X Chris Le

Scopus Author ID ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 55

Top Venues

Analytical chemistry

Angewandte Chemie (International ed. in English)

ACS measurement science au

Environmental science & technology

Univesity of Alberta

University of British Columbia (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Univesity of Alberta Jul 01 2011

Canada

Distinguished University Professor :: Laboratory Medicine and Pathology

University of Alberta Jul 01 2006

Canada

Professor :: Laboratory Medicine and Pathology

University of Alberta Jul 01 2003

Canada

Professor :: Public Health Sciences

University of Alberta Jul 01 2000

Canada

Adjunct Professor :: Chemistry

University of Alberta School of Public Health Jul 01 1999 - Jun 30 2003

Canada

Associate Professor :: Environmental Health Sciences

University of Alberta Feb 01 1995 - Jun 30 1999

Canada

Assistant Professor :: Public Health Sciences

Education History

University of British Columbia Jan 01 1990 - Dec 31 1993

Canada

PHD :: Chemistry

Brock University Jan 01 1987 - Dec 31 1988

Canada

MSC :: Chemistry

Research Centre for Eco-Environmental Sciences Sep 01 1983 - May 31 1986

China

MSC

Wuhan University Sep 01 1979 - Jun 30 1983

China

BSC :: Chemistry

Publications

Hui Wang, Honghong Wang, Hongru Pian, Fengxia Su, Fu Tang, Desheng Chen, Junjie Chen, Yongqiang Wen, X Chris Le, Zhengping Li
CRISPR/Cas13a-Responsive and RNA-Bridged DNA Hydrogel Capillary Sensor for Point-of-Care Detection of RNA. Analytical chemistry 96 (29) (2024)
Hui Wang, Honghong Wang, Hongru Pian, Fengxia Su, Fu Tang, Desheng Chen, Junjie Chen, Yongqiang Wen, X Chris Le, Zhengping Li
CRISPR/Cas13a-Responsive and RNA-Bridged DNA Hydrogel Capillary Sensor for Point-of-Care Detection of RNA. Analytical chemistry 96 (29) (2024)
Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X Chris Le, Qiuquan Wang, Xiaowen Yan
Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment. Journal of medicinal chemistry 67 (7) (2024)
Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X Chris Le, Qiuquan Wang, Xiaowen Yan
Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment. Journal of medicinal chemistry (2024)
Hui Wang, Honghong Wang, Hongru Pian, Fengxia Su, Fu Tang, Desheng Chen, Junjie Chen, Yongqiang Wen, X Chris Le, Zhengping Li
CRISPR/Cas13a-Responsive and RNA-Bridged DNA Hydrogel Capillary Sensor for Point-of-Care Detection of RNA. Analytical chemistry (2024)
Hui Wang, Honghong Wang, Hongru Pian, Fengxia Su, Fu Tang, Desheng Chen, Junjie Chen, Yongqiang Wen, X Chris Le, Zhengping Li
CRISPR/Cas13a-Responsive and RNA-Bridged DNA Hydrogel Capillary Sensor for Point-of-Care Detection of RNA. Analytical chemistry 96 (29) (2024)
Wei Feng, Hanyong Peng, Hongquan Zhang, Michael Weinfeld, X Chris Le
A Sensitive Technique Unravels the Kinetics of Activation and Trans-Cleavage of CRISPR-Cas Systems. Angewandte Chemie (International ed. in English) (2024)
Wei Feng, Hanyong Peng, Hongquan Zhang, Michael Weinfeld, X Chris Le
A Sensitive Technique Unravels the Kinetics of Activation and Trans-Cleavage of CRISPR-Cas Systems. Angewandte Chemie (International ed. in English) 63 (22) (2024)
Aijiao Yuan, Rui Sha, Wenjing Xie, Guangbo Qu, Hongquan Zhang, Hai-Lin Wang, X Chris Le, Gui-Bin Jiang, Hanyong Peng
RNA-Activated CRISPR/Cas12a Nanorobots Operating in Living Cells. Journal of the American Chemical Society (2024)
Hui Wang, Honghong Wang, Hongru Pian, Fengxia Su, Fu Tang, Desheng Chen, Junjie Chen, Yongqiang Wen, X Chris Le, Zhengping Li
CRISPR/Cas13a-Responsive and RNA-Bridged DNA Hydrogel Capillary Sensor for Point-of-Care Detection of RNA. Analytical chemistry 96 (29) (2024)
Jeffrey Tao, Hongquan Zhang, Michael Weinfeld, X Chris Le
Detection of Uracil-Excising DNA Glycosylases in Cancer Cell Samples Using a Three-Dimensional DNAzyme Walker. ACS measurement science au 4 (4) (2024)
Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X Chris Le, Qiuquan Wang, Xiaowen Yan
Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment. Journal of medicinal chemistry 67 (7) (2024)
Wei Feng, Hanyong Peng, Hongquan Zhang, Michael Weinfeld, X Chris Le
A Sensitive Technique Unravels the Kinetics of Activation and Trans-Cleavage of CRISPR-Cas Systems. Angewandte Chemie (International ed. in English) 63 (22) (2024)
Jeffrey Tao, Hongquan Zhang, Michael Weinfeld, X Chris Le
Detection of Uracil-Excising DNA Glycosylases in Cancer Cell Samples Using a Three-Dimensional DNAzyme Walker. ACS measurement science au 4 (4) (2024)
Jeffrey Tao, Hongquan Zhang, Michael Weinfeld, X Chris Le
Development of a DNAzyme Walker for the Detection of APE1 in Living Cancer Cells. Analytical chemistry (2023)
Wei Feng, Hongquan Zhang, X Chris Le
Signal Amplification by the trans -Cleavage Activity of CRISPR-Cas Systems: Kinetics and Performance. Analytical chemistry 95 (1) (2023)
Wei Feng, Hongquan Zhang, X Chris Le
Signal Amplification by the trans -Cleavage Activity of CRISPR-Cas Systems: Kinetics and Performance. Analytical chemistry 95 (1) (2023)
Yanming Liu, Teresa Kumblathan, Michael A Joyce, D Lorne Tyrrell, Graham Tipples, Xiaoli Pang, Xing-Fang Li, X Chris Le
Multiplex Assays Enable Simultaneous Detection and Identification of SARS-CoV-2 Variants of Concern in Clinical and Wastewater Samples. ACS measurement science au 3 (4) (2023)
Karen S Hoy, Tetiana Davydiuk, Xiaojian Chen, Chester Lau, Jordan R M Schofield, Xiufen Lu, Jennifer A Graydon, Ruth Mitchell, Megan Reichert, X Chris Le
Arsenic speciation in freshwater fish: challenges and research needs. Food quality and safety 7 (2023)
Wei Feng, Hongquan Zhang, X Chris Le
Signal Amplification by the trans -Cleavage Activity of CRISPR-Cas Systems: Kinetics and Performance. Analytical chemistry 95 (1) (2023)
Wei Feng, Hongquan Zhang, X Chris Le
Signal Amplification by the trans -Cleavage Activity of CRISPR-Cas Systems: Kinetics and Performance. Analytical chemistry 95 (1) (2023)
Teresa Kumblathan, Yanming Liu, Xiaoli Pang, Steve E Hrudey, X Chris Le, Xing-Fang Li
Quantification and Differentiation of SARS-CoV-2 Variants in Wastewater for Surveillance. Environment & health (Washington, D.C.) 1 (3) (2023)
Tetiana Davydiuk, Jeffrey Tao, Xiufen Lu, X Chris Le
Effects of Dietary Intake of Arsenosugars and Other Organic Arsenic Species on Studies of Arsenic Methylation Efficiency in Humans. Environment & health (Washington, D.C.) 1 (4) (2023)
María Cruz Moreno-Bondi, X Chris Le, Jennifer A Field, Susan D Richardson, Xing-Fang Li, Miriam L Diamond, Xiang-Dong Li, Paul D Goring
From Detection to Remediation: Analytical Science at the Forefront of Environmental Research. Analytical chemistry 94 (43) (2022)
María Cruz Moreno-Bondi, X Chris Le, Jennifer A Field, Susan D Richardson, Xing-Fang Li, Miriam L Diamond, Xiang-Dong Li, Paul D Goring
From Detection to Remediation: Analytical Science at the Forefront of Environmental Research. ACS omega 7 (43) (2022)
María Cruz Moreno-Bondi, X Chris Le, Jennifer A Field, Susan D Richardson, Xing-Fang Li, Miriam L Diamond, Xiang-Dong Li, Paul D Goring
From Detection to Remediation: Analytical Science at the Forefront of Environmental Research. Environmental science & technology 56 (22) (2022)
Yanming Liu, Teresa Kumblathan, Wei Feng, Juan Li, Jeffrey Tao, Jingyang Xu, Huyan Xiao, Michael A Joyce, D Lorne Tyrrell, Hongquan Zhang, Xing-Fang Li, X Chris Le
On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads. ACS measurement science au 2 (3) (2022)
Yanming Liu, Teresa Kumblathan, Wei Feng, Juan Li, Jeffrey Tao, Jingyang Xu, Huyan Xiao, Michael A Joyce, D Lorne Tyrrell, Hongquan Zhang, Xing-Fang Li, X Chris Le
On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads. ACS measurement science au 2 (3) (2022)
Yiren Cao, Jinjun Wu, Juan Li, Hongquan Zhang, X Chris Le
CRISPR/Cas12a-mediated gold nanoparticle aggregation for colorimetric detection of SARS-CoV-2. Chemical communications (Cambridge, England) 57 (56) (2021)
Qingqing Liu, Chengzhi Huang, Wenhui Li, Zhenzheng Fang, X Chris Le
Discovery and Identification of Arsenolipids Using a Precursor-Finder Strategy and Data-Independent Mass Spectrometry. Environmental science & technology 55 (6) (2021)
Wei Feng, Hanyong Peng, Jingyang Xu, Yanming Liu, Kanti Pabbaraju, Graham Tipples, Michael A Joyce, Holly A Saffran, D Lorne Tyrrell, Shawn Babiuk, Hongquan Zhang, X Chris Le
Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA. Analytical chemistry 93 (37) (2021)
Yanan Tang, Lu Gao, Wei Feng, Chen Guo, Qian-Fan Yang, Feng Li, X Chris Le
The CRISPR-Cas toolbox for analytical and diagnostic assay development. Chemical Society reviews 50 (21) (2021)
Jinjun Wu, Hanyong Peng, Xiufen Lu, Maode Lai, Hongquan Zhang, X Chris Le
Binding-Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9. Angewandte Chemie (International ed. in English) 60 (20) (2021)
Wei Feng, Ashley M Newbigging, Jeffrey Tao, Yiren Cao, Hanyong Peng, Connie Le, Jinjun Wu, Juan Li, Juan Li, D Lorne J Tyrrell, Hongquan Zhang, X Chris Le
CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules. Chemical science 12 (13) (2021)
Connie Le, Yanming Liu, Joaquín López-Orozco, Michael A Joyce, X Chris Le, D Lorne Tyrrell
CRISPR Technique Incorporated with Single-Cell RNA Sequencing for Studying Hepatitis B Infection. Analytical chemistry 93 (31) (2021)
X Chris Le
Analytical Advances in Detecting SARS-CoV-2 and Further Research Needs for COVID-19 Testing. Analytical chemistry 93 (24) (2021)
Yiren Cao, Hongquan Zhang, X Chris Le
Split Locations and Secondary Structures of a DNAzyme Critical to Binding-Assembled Multicomponent Nucleic Acid Enzymes for Protein Detection. Analytical chemistry 93 (47) (2021)
Hanyong Peng, Connie Le, Jinjun Wu, Xing-Fang Li, Hongquan Zhang, X Chris Le
A Genome-Editing Nanomachine Constructed with a Clustered Regularly Interspaced Short Palindromic Repeats System and Activated by Near-Infrared Illumination. ACS nano 14 (3) (2020)
Yanming Liu, Connie Le, D Lorne Tyrrell, X Chris Le, Xing-Fang Li
Aptamer Binding Assay for the E Antigen of Hepatitis B Using Modified Aptamers with G-Quadruplex Structures. Analytical chemistry 92 (9) (2020)
Ke Huang, Fan Gao, X Chris Le, Fang-Jie Zhao
N-Hydroxyarylamine O-Acetyltransferases Catalyze Acetylation of 3-Amino-4-Hydroxyphenylarsonic Acid in the 4-Hydroxy-3-Nitrobenzenearsonic Acid Transformation Pathway of Enterobacter sp. Strain CZ-1. Applied and environmental microbiology 86 (2) (2020)
Wei Feng, Ashley M Newbigging, Connie Le, Juan Li, Hanyong Peng, Yiren Cao, Jinjun Wu, Ghulam Abbas, Jin Song, Dian-Bing Wang, Mengmeng Cui, Jeffrey Tao, D Lorne Tyrrell, Xian-En Zhang, Hongquan Zhang, X Chris Le
Molecular Diagnosis of COVID-19: Challenges and Research Needs. Analytical chemistry 92 (15) (2020)
Juan Li, Jingyang Xu, Yanming Liu, Hanyong Peng, Wei Feng, Yiren Cao, Jinjun Wu, Huyan Xiao, Kanti Pabbaraju, Graham Tipples, Michael A Joyce, Holly A Saffran, D Lorne Tyrrell, Hongquan Zhang, X Chris Le
Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology. Analytical chemistry 92 (24) (2020)
Ashley M Newbigging, Hongquan Zhang, X Chris Le
Beacon-mediated exponential amplification reaction (BEAR) using a single enzyme and primer. Chemical communications (Cambridge, England) 55 (72) (2019)
Hanyong Peng, Ashley M Newbigging, Michael S Reid, Jagdeesh S Uppal, Jingyang Xu, Hongquan Zhang, X Chris Le
Signal Amplification in Living Cells: A Review of microRNA Detection and Imaging. Analytical chemistry 92 (1) (2019)
Wei Wang, Yichao Qian, Jinhua Li, Naif Aljuhani, Arno G Siraki, X Chris Le, Xing-Fang Li
Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells. Environmental science & technology 52 (5) (2018)
Michael S Reid, Rebecca E Paliwoda, Hongquan Zhang, X Chris Le
Reduction of Background Generated from Template-Template Hybridizations in the Exponential Amplification Reaction. Analytical chemistry 90 (18) (2018)
Qingqing Liu, Elaine M Leslie, Birget Moe, Hongquan Zhang, Donna N Douglas, Norman M Kneteman, X Chris Le
Metabolism of a Phenylarsenical in Human Hepatic Cells and Identification of a New Arsenic Metabolite. Environmental science & technology 52 (3) (2018)
Feng Li, Yanwen Lin, Alyssa Lau, Yanan Tang, Junbo Chen, X Chris Le
Binding-Induced Molecular Amplifier as a Universal Detection Platform for Biomolecules and Biomolecular Interaction. Analytical chemistry 90 (14) (2018)
Michael S Reid, X Chris Le, Hongquan Zhang
Exponential Isothermal Amplification of Nucleic Acids and Assays for Proteins, Cells, Small Molecules, and Enzyme Activities: An EXPAR Example. Angewandte Chemie (International ed. in English) 57 (37) (2018)
Xiaowen Yan, Hongquan Zhang, Zhixin Wang, Hanyong Peng, Jeffrey Tao, Xing-Fang Li, X Chris Le
Quantitative synthesis of protein-DNA conjugates with 1 : 1 stoichiometry. Chemical communications (Cambridge, England) 54 (54) (2018)
Xiaowen Yan, X Chris Le, Hongquan Zhang
Antibody-Bridged Beacon for Homogeneous Detection of Small Molecules. Analytical chemistry 90 (16) (2018)
Lin Xu, Hongquan Zhang, Xiaowen Yan, Hanyong Peng, Zhixin Wang, Qi Zhang, Peiwu Li, Zhaowei Zhang, X Chris Le
Binding-Induced DNA Dissociation Assay for Small Molecules: Sensing Aflatoxin B1. ACS sensors 3 (12) (2018)
Hanyong Peng, Bin Hu, Qingqing Liu, Jinhua Li, Xing-Fang Li, Hongquan Zhang, X Chris Le
Methylated Phenylarsenical Metabolites Discovered in Chicken Liver. Angewandte Chemie (International ed. in English) 56 (24) (2017)
Hanyong Peng, Ashley M Newbigging, Zhixin Wang, Jeffrey Tao, Wenchan Deng, X Chris Le, Hongquan Zhang
DNAzyme-Mediated Assays for Amplified Detection of Nucleic Acids and Proteins. Analytical chemistry 90 (1) (2017)
Xiaowen Yan, Jinhua Li, Qingqing Liu, Hanyong Peng, Aleksandra Popowich, Zhixin Wang, Xing-Fang Li, X Chris Le
p-Azidophenylarsenoxide: An Arsenical "Bait" for the In Situ Capture and Identification of Cellular Arsenic-Binding Proteins. Angewandte Chemie (International ed. in English) 55 (45) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

X Chris Le