Hung-Wen Liu

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 50

Top Topics

Structural Basis

Binding Protein

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Shusuke Sato, Po-Hsun Fan, Yu-Cheng Yeh, Hung-Wen Liu
Complete In Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step. Journal of the American Chemical Society 146 (14) (2024)
Ziyang Zheng, Jon Clardy, Hung-Wen Liu
Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin. Journal of the American Chemical Society (2024)
Ziyang Zheng, Jon Clardy, Hung-Wen Liu
Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin. Journal of the American Chemical Society 146 (30) (2024)
Shusuke Sato, Po-Hsun Fan, Yu-Cheng Yeh, Hung-Wen Liu
Complete In Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step. Journal of the American Chemical Society 146 (14) (2024)
Shusuke Sato, Po-Hsun Fan, Yu-Cheng Yeh, Hung-Wen Liu
Complete In Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step. Journal of the American Chemical Society 146 (14) (2024)
Shusuke Sato, Po-Hsun Fan, Yu-Cheng Yeh, Hung-Wen Liu
Complete In Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step. Journal of the American Chemical Society (2024)
Ziyang Zheng, Jon Clardy, Hung-Wen Liu
Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin. Journal of the American Chemical Society 146 (30) (2024)
Shusuke Sato, Po-Hsun Fan, Yu-Cheng Yeh, Hung-Wen Liu
Complete In Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step. Journal of the American Chemical Society 146 (14) (2024)
Po-Hsun Fan, Shusuke Sato, Yu-Cheng Yeh, Hung-Wen Liu
Biosynthetic Origin of the Octose Core and Its Mechanism of Assembly during Apramycin Biosynthesis. Journal of the American Chemical Society (2023)
Yu-Hsuan Lee, Yu-Cheng Yeh, Po-Hsun Fan, Aoshu Zhong, Mark W Ruszczycky, Hung-Wen Liu
Changing Fates of the Substrate Radicals Generated in the Active Sites of the B 12 -Dependent Radical SAM Enzymes OxsB and AlsB. Journal of the American Chemical Society 145 (6) (2023)
Yu-Hsuan Lee, Yu-Cheng Yeh, Po-Hsun Fan, Aoshu Zhong, Mark W Ruszczycky, Hung-Wen Liu
Changing Fates of the Substrate Radicals Generated in the Active Sites of the B 12 -Dependent Radical SAM Enzymes OxsB and AlsB. Journal of the American Chemical Society 145 (6) (2023)
Yu-Hsuan Lee, Daan Ren, Byungsun Jeon, Hung-Wen Liu
S -Adenosylmethionine: more than just a methyl donor. Natural product reports (2023)
Yu-Hsuan Lee, Yu-Cheng Yeh, Po-Hsun Fan, Aoshu Zhong, Mark W Ruszczycky, Hung-Wen Liu
Changing Fates of the Substrate Radicals Generated in the Active Sites of the B 12 -Dependent Radical SAM Enzymes OxsB and AlsB. Journal of the American Chemical Society 145 (6) (2023)
Yu-Hsuan Lee, Yu-Cheng Yeh, Po-Hsun Fan, Aoshu Zhong, Mark W Ruszczycky, Hung-Wen Liu
Changing Fates of the Substrate Radicals Generated in the Active Sites of the B 12 -Dependent Radical SAM Enzymes OxsB and AlsB. Journal of the American Chemical Society (2023)
Yu-Hsuan Lee, Yu-Cheng Yeh, Po-Hsun Fan, Aoshu Zhong, Mark W Ruszczycky, Hung-Wen Liu
Changing Fates of the Substrate Radicals Generated in the Active Sites of the B 12 -Dependent Radical SAM Enzymes OxsB and AlsB. Journal of the American Chemical Society 145 (6) (2023)
Jiawei Zhang, Xueli Hou, Zhang Chen, Yeonjin Ko, Mark W Ruszczycky, Yutian Chen, Jiahai Zhou, Hung-Wen Liu
Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. Journal of the American Chemical Society 144 (22) (2022)
Po-Hsun Fan, Yujie Geng, Anthony J Romo, Aoshu Zhong, Jiawei Zhang, Yu-Cheng Yeh, Yu-Hsuan Lee, Hung-Wen Liu
Two Radical SAM Enzymes Are Necessary and Sufficient for the In Vitro Production of the Oxetane Nucleoside Antiviral Agent Albucidin. Angewandte Chemie (International ed. in English) 61 (42) (2022)
Bidhan Chandra De, Wenjun Zhang, Chunfang Yang, Attila Mándi, Chunshuai Huang, Liping Zhang, Wei Liu, Mark W Ruszczycky, Yiguang Zhu, Ming Ma, Ghader Bashiri, Tibor Kurtán, Hung-Wen Liu, Changsheng Zhang
Flavin-enabled reductive and oxidative epoxide ring opening reactions. Nature communications 13 (1) (2022)
Tzu-Yu Chen, Ziyang Zheng, Xuan Zhang, Jinfeng Chen, Lide Cha, Yijie Tang, Yisong Guo, Jiahai Zhou, Binju Wang, Hung-Wen Liu, Wei-Chen Chang
Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis. ACS catalysis 12 (4) (2022)
Daan Ren, Yu-Hsuan Lee, Shao-An Wang, Hung-Wen Liu
Characterization of the Oxazinomycin Biosynthetic Pathway Revealing the Key Role of a Nonheme Iron-Dependent Mono-oxygenase. Journal of the American Chemical Society 144 (24) (2022)
Yu-Hsuan Lee, Xueli Hou, Ridao Chen, Jianqiang Feng, Xiao Liu, Mark W Ruszczycky, Jin-Ming Gao, Binju Wang, Jiahai Zhou, Hung-Wen Liu
Radical S -Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S. Journal of the American Chemical Society 144 (10) (2022)
Zhang Chen, Shusuke Sato, Yujie Geng, Jiawei Zhang, Hung-Wen Liu
Identification of the Early Steps in Herbicidin Biosynthesis Reveals an Atypical Mechanism of C -Glycosylation. Journal of the American Chemical Society 144 (34) (2022)
Mark W Ruszczycky, Hung-Wen Liu
Distinguishing Concerted versus Stepwise Mechanisms Using Isotope Effects on Isotope Effects. Biochemistry 60 (46) (2021)
Ronald A Besandre, Zhang Chen, Ian Davis, Jiawei Zhang, Mark Walter Ruszczycky, Aimin Liu, Hung-Wen Liu
HygY Is a Twitch Radical SAM Epimerase with Latent Dehydrogenase Activity Revealed upon Mutation of a Single Cysteine Residue. Journal of the American Chemical Society 143 (37) (2021)
Aoshu Zhong, Yu-Hsuan Lee, Yung-Nan Liu, Hung-Wen Liu
Biosynthesis of Oxetanocin-A Includes a B12-Dependent Radical SAM Enzyme That Can Catalyze both Oxidative Ring Contraction and the Demethylation of SAM. Biochemistry 60 (7) (2021)
Daan Ren, Minje Kim, Shao-An Wang, Hung-Wen Liu
Identification of a Pyrrole Intermediate Which Undergoes C-Glycosidation and Autoxidation to Yield the Final Product in Showdomycin Biosynthesis. Angewandte Chemie (International ed. in English) 60 (31) (2021)
Sei-Hyun Choi, Byungsun Jeon, Namho Kim, Hsin-Hui Wu, Tzu-Ping Ko, Mark W Ruszczycky, Eta A Isiorho, Yung-Nan Liu, Adrian T Keatinge-Clay, Ming-Daw Tsai, Hung-Wen Liu
Evidence for an Enzyme-Catalyzed Rauhut-Currier Reaction during the Biosynthesis of Spinosyn A. Journal of the American Chemical Society 143 (48) (2021)
Yu-Cheng Yeh, Hak Joong Kim, Hung-Wen Liu
Mechanistic Investigation of 1,2-Diol Dehydration of Paromamine Catalyzed by the Radical S-Adenosyl-l-methionine Enzyme AprD4. Journal of the American Chemical Society 143 (13) (2021)
Daan Ren, Mark W Ruszczycky, Yeonjin Ko, Shao-An Wang, Yasushi Ogasawara, Minje Kim, Hung-Wen Liu
Characterization of the coformycin biosynthetic gene cluster in Streptomyces kaniharaensis. Proceedings of the National Academy of Sciences of the United States of America 117 (19) (2020)
Richiro Ushimaru, Zhang Chen, Houyuan Zhao, Po-Hsun Fan, Hung-Wen Liu
Identification of the Enzymes Mediating the Maturation of the Seryl-tRNA Synthetase Inhibitor SB-217452 during the Biosynthesis of Albomycins. Angewandte Chemie (International ed. in English) 59 (9) (2020)
Shao-An Wang, Chia-I Lin, Jiawei Zhang, Richiro Ushimaru, Eita Sasaki, Hung-Wen Liu
Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A. Proceedings of the National Academy of Sciences of the United States of America 117 (40) (2020)
Yeon Hee Ban, Myoung Chong Song, Jae-Yeon Hwang, Hea-Lyung Shin, Hak Joong Kim, Seung Kon Hong, Na Joon Lee, Je Won Park, Sun-Shin Cha, Hung-Wen Liu, Yeo Joon Yoon
Complete reconstitution of the diverse pathways of gentamicin B biosynthesis. Nature chemical biology 15 (3) (2019)
Richiro Ushimaru, Hung-Wen Liu
Biosynthetic Origin of the Atypical Stereochemistry in the Thioheptose Core of Albomycin Nucleoside Antibiotics. Journal of the American Chemical Society 141 (6) (2019)
Shao-An Wang, Yeonjin Ko, Jia Zeng, Yujie Geng, Daan Ren, Yasushi Ogasawara, Seema Irani, Yan Jessie Zhang, Hung-Wen Liu
Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis. Journal of the American Chemical Society 141 (15) (2019)
Anthony J Romo, Taro Shiraishi, Hideo Ikeuchi, Geng-Min Lin, Yujie Geng, Yu-Hsuan Lee, Priscilla H Liem, Tianlu Ma, Yasushi Ogasawara, Teppei Kawahara, Makoto Nishiyama, Tomohisa Kuzuyama, Hung-Wen Liu
The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics. Journal of the American Chemical Society 141 (36) (2019)
Daan Ren, Shao-An Wang, Yeonjin Ko, Yujie Geng, Yasushi Ogasawara, Hung-Wen Liu
Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin. Angewandte Chemie (International ed. in English) 58 (46) (2019)
Hai-Xue Pan, Zhang Chen, Tianfang Zeng, Wen-Bing Jin, Yujie Geng, Geng-Min Lin, Juan Zhao, Wei-Tao Li, Zijun Xiong, Sheng-Xiong Huang, Xin Zhai, Hung-Wen Liu, Gong-Li Tang
Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. Organic letters 21 (5) (2019)
Mark W Ruszczycky, Hung-Wen Liu
Measurement of Net Rate Constants from Enzyme Progress Curves without Curve Fitting. Biochemistry 58 (49) (2019)
Richiro Ushimaru, Mark W Ruszczycky, Wei-Chen Chang, Feng Yan, Yung-Nan Liu, Hung-Wen Liu
Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions. Journal of the American Chemical Society 140 (24) (2018)
Zhongyue Yang, Song Yang, Peiyuan Yu, Yanwei Li, Charles Doubleday, Jiyong Park, Ashay Patel, Byung-Sun Jeon, William K Russell, Hung-Wen Liu, David H Russell, Kendall N Houk
Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition. Proceedings of the National Academy of Sciences of the United States of America 115 (5) (2018)
Richiro Ushimaru, Mark W Ruszczycky, Hung-Wen Liu
Changes in Regioselectivity of H Atom Abstraction during the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase. Journal of the American Chemical Society 141 (2) (2018)
Jung-Kuei Chen, Wen-Ling Lin, Zhang Chen, Hung-Wen Liu
PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability. Proceedings of the National Academy of Sciences of the United States of America 115 (8) (2018)
Yeonjin Ko, Geng-Min Lin, Mark W Ruszczycky, Hung-Wen Liu
Mechanistic Implications of the Deamination of TDP-4-amino-4-deoxy-d-fucose Catalyzed by the Radical SAM Enzyme DesII. Biochemistry 57 (22) (2018)
Geng-Min Lin, Anthony J Romo, Priscilla H Liem, Zhang Chen, Hung-Wen Liu
Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic. Journal of the American Chemical Society 139 (46) (2017)
Chia-I Lin, Reid M McCarty, Hung-Wen Liu
The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems. Angewandte Chemie (International ed. in English) 56 (13) (2017)
Hak Joong Kim, Yung-Nan Liu, Reid M McCarty, Hung-Wen Liu
Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical S-Adenosyl-l-methionine Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration. Journal of the American Chemical Society 139 (45) (2017)
Byung-Sun Jeon, Mark W Ruszczycky, William K Russell, Geng-Min Lin, Namho Kim, Sei-Hyun Choi, Shao-An Wang, Yung-Nan Liu, John W Patrick, David H Russell, Hung-Wen Liu
Investigation of the mechanism of the SpnF-catalyzed [4+2]-cycloaddition reaction in the biosynthesis of spinosyn A. Proceedings of the National Academy of Sciences of the United States of America 114 (39) (2017)
Yeonjin Ko, Shao-An Wang, Yasushi Ogasawara, Mark W Ruszczycky, Hung-Wen Liu
Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A. Organic letters 19 (6) (2017)
Ronald Besandre, Hung-Wen Liu
Biochemical Basis of Vosevi, a New Treatment for Hepatitis CPublished as part of the Biochemistry series "Biochemistry to Bedside". Biochemistry 57 (5) (2017)
Hak Joong Kim, Jake LeVieux, Yu-Cheng Yeh, Hung-Wen Liu
C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and Its Reductase Partner AprD3. Angewandte Chemie (International ed. in English) 55 (11) (2016)