Greg Basarab, Charles J Eyermann, Kelly Chibale
Plasmodial Kinase Inhibitors: License to Cure? Journal of medicinal chemistry 61 (18) (2018)
Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Diego Gonzàlez Cabrera, Kathryn J Wicht, Christel Brunschwig, Mathew Njoroge, Efrem Abay, Dale Taylor, Nina Lawrence, Sergio Wittlin, María-Belén Jiménez-Díaz, María Santos Martínez, Santiago Ferrer, Iñigo Angulo-Barturen, Maria Jose Lafuente-Monasterio, James Duffy, Jeremy Burrows, Leslie J Street, Kelly Chibale
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria. Journal of medicinal chemistry 61 (9) (2018)
Nishanth Kandepedu, Diego Gonzàlez Cabrera, Srinivas Eedubilli, Dale Taylor, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Tanya Paquet, Charles J Eyermann, Thomas Spangenberg, Gregory S Basarab, Leslie J Street, Kelly Chibale
Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria. Journal of medicinal chemistry 61 (13) (2018)
Dinakaran Murugesan, Peter C Ray, Tracy Bayliss, Gareth A Prosser, Justin R Harrison, Kirsteen Green, Candice Soares de Melo, Tzu-Shean Feng, Leslie J Street, Kelly Chibale, Digby F Warner, Valerie Mizrahi, Ola Epemolu, Paul Scullion, Lucy Ellis, Jennifer Riley, Yoko Shishikura, Liam Ferguson, Maria Osuna-Cabello, Kevin D Read, Simon R Green, Dirk A Lamprecht, Peter M Finin, Adrie J C Steyn, Thomas R Ioerger, Jim Sacchettini, Kyu Y Rhee, Kriti Arora, Clifton Earl Barry, Paul G Wyatt, Helena I M Boshoff
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. ACS infectious diseases 4 (6) (2018)
Claire Le Manach, Tanya Paquet, Kathryn Wicht, Aloysius T Nchinda, Christel Brunschwig, Mathew Njoroge, Liezl Gibhard, Dale Taylor, Nina Lawrence, Sergio Wittlin, Charles J Eyermann, Gregory S Basarab, James Duffy, Paul V Fish, Leslie J Street, Kelly Chibale
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains. Journal of medicinal chemistry 61 (20) (2018)
Gurminder Kaur, Elumalai Pavadai, Sergio Wittlin, Kelly Chibale
3D-QSAR Modeling and Synthesis of New Fusidic Acid Derivatives as Antiplasmodial Agents. Journal of chemical information and modeling 58 (8) (2018)
Mukesh C Joshi, John Okombo, Samkele Nsumiwa, Jeffrey Ndove, Dale Taylor, Lubbe Wiesner, Roger Hunter, Kelly Chibale, Timothy J Egan
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice. Journal of medicinal chemistry 60 (24) (2017)
Colin R Wilson, Richard K Gessner, Atica Moosa, Ronnett Seldon, Digby F Warner, Valerie Mizrahi, Candice Soares de Melo, Sandile B Simelane, Aloysius Nchinda, Efrem Abay, Dale Taylor, Mathew Njoroge, Christel Brunschwig, Nina Lawrence, Helena I M Boshoff, Clifton E Barry, Frederick A Sirgel, Paul van Helden, C John Harris, Richard Gordon, Sonja Ghidelli-Disse, Hannah Pflaumer, Markus Boesche, Gerard Drewes, Olalla Sanz, Gracia Santos, Maria José Rebollo-Lopez, Beatriz Urones, Carolyn Selenski, Maria Jose Lafuente-Monasterio, Matthew Axtman, Joël Lelièvre, Lluis Ballell, Rudolf Mueller, Leslie J Street, Sandeep R Ghorpade, Kelly Chibale
Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies. Journal of medicinal chemistry 60 (24) (2017)
John Okombo, Kawaljit Singh, Godfrey Mayoka, Ferdinand Ndubi, Linley Barnard, Peter M Njogu, Mathew Njoroge, Liezl Gibhard, Christel Brunschwig, Mireille Vargas, Jennifer Keiser, Timothy J Egan, Kelly Chibale
Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation. ACS infectious diseases 3 (6) (2017)
John Okombo, Kelly Chibale
Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery. Accounts of chemical research 50 (7) (2017)
Stephen Fienberg, Gyles E Cozier, K Ravi Acharya, Kelly Chibale, Edward D Sturrock
The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme. Journal of medicinal chemistry 61 (1) (2017)
Kawaljit Singh, John Okombo, Christel Brunschwig, Ferdinand Ndubi, Linley Barnard, Chad Wilkinson, Peter M Njogu, Mathew Njoroge, Lizahn Laing, Marta Machado, Miguel Prudêncio, Janette Reader, Mariette Botha, Sindisiwe Nondaba, Lyn-Marie Birkholtz, Sonja Lauterbach, Alisje Churchyard, Theresa L Coetzer, Jeremy N Burrows, Clive Yeates, Paolo Denti, Lubbe Wiesner, Timothy J Egan, Sergio Wittlin, Kelly Chibale
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model. Journal of medicinal chemistry 60 (4) (2017)
Rajni K Sharma, Marlene Espinoza-Moraga, Horacio Poblete, Ross G Douglas, Edward D Sturrock, Julio Caballero, Kelly Chibale
The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. Journal of chemical information and modeling 56 (12) (2016)