ACS medicinal chemistry letters

Keyphrases

Publications

volume 15, number 8, 2024

Allen F Brooks, Jason A Witek, Wade P Winton, Jenelle Stauff, Bradford Henderson, Peter J H Scott, Benjamin L Viglianti
3AcFNP-59 for Positron Emission Tomography Imaging of Cholesterol Trafficking and Utilization. ACS medicinal chemistry letters 15 (8) (2024)
Rachel Mata
Novel Imidazopyridine and Imidazopyridazine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases. ACS medicinal chemistry letters 15 (8) (2024)
Joshua W Powell, Chelsea A Mann, Paul D Toth, Sheri Nolan, Anja Steinert, Clarissa Ove, Justin T Seffernick, Daniel J Wozniak, Razieh Kebriaei, Steffen Lindert, Neil Osheroff, Jack C Yalowich, Mark J Mitton-Fry
Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS medicinal chemistry letters 15 (8) (2024)
Michael A Plotkin, Marc Labroli, Jeffrey W Schubert, Anthony Shaw, Kelly-Ann S Schlegel, Richard Berger, Andrew J Cooke, Robert P Hayes, Kira A Armacost, Keith Kinek, Paula Krosky, Christine Burlein, Shi Meng, Edward DiNunzio, Edward M Murray, Sony Agrawal, Maria Madeira, Amy Flattery, Huifang Yao, Andrew Leithead, William A Rose, Christopher Cox, David M Tellers, Philip M McKenna, Izzat T Raheem
Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships. ACS medicinal chemistry letters 15 (8) (2024)
Samantha A Kennelly, Jacob M Sawyer, Anne F Payne, Alexander T Ciota, Daniel A Harki
Development of 3'-Deoxy-3',4'-didehydro-nucleoside Prodrug Inhibitors of West Nile and Zika Viruses. ACS medicinal chemistry letters 15 (8) (2024)
Robert B Kargbo
Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors. ACS medicinal chemistry letters 15 (8) (2024)
Sjors van Klaveren, Mujtaba Hassan, Maria Håkansson, Richard E Johnsson, Jessica Larsson, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Tihomir Tomašič, Ulf J Nilsson
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket. ACS medicinal chemistry letters 15 (8) (2024)
Haojie Zuo, Yiming Ru, Xiuxiu Gao, Hui Chen, Yaoyao Yan, Xiaodong Ma, Xin Hua Liu, Yang Wang
Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity. ACS medicinal chemistry letters 15 (8) (2024)
Sabyasachi Mandal, Yelisetty Venkata Suseela, Sourav Samanta, Bertrand Vileno, Peter Faller, Thimmaiah Govindaraju
Fluorescent Peptides Sequester Redox Copper to Mitigate Oxidative Stress, Amyloid Toxicity, and Neuroinflammation. ACS medicinal chemistry letters 15 (8) (2024)
Rebecca E Moore, Stevan W Djuric
Future of Medicinal Chemistry Collection. ACS medicinal chemistry letters 15 (8) (2024)
Rachel Mata
Novel Glucagon-like Peptide 1 Receptor Agonists for Treating Type II Diabetes. ACS medicinal chemistry letters 15 (8) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)

volume 15, number 9, 2024

Margrate Anyanwu, Matteo Giannangeli, Xing-Xing Fan, Paolo Coghi, Giovanni Ribaudo, Alessandra Gianoncelli
9,10-Bis[(4-(2-hydroxyethyl)piperazine-1-yl)prop2-yne-1-yl]anthracene: G-Quadruplex Selectivity and Anticancer Activity. ACS medicinal chemistry letters 15 (9) (2024)
Manikandan M, Sushanta Chhatar, Saurabh Dey, Tushar Ranjan Panda, Sourav Chakraborty, Pritha Ray, Chinmoy Patra, Malay Patra
Analysis of Antiangiogenic Potential and Cell Death Mechanism of a Kinetically Inert Platinum Antitumor Agent. ACS medicinal chemistry letters 15 (9) (2024)
Gemma Turon, Edwin Tse, Xin Qiu, Matthew H Todd, Miquel Duran-Frigola
Open Source Code Contributions to Global Health: The Case of Antimalarial Drug Discovery. ACS medicinal chemistry letters 15 (9) (2024)
William F Tracy, Geraint H M Davies, Lei Jia, Ethan D Evans, Zhenghang Sun, Jennifer Buenviaje, Gody Khambatta, Shan Yu, Lihong Shi, Veerabahu Shanmugasundaram, Jesus Moreno, Emily C Cherney, Huw M L Davies
Asymmetric Dirhodium-Catalyzed Modification of Immunomodulatory Imide Drugs and Their Biological Assessment. ACS medicinal chemistry letters 15 (9) (2024)
Rachel Mata
Novel Heteroaryl Fluoroalkenes as DGK Inhibitors for Treating Cancer, Particularly Metastatic Melanoma. ACS medicinal chemistry letters 15 (9) (2024)
Robert B Kargbo
Emerging Techniques in Cancer Therapy: Precision Targeting for Improved Outcomes. ACS medicinal chemistry letters 15 (9) (2024)
Rachel Mata
Novel Triazolopyridine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases. ACS medicinal chemistry letters 15 (9) (2024)
Damian L Stachura, John T Kalyvas, Andrew D Abell
New Potent Sulfonamide-Based Inhibitors of S . aureus Biotin Protein Ligase. ACS medicinal chemistry letters 15 (9) (2024)
Israel Agranat, Ilaria D'Acquarica
Chiral Switches of Tramadol Hydrochloride, a Potential Psychedelic Drug-Past and Future. ACS medicinal chemistry letters 15 (9) (2024)
Shuai Han, Xinyun Guo, Min Wang, Huan Liu, Yidan Song, Yunyun He, Kuang-Lung Hsueh, Weiren Cui, Wenji Su, Letian Kuai, Jason Deng
Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space. ACS medicinal chemistry letters 15 (9) (2024)
Ahmed F Abdel-Magid
Inhibitors of the Cyclic GMP-AMP Synthase (cGAS) as Potential Treatment for Autoimmune and Inflammatory Diseases. ACS medicinal chemistry letters 15 (9) (2024)
Robert B Kargbo
Advancements in Targeted Therapeutics: Integrating Metabolic Modulation, Immune Engineering, and Biologic Formulation Technologies. ACS medicinal chemistry letters 15 (9) (2024)
Minh T Tran, Sandrine Grosse, Rodrigo J Carbajo, Edgar Jacoby, Yanting Yin, Xiaodi Yu, Carol Martinez, Bart Stoops, Ludwig Cooymans, Lili Hu, Ferdinand H Lutter, Serge Pieters, Eric Tan, Jesus Alcázar, Dirk Roymans, Herman W T van Vlijmen, Peter Rigaux, Sujata Sharma, Tim H M Jonckers
Structure-Activity Relationship of Oxacyclo- and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors. ACS medicinal chemistry letters 15 (9) (2024)
Michele Rossi, Bianca Martinengo, Eleonora Diamanti, Alessandra Salerno, Nicola Rizzardi, Romana Fato, Christian Bergamini, Andressa Souza de Oliveira, Thais de Araújo Marques Ferreira, Cleonice Andrade Holanda, Luiz Antonio Soares Romeiro, Maria de Nazaré Correia Soeiro, Krislayne Nunes, Ludmila Ferreira de Almeida Fiuza, Marcos Meuser Batista, Carlos Alberto Manssour Fraga, Hamed E A Alkhalaf, Ehab Kotb Elmahallawy, Godwin U Ebiloma, Harry P de Koning, Serena Vittorio, Vistoli Giulio, Christophe Blanquart, Philippe Bertrand, Maria Laura Bolognesi
Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases. ACS medicinal chemistry letters 15 (9) (2024)
Robert B Kargbo
Current Trends in Psychedelic Science: Integrating Modified Lysergic Acid Derivatives and Psilocybin in Modern Medicine. ACS medicinal chemistry letters 15 (9) (2024)
Ahmed F Abdel-Magid
Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) as Treatment for Inflammatory Diseases. ACS medicinal chemistry letters 15 (9) (2024)
Jeffery A Erickson, Ravikumar Jimmidi, Prashanth Anamthathmakula, Xuan Qin, Jian Wang, Leyi Gong, Jaehyeon Park, Gary Koolpe, Caitlin Tan, Martin M Matzuk, Feng Li, Srinivas Chamakuri, Wipawee Winuthayanon
Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen. ACS medicinal chemistry letters 15 (9) (2024)
Nicholas R Wurtz, Pravin S Shirude, Daniel L Cheney, John A Lupisella, Amit Kumar Chattopadhyay, Vishweshwaraiah Baligar, Balaji Seshadri, Prakash Anjanappa, Andrew Viet, Meriah N Valente, Mei-Yin Hsu, Mojgan Abousleiman, Sanket Sarodaya, Debarati M Tagore, Shailesh Dudhgaonkar, Sivaprasad Putlur, Elizabeth A Dierks, Jacek Ostrowski, Ruth R Wexler, Ricardo Garcia, Ellen K Kick
Discovery and Optimization of Aryl Piperidinone Ureas as Selective Formyl Peptide Receptor 2 Agonists. ACS medicinal chemistry letters 15 (9) (2024)
Andrea Citarella, Miriam Cavinato, Elena Rosini, Haidi Shehi, Federico Ballabio, Carlo Camilloni, Valerio Fasano, Alessandra Silvani, Daniele Passarella, Loredano Pollegioni, Marco Nardini
Nicotinic Acid Derivatives As Novel Noncompetitive α-Amylase and α-Glucosidase Inhibitors for Type 2 Diabetes Treatment. ACS medicinal chemistry letters 15 (9) (2024)
Robert B Kargbo
Innovative Drug Discovery: Targeting Cancer, Neurological Disorders, and Obesity. ACS medicinal chemistry letters 15 (9) (2024)
Junyi Yang, Yanwen He, Youkun Kang, Liteng Shen, Wen Zhang, Yumeng Yan, Xinyi Li, Wenhai Huang, Xiangwei Xu
Virtual Screening and Molecular Docking: Discovering Novel METTL3 Inhibitors. ACS medicinal chemistry letters 15 (9) (2024)
Arunkranthi Maturi, Kasinathuni Naga Visweswara Sastry, Surendra Kumar, Vinay Pogaku, Hyun Jin Kwon, Sung-Min Ahn, Mi-Hyun Kim
Side Chain Investigation of Imidazopyridazine as a Hinge Binder for Targeting Actionable Mutations of RET Kinase. ACS medicinal chemistry letters 15 (9) (2024)
Elisa Patacchini, Valentina Noemi Madia, Aurora Albano, Giuseppe Ruggieri, Antonella Messore, Davide Ialongo, Francesco Saccoliti, Luigi Scipione, Sandro Cosconati, Pratibha C Koneru, Reed Haney, Mamuka Kvaratskhelia, Roberto Di Santo, Roberta Costi
Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase-RNA interactions. ACS medicinal chemistry letters 15 (9) (2024)
Justin Bellenger, Martin R M Koos, Melissa Avery, Mark Bundesmann, Gregory Ciszewski, Bhagyashree Khunte, Carolyn Leverett, Gregory Ostner, Tim F Ryder, Kathleen A Farley
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1 H NMR for Parallel Medicinal Chemistry. ACS medicinal chemistry letters 15 (9) (2024)
Robert B Kargbo
Exploring the Therapeutic Potential of Entheogens in Postoperative Cognitive Decline and Psychological Resilience. ACS medicinal chemistry letters 15 (9) (2024)
Elena Lucarini, Vanessa D'Antogiovanni, Luca Antonioli, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Marta Ferraroni, Maria Locuoco, Antonella Capperucci, Damiano Tanini, Andrea Ageli, Claudiu T Supuran
Study of Chalcogen Aspirin Derivatives with Carbonic Anhydrase Inhibitory Properties for Treating Inflammatory Pain. ACS medicinal chemistry letters 15 (9) (2024)
Qianping Huang, Yuang Gu, An Qin, Peixiang Ma, Hongtao Xu, Shuning Zhang
FSO 2 N 3 -Mediated On-DNA Diazo-Transfer Chemistry. ACS medicinal chemistry letters 15 (9) (2024)
Robert B Kargbo
New Directions in Antibacterial, Anticancer, and Gene Editing Therapies. ACS medicinal chemistry letters 15 (9) (2024)
Rachel Mata
Novel Azepino[4,5- b ]indolone as cGAS Inhibitors for Treating Immune-Mediated Diseases. ACS medicinal chemistry letters 15 (9) (2024)
Jie Li, Nicolás M Morato, Lori S Westover, Pravien Abeywickrema, Jieping Geng, Madison Piassek, David Harden, Iulia I Strambeanu, Zhicai Shi, Robert Graham Cooks, Juncai Meng
High-Throughput Assessment of Bile Salt Export Pump Inhibition Using RapidFire-MS and DESI-MS. ACS medicinal chemistry letters 15 (9) (2024)
Eugen F Mesaros, Andrew G Cole, Steven G Kultgen, Nagraj Mani, Kristi Yi Fan, Benjamin J Dugan, Andrzej Ardzinski, Kim Stever, Holly M Micolochick Steuer, Ingrid E Graves, Sunny Tang, Troy O Harasym, Angela M Lam, Emily P Thi, Bruce D Dorsey, Michael J Sofia
Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators. ACS medicinal chemistry letters 15 (9) (2024)
Zuoyang Wang, Zhichao Shi, Shiqi Yang, Zizhou Niu, Kaifei Shu, Linbo Chen, Cailian Zhi, Funian Liu, Wenjun Huang, Tingting Fan, Yuyang Jiang
Design and Synthesis of c-Met and HDAC Dual Inhibitors for the Treatment of Breast Cancer. ACS medicinal chemistry letters 15 (9) (2024)
Maria-Jesus Blanco, Melissa J Buskes, Rajiv G Govindaraj, Jonathan J Ipsaro, Joann E Prescott-Roy, Anil K Padyana
Allostery Illuminated: Harnessing AI and Machine Learning for Drug Discovery. ACS medicinal chemistry letters 15 (9) (2024)
Aleksandra Baranczak, Simone V Bigi-Botterill, Chiara Borsari, Amanda W Dombrowski, Michelle A Estrada, Mark P Farrell, Andrew P Riley, John G Woodland
Announcing the Early Career Board of ACS Medicinal Chemistry Letters . ACS medicinal chemistry letters 15 (9) (2024)
André Lopes, Sofia Teixeira, Nuno Santarém, Alessandro Greco, Angela Pagliaro, Oliver Keminer, Sheraz Gul, Anabela-Cordeiro da Silva, Maria Alice Carvalho
SAR Study of 4,8-Disubstituted Pyrimido[5,4- d ]pyrimidines Exhibiting Antitrypanosomal and Antileishmanial Activity. ACS medicinal chemistry letters 15 (9) (2024)
Rachel Mata
MALT1 Inhibitors for Treating Cancer and Immunological Diseases. ACS medicinal chemistry letters 15 (9) (2024)
Harmon Greenway, Jin Wang
Evaluation of High-Affinity Monoclonal Antibodies and Antibody-Drug Conjugates by Homogenous Time-Resolved FRET. ACS medicinal chemistry letters 15 (9) (2024)
John C Tellis, Binqing Wei, Michael Siu, Le An, Grace Kayan Chan, Yong Chen, Xiangnan Du, Lewis Gazzard, Baihua Hu, James Kiefer, Satoko Kakiuchi-Kiyota, Michael Lainchbury, Jonathan L Linehan, Xifeng Luo, Sushant Malhotra, Rohan Mendonca, Jodie Pang, Yinqing Ran, Vijay Sethuraman, Eileen Seward, Chris Sneeringer, Dian Su, Weiru Wang, Ping Wu, John G Moffat, Timothy P Heffron, Edna F Choo, Bryan K Chan
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1. ACS medicinal chemistry letters 15 (9) (2024)