Tomohisa Kuzuyama

ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 27

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

Biochemistry

ACS chemical biology

The University of Tokyo

This page only lists publications with an associated author ORCID identifier.

Affiliation History

The University of Tokyo

Japan

Professor

Publications

Ryuhei Nagata, Makoto Nishiyama, Tomohisa Kuzuyama
Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase. Biochemistry (2023)
Genki Hibi, Taro Shiraishi, Tatsuki Umemura, Kenji Nemoto, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama
Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin. Nature communications 14 (1) (2023)
Tomohiro Noguchi, Shota Isogai, Tohru Terada, Makoto Nishiyama, Tomohisa Kuzuyama
Cryptic Oxidative Transamination of Hydroxynaphthoquinone in Natural Product Biosynthesis. Journal of the American Chemical Society 144 (12) (2022)
Ryuhei Nagata, Hironori Suemune, Masaya Kobayashi, Tetsuro Shinada, Teppei Kawahara, Makoto Nishiyama, Tomoya Hino, Yusuke Sato, Tomohisa Kuzuyama, Shingo Nagano
Structural Basis for the Prenylation Reaction of Carbazole-Containing Natural Products Catalyzed by Squalene Synthase-Like Enzymes. Angewandte Chemie (International ed. in English) 61 (20) (2022)
Yuxun Zhu, Taro Shiraishi, Jianwen Lin, Keito Inaba, Atsuro Ito, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama
Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C-C Bond. Journal of the American Chemical Society 144 (37) (2022)
Xiaofei Shao, Chang Zheng, Peng Xu, Taro Shiraishi, Tomohisa Kuzuyama, Antonio Molinaro, Alba Silipo, Biao Yu
Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A-94964. Angewandte Chemie (International ed. in English) 61 (14) (2022)
Taro Shiraishi, Jiaqi Xia, Teruhito Kato, Tomohisa Kuzuyama
Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation. The Journal of antibiotics 74 (11) (2021)
Sumire Kurosawa, Kenichi Matsuda, Fumihito Hasebe, Taro Shiraishi, Kazuo Shin-Ya, Tomohisa Kuzuyama, Makoto Nishiyama
Guanidyl modification of the 1-azabicyclo[3.1.0]hexane ring in ficellomycin essential for its biological activity. Organic & biomolecular chemistry 18 (27) (2021)
Jie Zhang, Satoshi Yuzawa, Wei Li Thong, Tetsuro Shinada, Makoto Nishiyama, Tomohisa Kuzuyama
Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis. Journal of the American Chemical Society 143 (7) (2021)
Kei Sakaki, Keita Ohishi, Tetsu Shimizu, Ikki Kobayashi, Naoki Mori, Kenichi Matsuda, Takeo Tomita, Hidenori Watanabe, Kan Tanaka, Tomohisa Kuzuyama, Makoto Nishiyama
A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria. Nature chemical biology 16 (4) (2020)
Masaya Kobayashi, Tomohisa Kuzuyama
Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes. Biomolecules 10 (8) (2020)
Tomohiro Suzuki, Takeo Tomita, Kenta Hirayama, Michio Suzuki, Tomohisa Kuzuyama, Makoto Nishiyama
Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius. The FEBS journal 288 (6) (2020)
Masaya Kobayashi, Takeo Tomita, Teppei Kawahara, Makoto Nishiyama, Tomohisa Kuzuyama
An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces. Angewandte Chemie (International ed. in English) 58 (38) (2019)
Keiichi Murai, Lukas Lauterbach, Kazuya Teramoto, Zhiyang Quan, Lena Barra, Tsuyoshi Yamamoto, Kenichi Nonaka, Kazuro Shiomi, Makoto Nishiyama, Tomohisa Kuzuyama, Jeroen S Dickschat
An Unusual Skeletal Rearrangement in the Biosynthesis of the Sesquiterpene Trichobrasilenol from Trichoderma. Angewandte Chemie (International ed. in English) 58 (42) (2019)
Anthony J Romo, Taro Shiraishi, Hideo Ikeuchi, Geng-Min Lin, Yujie Geng, Yu-Hsuan Lee, Priscilla H Liem, Tianlu Ma, Yasushi Ogasawara, Teppei Kawahara, Makoto Nishiyama, Tomohisa Kuzuyama, Hung-Wen Liu
The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics. Journal of the American Chemical Society 141 (36) (2019)
Kei Kudo, Hanae Koiwai, Noritaka Kagaya, Makoto Nishiyama, Tomohisa Kuzuyama, Teppei Kawahara, Haruo Ikeda
Comprehensive Derivatization of Thioviridamides by Heterologous Expression. ACS chemical biology 14 (6) (2019)
Taro Shiraishi, Tomohisa Kuzuyama
Recent advances in the biosynthesis of nucleoside antibiotics. The Journal of antibiotics 72 (12) (2019)
Wei Li Thong, Kazuo Shin-Ya, Makoto Nishiyama, Tomohisa Kuzuyama
Discovery of an Antibacterial Isoindolinone-Containing Tetracyclic Polyketide by Cryptic Gene Activation and Characterization of Its Biosynthetic Gene Cluster. ACS chemical biology 13 (9) (2018)
Masaya Kobayashi, Tomohisa Kuzuyama
Structural and Mechanistic Insight into Terpene Synthases that Catalyze the Irregular Non-Head-to-Tail Coupling of Prenyl Substrates. Chembiochem : a European journal of chemical biology 20 (1) (2018)
Shusuke Sato, Akimasa Miyanaga, Seung-Young Kim, Tomohisa Kuzuyama, Fumitaka Kudo, Tadashi Eguchi
Biochemical and Structural Analysis of FomD That Catalyzes the Hydrolysis of Cytidylyl ( S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis. Biochemistry 57 (32) (2018)
Shusuke Sato, Fumitaka Kudo, Tomohisa Kuzuyama, Friedrich Hammerschmidt, Tadashi Eguchi
C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration. Biochemistry 57 (33) (2018)
Kenichi Matsuda, Takeo Tomita, Kazuo Shin-Ya, Toshiyuki Wakimoto, Tomohisa Kuzuyama, Makoto Nishiyama
Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria. Journal of the American Chemical Society 140 (29) (2018)
Takeo Tomita, Masaya Kobayashi, Yuma Karita, Yoko Yasuno, Tetsuro Shinada, Makoto Nishiyama, Tomohisa Kuzuyama
Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization. Angewandte Chemie (International ed. in English) 56 (47) (2017)
Kei Kudo, Taro Ozaki, Kazuo Shin-Ya, Makoto Nishiyama, Tomohisa Kuzuyama
Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. Journal of the American Chemical Society 139 (20) (2017)
Su-Hee Cho, Seung-Young Kim, Takeo Tomita, Taro Shiraishi, Jin-Soo Park, Shusuke Sato, Fumitaka Kudo, Tadashi Eguchi, Nobutaka Funa, Makoto Nishiyama, Tomohisa Kuzuyama
Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme. ACS chemical biology 12 (8) (2017)
Shusuke Sato, Fumitaka Kudo, Seung-Young Kim, Tomohisa Kuzuyama, Tadashi Eguchi
Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis. Biochemistry 56 (28) (2017)
Takeo Tomita, Seung-Young Kim, Kazuya Teramoto, Ayuko Meguro, Taro Ozaki, Ayako Yoshida, Yudai Motoyoshi, Naoki Mori, Ken Ishigami, Hidenori Watanabe, Makoto Nishiyama, Tomohisa Kuzuyama
Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol. ACS chemical biology 12 (6) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Tomohisa Kuzuyama