Xiao-Hua Chen (Xiaohua Chen)

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 23

Top Venues

Nature communications

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Journal of medicinal chemistry

Bioconjugate chemistry

Shanghai Institute of Materia Medica, Chinese Academy of Sciences

Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Shanghai Institute of Materia Medica, Chinese Academy of Sciences Jul 01 2015

China

Professor :: Chinese Academy of Sciences Key Laboratory of Receptor Research, and Synthetic Organic & Medicinal Chemistry Laboratory

Salk Institute for Biological Studies / UCSF Jan 05 2012 - Jun 26 2015

United States

Postdoc :: Jack H. Skirball Center for Chemical Biology and Proteomics/ Department of Pharmaceutical Chemistry

Humboldt University of Berlin Nov 01 2009 - Dec 31 2011

Germany

Alexander von Humboldt Postdoctoral Research Fellowship :: Department of Organic and Bioorganic Chemistry

University of Science and Technology of China Aug 01 2008 - Oct 20 2009

China

Research Associate :: Department of Chemistry

Education History

Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences Sep 01 2003 - Jul 01 2008

China

PHD :: Chemistry,

Publications

Hao Hu, Wei Hu, An-Di Guo, Linhui Zhai, Song Ma, Hui-Jun Nie, Bin-Shan Zhou, Tianxian Liu, Xinglong Jia, Xing Liu, Xuebiao Yao, Min-Jia Tan, Xiao-Hua Chen
Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells. Nature communications 15 (1) (2024)
Ke-Nian Yan, Yong-Qiang Nie, Jia-Yu Wang, Guang-Liang Yin, Qia Liu, Hao Hu, Xiaoxia Sun, Xiao-Hua Chen
Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (26) (2024)
Ke-Nian Yan, Yong-Qiang Nie, Jia-Yu Wang, Guang-Liang Yin, Qia Liu, Hao Hu, Xiaoxia Sun, Xiao-Hua Chen
Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (26) (2024)
Yanrui Suo, Kaige Li, Xing Ling, Kenian Yan, Weiwei Lu, Jinfeng Yue, Xiao-Hua Chen, Zhiqiang Duan, Xiaojie Lu
Discovery Small-Molecule p300 Inhibitors Derived from a Newly Developed Indazolone-Focused DNA-Encoded Library. Bioconjugate chemistry 35 (8) (2024)
Hao Hu, Wei Hu, An-Di Guo, Linhui Zhai, Song Ma, Hui-Jun Nie, Bin-Shan Zhou, Tianxian Liu, Xinglong Jia, Xing Liu, Xuebiao Yao, Min-Jia Tan, Xiao-Hua Chen
Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells. Nature communications 15 (1) (2024)
Jing Gao, Xingyu Jiang, Shumin Lei, Wenhao Cheng, Yi Lai, Min Li, Lei Yang, Peifeng Liu, Xiao-Hua Chen, Min Huang, Haijun Yu, Hui-Xiong Xu, Zhiai Xu
A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy. Nature communications 15 (1) (2024)
Hao Hu, Wei Hu, An-Di Guo, Linhui Zhai, Song Ma, Hui-Jun Nie, Bin-Shan Zhou, Tianxian Liu, Xinglong Jia, Xing Liu, Xuebiao Yao, Min-Jia Tan, Xiao-Hua Chen
Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells. Nature communications 15 (1) (2024)
Yanrui Suo, Kaige Li, Xing Ling, Kenian Yan, Weiwei Lu, Jinfeng Yue, Xiao-Hua Chen, Zhiqiang Duan, Xiaojie Lu
Discovery Small-Molecule p300 Inhibitors Derived from a Newly Developed Indazolone-Focused DNA-Encoded Library. Bioconjugate chemistry 35 (8) (2024)
Wen-Jing Wang, Lixin Gao, Simei Wang, Wensi Huang, Xin-Yu Meng, Hao Hu, Ziqiang Chen, Jingya Sun, Yali Yuan, Yubo Zhou, Xingxing Diao, Ruimin Huang, Jia Li, Xiao-Hua Chen
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer. Journal of medicinal chemistry 67 (12) (2024)
Wen-Jing Wang, Lixin Gao, Simei Wang, Wensi Huang, Xin-Yu Meng, Hao Hu, Ziqiang Chen, Jingya Sun, Yali Yuan, Yubo Zhou, Xingxing Diao, Ruimin Huang, Jia Li, Xiao-Hua Chen
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer. Journal of medicinal chemistry (2024)
Ke-Nian Yan, Yong-Qiang Nie, Jia-Yu Wang, Guang-Liang Yin, Qia Liu, Hao Hu, Xiaoxia Sun, Xiao-Hua Chen
Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Jing Gao, Xingyu Jiang, Shumin Lei, Wenhao Cheng, Yi Lai, Min Li, Lei Yang, Peifeng Liu, Xiao-Hua Chen, Min Huang, Haijun Yu, Hui-Xiong Xu, Zhiai Xu
A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy. Nature communications 15 (1) (2024)
Wen-Jing Wang, Lixin Gao, Simei Wang, Wensi Huang, Xin-Yu Meng, Hao Hu, Ziqiang Chen, Jingya Sun, Yali Yuan, Yubo Zhou, Xingxing Diao, Ruimin Huang, Jia Li, Xiao-Hua Chen
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer. Journal of medicinal chemistry 67 (12) (2024)
Ke-Nian Yan, Yong-Qiang Nie, Jia-Yu Wang, Guang-Liang Yin, Qia Liu, Hao Hu, Xiaoxia Sun, Xiao-Hua Chen
Accelerating PROTACs Discovery Through a Direct-to-Biology Platform Enabled by Modular Photoclick Chemistry. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (26) (2024)
Yanrui Suo, Kaige Li, Xing Ling, Kenian Yan, Weiwei Lu, Jinfeng Yue, Xiao-Hua Chen, Zhiqiang Duan, Xiaojie Lu
Discovery Small-Molecule p300 Inhibitors Derived from a Newly Developed Indazolone-Focused DNA-Encoded Library. Bioconjugate chemistry (2024)
Jing Gao, Xingyu Jiang, Shumin Lei, Wenhao Cheng, Yi Lai, Min Li, Lei Yang, Peifeng Liu, Xiao-Hua Chen, Min Huang, Haijun Yu, Hui-Xiong Xu, Zhiai Xu
A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy. Nature communications 15 (1) (2024)
An-Di Guo, Ke-Nian Yan, Hao Hu, Linhui Zhai, Teng-Fei Hu, Haixia Su, Yijia Chi, Jinyin Zha, Yechun Xu, Dongxin Zhao, Xiaojie Lu, Yong-Jiang Xu, Jian Zhang, Min-Jia Tan, Xiao-Hua Chen
Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors. Nature chemistry (2023)
Yandan Bao, Minyan Xing, Naylor Matthew, Xiao-Hua Chen, Xuan Wang, Xiaojie Lu
Macrocyclizing DNA-Linked Peptides via Three-Component Cyclization and Photoinduced Chemistry. Organic letters (2023)
Dan Wei, Han-Lin Wang, Qinghe Zeng, Wenjing Wang, Bingbing Hao, Xule Feng, Peipei Wang, Ning Song, Weijuan Kan, Guifang Huang, Xiaoyu Zhou, Min-Jia Tan, Yubo Zhou, Ruimin Huang, Jia Li, Xiao-Hua Chen
Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer. Journal of medicinal chemistry 64 (19) (2021)
An-Di Guo, Ke-Huan Wu, Xiao-Hua Chen
Light-induced efficient and residue-selective bioconjugation of native proteins via indazolone formation. RSC advances 11 (4) (2021)
Hongtao Tian, Jiale Yang, An-Di Guo, Yu Ran, Yun-Zhi Yang, Bing Yang, Ruimin Huang, Haiming Liu, Xiao-Hua Chen
Genetically Encoded Benzoyllysines Serve as Versatile Probes for Interrogating Histone Benzoylation and Interactions in Living Cells. ACS chemical biology 16 (11) (2021)
An-Di Guo, Dan Wei, Hui-Jun Nie, Hao Hu, Chengyuan Peng, Shao-Tong Li, Ke-Nian Yan, Bin-Shan Zhou, Lei Feng, Chao Fang, Min-Jia Tan, Ruimin Huang, Xiao-Hua Chen
Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation. Nature communications 11 (1) (2020)
Hui-Jun Nie, An-Di Guo, Hai-Xia Lin, Xiao-Hua Chen
Rapid and halide compatible synthesis of 2- N -substituted indazolone derivatives via photochemical cyclization in aqueous media. RSC advances 9 (23) (2019)

Xiao-Hua Chen.css-eqlu8i{font-size:small;padding-left:4px;} (Xiaohua Chen)

Publication Activity (10 Years)

Top Topics

Top Venues

Xiao-Hua Chen (Xiaohua Chen)