Yechun Xu

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 44

Top Venues

Journal of medicinal chemistry

Nature communications

ACS medicinal chemistry letters

Cell research

Shanghai Institute of Materia Medica Chinese Academy of Sciences

Shanghai Institute of Materia Medica Chinese Academy of Sciences (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Shanghai Institute of Materia Medica Chinese Academy of Sciences

China

principal investigator :: Drug Discovery and Design Center

Weizmann Institute of Science

Israel

post-doc :: Department of Structural Biology

Education History

Shanghai Institute of Materia Medica Chinese Academy of Sciences

China

PHD :: Drug Discovery and Design Center

Publications

Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Zhidong Jiang, Bo Feng, Lu Chen, Tianqing Nie, Shizhao Chen, Li Wang, Hui Liu, Ting Yu, Yumin Zhang, Miao Zheng, Yechun Xu, Hong Liu, Yi Zang, Haixia Su, Lei-Ke Zhang, Jia Li, Yu Zhou
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CL pro Inhibitors as anti-SARS-CoV-2 Drug Candidate. Journal of medicinal chemistry (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Xudong Wang, Ying Zhu, Qingyi Zhao, Weiwei Lu, Yechun Xu, Hangchen Hu, Xiaojie Lu
Chemical Space Profiling of SARS-CoV-2 PL pro Using DNA-Encoded Focused Libraries. ACS medicinal chemistry letters 15 (4) (2024)
Xudong Wang, Ying Zhu, Qingyi Zhao, Weiwei Lu, Yechun Xu, Hangchen Hu, Xiaojie Lu
Chemical Space Profiling of SARS-CoV-2 PL pro Using DNA-Encoded Focused Libraries. ACS medicinal chemistry letters 15 (4) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
Zhidong Jiang, Bo Feng, Lu Chen, Tianqing Nie, Shizhao Chen, Li Wang, Hui Liu, Ting Yu, Yumin Zhang, Miao Zheng, Yechun Xu, Hong Liu, Yi Zang, Haixia Su, Lei-Ke Zhang, Jia Li, Yu Zhou
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CL pro Inhibitors as anti-SARS-CoV-2 Drug Candidate. Journal of medicinal chemistry 67 (15) (2024)
Xudong Wang, Ying Zhu, Qingyi Zhao, Weiwei Lu, Yechun Xu, Hangchen Hu, Xiaojie Lu
Chemical Space Profiling of SARS-CoV-2 PL pro Using DNA-Encoded Focused Libraries. ACS medicinal chemistry letters 15 (4) (2024)
Chenming Gu, Jiayuan Liu, Fei Qian, Wenchao Yu, Doudou Huang, Jingshan Shen, Chen-Guo Feng, Kaixian Chen, Yiming Li, Xiangrui Jiang, Yechun Xu, Liuqiang Zhang
Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model. Journal of medicinal chemistry 67 (6) (2024)
Chenming Gu, Jiayuan Liu, Fei Qian, Wenchao Yu, Doudou Huang, Jingshan Shen, Chen-Guo Feng, Kaixian Chen, Yiming Li, Xiangrui Jiang, Yechun Xu, Liuqiang Zhang
Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model. Journal of medicinal chemistry (2024)
Zhidong Jiang, Bo Feng, Lu Chen, Tianqing Nie, Shizhao Chen, Li Wang, Hui Liu, Ting Yu, Yumin Zhang, Miao Zheng, Yechun Xu, Hong Liu, Yi Zang, Haixia Su, Lei-Ke Zhang, Jia Li, Yu Zhou
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CL pro Inhibitors as anti-SARS-CoV-2 Drug Candidate. Journal of medicinal chemistry 67 (15) (2024)
Chenming Gu, Jiayuan Liu, Fei Qian, Wenchao Yu, Doudou Huang, Jingshan Shen, Chen-Guo Feng, Kaixian Chen, Yiming Li, Xiangrui Jiang, Yechun Xu, Liuqiang Zhang
Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model. Journal of medicinal chemistry 67 (6) (2024)
Weiqiang Lu, Jiayan Cui, Wanyan Wang, Qian Hu, Yun Xue, Xi Liu, Ting Gong, Yiping Lu, Hui Ma, Xinyu Yang, Bo Feng, Qi Wang, Naixia Zhang, Yechun Xu, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Hongbin Ji, Jin Huang
PPIA dictates NRF2 stability to promote lung cancer progression. Nature communications 15 (1) (2024)
An-Di Guo, Ke-Nian Yan, Hao Hu, Linhui Zhai, Teng-Fei Hu, Haixia Su, Yijia Chi, Jinyin Zha, Yechun Xu, Dongxin Zhao, Xiaojie Lu, Yong-Jiang Xu, Jian Zhang, Min-Jia Tan, Xiao-Hua Chen
Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors. Nature chemistry (2023)
Xiangrui Jiang, Haixia Su, Weijuan Shang, Feng Zhou, Yan Zhang, Wenfeng Zhao, Qiumeng Zhang, Hang Xie, Lei Jiang, Tianqing Nie, Feipu Yang, Muya Xiong, Xiaoxing Huang, Minjun Li, Ping Chen, Shaoping Peng, Geng-Fu Xiao, Hualiang Jiang, Renhong Tang, Lei-Ke Zhang, Jingshan Shen, Yechun Xu
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir. Nature communications 14 (1) (2023)
Qiang Shao, Muya Xiong, Jiameng Li, Hangchen Hu, Haixia Su, Yechun Xu
Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches. Chemical science 14 (18) (2023)
Mengyu Guo, Muya Xiong, Jinying Peng, Tong Guan, Haixia Su, Yanyi Huang, Cai-Guang Yang, Yang Li, Diana Boraschi, Thanigaimalai Pillaiyar, Guanbo Wang, Chengqi Yi, Yechun Xu, Chunying Chen
Multi-omics for COVID-19: driving development of therapeutics and vaccines. National science review 10 (9) (2023)
Qiang Shao, Muya Xiong, Jiameng Li, Hangchen Hu, Haixia Su, Yechun Xu
Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches. Chemical science 14 (18) (2023)
Xinwei Wang, Mu Wang, Tuo Xu, Ye Feng, Qiang Shao, Shuo Han, Xiaojing Chu, Yechun Xu, Shuling Lin, Qiang Zhao, Beili Wu
Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell research (2023)
Pengxuan Ren, Hui Li, Tianqing Nie, Xiaoqin Jian, Changyue Yu, Jian Li, Haixia Su, Xianglei Zhang, Shiwei Li, Xin Yang, Chao Peng, Yue Yin, Lei-Ke Zhang, Yechun Xu, Hong Liu, Fang Bai
Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group. Journal of medicinal chemistry (2023)
Thanigaimalai Pillaiyar, Philipp Flury, Nadine Krüger, Haixia Su, Laura Schäkel, Elany Barbosa da Silva, Olga Eppler, Thales Kronenberger, Tianqing Nie, Stephanie Luedtke, Cheila Rocha, Katharina Sylvester, Marvin R I Petry, James H McKerrow, Antti Poso, Stefan Pöhlmann, Michael Gütschow, Anthony J O'Donoghue, Yechun Xu, Christa Elisabeth Müller, Stefan A Laufer
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination. Journal of medicinal chemistry 65 (13) (2022)
Zhengsheng Zhan, Yinchun Ji, Haixia Su, Chen Fang, Xia Peng, Qiufeng Liu, Yang Dai, Dongze Lin, Yechun Xu, Jing Ai, Wenhu Duan
Discovery of 10 H -Benzo[ b ]pyrido[2,3- e ][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. Journal of medicinal chemistry (2022)
Hangchen Hu, Qian Wang, Haixia Su, Qiang Shao, Wenfeng Zhao, Guofeng Chen, Minjun Li, Yechun Xu
Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease. Angewandte Chemie (International ed. in English) (2022)
Zhengsheng Zhan, Yinchun Ji, Haixia Su, Chen Fang, Xia Peng, Qiufeng Liu, Yang Dai, Dongze Lin, Yechun Xu, Jing Ai, Wenhu Duan
Discovery of 10 H -Benzo[ b ]pyrido[2,3- e ][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. Journal of medicinal chemistry 66 (1) (2022)
Zhengsheng Zhan, Yinchun Ji, Haixia Su, Chen Fang, Xia Peng, Qiufeng Liu, Yang Dai, Dongze Lin, Yechun Xu, Jing Ai, Wenhu Duan
Discovery of 10 H -Benzo[ b ]pyrido[2,3- e ][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. Journal of medicinal chemistry 66 (1) (2022)
Zhengsheng Zhan, Yinchun Ji, Haixia Su, Chen Fang, Xia Peng, Qiufeng Liu, Yang Dai, Dongze Lin, Yechun Xu, Jing Ai, Wenhu Duan
Discovery of 10 H -Benzo[ b ]pyrido[2,3- e ][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. Journal of medicinal chemistry 66 (1) (2022)
Yuanchao Xie, Wanchao Yin, Yumin Zhang, Weijuan Shang, Zhen Wang, Xiaodong Luan, Guanghui Tian, Haji A Aisa, Yechun Xu, Gengfu Xiao, Jia Li, Hualiang Jiang, Shu-Yang Zhang, Lei-Ke Zhang, H Eric Xu, Jingshan Shen
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2. Cell research 31 (11) (2021)
Wenhao Dai, Dirk Jochmans, Hang Xie, Hang Yang, Jian Li, Haixia Su, Di Chang, Jiang Wang, Jingjing Peng, Lili Zhu, Yong Nian, Rolf Hilgenfeld, Hualiang Jiang, Kaixian Chen, Lei-Ke Zhang, Yechun Xu, Johan Neyts, Hong Liu
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. Journal of medicinal chemistry (2021)
Muya Xiong, Haixia Su, Wenfeng Zhao, Hang Xie, Qiang Shao, Yechun Xu
What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design. Medicinal research reviews 41 (4) (2021)
Haixia Su, Sheng Yao, Wenfeng Zhao, Yumin Zhang, Jia Liu, Qiang Shao, Qingxing Wang, Minjun Li, Hang Xie, Weijuan Shang, Changqiang Ke, Lu Feng, Xiangrui Jiang, Jingshan Shen, Gengfu Xiao, Hualiang Jiang, Lei-Ke Zhang, Yang Ye, Yechun Xu
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nature communications 12 (1) (2021)
Hui Zhang, Kun Chen, Qiuxiang Tan, Qiang Shao, Shuo Han, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu, Yechun Xu, Qiang Zhao, Beili Wu
Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nature communications 12 (1) (2021)
Yu Zhou, Yan Fu, Wanchao Yin, Jian Li, Wei Wang, Fang Bai, Shengtao Xu, Qi Gong, Tao Peng, Yu Hong, Dong Zhang, Dan Zhang, Qiufeng Liu, Yechun Xu, H Eric Xu, Hai Yan Zhang, Hualiang Jiang, Hong Liu
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate. Journal of medicinal chemistry 64 (4) (2021)
Wenfeng Zhao, Muya Xiong, Xiaojing Yuan, Minjun Li, Hong-Bin Sun, Yechun Xu
In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing. Journal of chemical information and modeling 60 (6) (2020)
Tong Chen, Muya Xiong, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D Ye, Yechun Xu, Qiang Zhao, Beili Wu
Structural basis of ligand binding modes at the human formyl peptide receptor 2. Nature communications 11 (1) (2020)
Yifan Fu, Xiaoyu Ding, Xianglei Zhang, Xingcheng Shao, Jihui Zhao, Yechun Xu, Xiaomin Luo, Wei-Min Zhao
Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity. Journal of natural products 83 (4) (2020)
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zheng-Li Shi, Hualiang Jiang, Zihe Rao, Haitao Yang
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature 582 (7811) (2020)
Haixia Su, Yi Zou, Guofeng Chen, Huixia Dou, Hang Xie, Xiaojing Yuan, Xianglei Zhang, Naixia Zhang, Minjun Li, Yechun Xu
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation. Journal of medicinal chemistry 63 (8) (2020)
Fubao Huang, Hangchen Hu, Kai Wang, Chengyuan Peng, Wenwei Xu, Yu Zhang, Jing Gao, Yishen Liu, Hu Zhou, Ruimin Huang, Minjun Li, Jianhua Shen, Yechun Xu
Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach. Journal of medicinal chemistry 63 (13) (2020)
Zhen Wang, Xiangrui Jiang, Xianglei Zhang, Guanghui Tian, Rulei Yang, Jianzhong Wu, Xiaoli Zou, Zheng Liu, Xiaojun Yang, Chunhui Wu, Jing Shi, Jianfeng Li, Jin Suo, Yu Wang, Rongxia Zhang, Zhijian Xu, Xudong Gong, Yang He, Jianming Zhu, Haji Akber Aisa, Hualiang Jiang, Yechun Xu, Jingshan Shen
Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. Journal of medicinal chemistry 62 (10) (2019)
Yulan Wang, Yang Dai, Xiaowei Wu, Fei Li, Bo Liu, Chunpu Li, Qiufeng Liu, Yuanyang Zhou, Bao Wang, Mingrui Zhu, Rongrong Cui, Xiaoqin Tan, Zhaoping Xiong, Jia Liu, Min-Jia Tan, Yechun Xu, Meiyu Geng, Hualiang Jiang, Hong Liu, Jing Ai, Mingyue Zheng
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. Journal of medicinal chemistry 62 (16) (2019)
Xianglei Zhang, Guangyu Dong, Heng Li, Wuyan Chen, Jian Li, Chunlan Feng, Zhanni Gu, Fenghua Zhu, Rui Zhang, Minjun Li, Wei Tang, Hong Liu, Yechun Xu
Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent. Journal of medicinal chemistry 62 (11) (2019)
Xiaojing Yuan, Stefano Raniolo, Vittorio Limongelli, Yechun Xu
The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor. Journal of chemical theory and computation 14 (5) (2018)
Hangchen Hu, Zhaoqiang Chen, Xiang Xu, Yechun Xu
Structure-Based Survey of the Binding Modes of BACE1 Inhibitors. ACS chemical neuroscience 10 (2) (2018)
Qiufeng Liu, Fubao Huang, Xiaojing Yuan, Kai Wang, Yi Zou, Jianhua Shen, Yechun Xu
Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. Journal of medicinal chemistry 60 (24) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Yechun Xu