Ya-Dong Chen (Yadong Chen)

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 39

Top Topics

Rheumatoid Arthritis

High Efficiency

Top Venues

Journal of medicinal chemistry

Journal of chemical information and modeling

Science advances

ACS combinatorial science

This page only lists publications with an associated author ORCID identifier.

Publications

Nanxia Zhang, Shige Shen, Mengyu Yang, Sijie He, Chunxiao Liu, Hongmei Li, Tao Lu, Haichun Liu, Qing-Hua Hu, Weifang Tang, Ya-Dong Chen
Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment. Journal of medicinal chemistry 67 (7) (2024)
Xiaohe Xu, Weijie Han, Xiangzhen Ning, Chengdong Zang, Chengcheng Xu, Chen Zeng, Chengtao Pu, Haichun Liu, Ya-Dong Chen, Haichun Liu
Constructing Innovative Covalent and Noncovalent Compound Libraries: Insights from 3D Protein-Ligand Interactions. Journal of chemical information and modeling 64 (5) (2024)
Nanxia Zhang, Shige Shen, Mengyu Yang, Sijie He, Chunxiao Liu, Hongmei Li, Tao Lu, Haichun Liu, Qing-Hua Hu, Weifang Tang, Ya-Dong Chen
Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment. Journal of medicinal chemistry 67 (7) (2024)
Chengtao Pu, Lingxi Gu, Yuxuan Hu, Weijie Han, Xiaohe Xu, Haichun Liu, Ya-Dong Chen, Haichun Liu
Prediction of Human Liver Microsome Clearance with Chirality-Focused Graph Neural Networks. Journal of chemical information and modeling (2024)
Nanxia Zhang, Shige Shen, Mengyu Yang, Sijie He, Chunxiao Liu, Hongmei Li, Tao Lu, Haichun Liu, Qing-Hua Hu, Weifang Tang, Ya-Dong Chen
Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment. Journal of medicinal chemistry (2024)
Xiaohe Xu, Weijie Han, Xiangzhen Ning, Chengdong Zang, Chengcheng Xu, Chen Zeng, Chengtao Pu, Haichun Liu, Ya-Dong Chen, Haichun Liu
Constructing Innovative Covalent and Noncovalent Compound Libraries: Insights from 3D Protein-Ligand Interactions. Journal of chemical information and modeling 64 (5) (2024)
Yong Wang, Chunyue Xu, Yiqing Jiang, Zhenlin Tu, Jingxue Yan, Leyi Guo, Chao Dong, Jiaqi Liu, Xiulong Yang, Ziyi Wang, Tao Lu, Jie Feng, Ya-Dong Chen
Advanced Design, Synthesis, and Evaluation of Highly Selective Wee1 Inhibitors: Enhancing Pharmacokinetics and Antitumor Efficacy. Journal of medicinal chemistry (2024)
Xiaohe Xu, Weijie Han, Xiangzhen Ning, Chengdong Zang, Chengcheng Xu, Chen Zeng, Chengtao Pu, Haichun Liu, Ya-Dong Chen, Haichun Liu
Constructing Innovative Covalent and Noncovalent Compound Libraries: Insights from 3D Protein-Ligand Interactions. Journal of chemical information and modeling 64 (5) (2024)
Yong Wang, Chunyue Xu, Yiqing Jiang, Zhenlin Tu, Jingxue Yan, Leyi Guo, Chao Dong, Jiaqi Liu, Xiulong Yang, Ziyi Wang, Tao Lu, Jie Feng, Ya-Dong Chen
Advanced Design, Synthesis, and Evaluation of Highly Selective Wee1 Inhibitors: Enhancing Pharmacokinetics and Antitumor Efficacy. Journal of medicinal chemistry 67 (12) (2024)
Yong Wang, Chunyue Xu, Yiqing Jiang, Zhenlin Tu, Jingxue Yan, Leyi Guo, Chao Dong, Jiaqi Liu, Xiulong Yang, Ziyi Wang, Tao Lu, Jie Feng, Ya-Dong Chen
Advanced Design, Synthesis, and Evaluation of Highly Selective Wee1 Inhibitors: Enhancing Pharmacokinetics and Antitumor Efficacy. Journal of medicinal chemistry 67 (12) (2024)
Xiaohe Xu, Weijie Han, Xiangzhen Ning, Chengdong Zang, Chengcheng Xu, Chen Zeng, Chengtao Pu, Haichun Liu, Ya-Dong Chen, Haichun Liu
Constructing Innovative Covalent and Noncovalent Compound Libraries: Insights from 3D Protein-Ligand Interactions. Journal of chemical information and modeling (2024)
Xiaohe Xu, Weijie Han, Xiangzhen Ning, Chengdong Zang, Chengcheng Xu, Chen Zeng, Chengtao Pu, Haichun Liu, Ya-Dong Chen, Haichun Liu
Constructing Innovative Covalent and Noncovalent Compound Libraries: Insights from 3D Protein-Ligand Interactions. Journal of chemical information and modeling 64 (5) (2024)
Chengtao Pu, Lingxi Gu, Yuxuan Hu, Weijie Han, Xiaohe Xu, Haichun Liu, Ya-Dong Chen, Haichun Liu
Prediction of Human Liver Microsome Clearance with Chirality-Focused Graph Neural Networks. Journal of chemical information and modeling 64 (14) (2024)
Wenqiang Zhang, Siqi Zhao, Yi Luo, Yan Zhang, Yunrui Feng, Feng Tang, Xiaoyu Zhou, Shaoping Peng, Yawen Fan, Shaofei Xie, Hongmei Li, Qianlong Lai, Lingsheng Fu, Yi Luo, Sheng Pei, Zhuolin Chen, Tao Lu, Renhong Tang, Ya-Dong Chen, Yu Jiao
Discovery of (2 S )- N -(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. Journal of medicinal chemistry 67 (1) (2023)
Wenqiang Zhang, Siqi Zhao, Yi Luo, Yan Zhang, Yunrui Feng, Feng Tang, Xiaoyu Zhou, Shaoping Peng, Yawen Fan, Shaofei Xie, Hongmei Li, Qianlong Lai, Lingsheng Fu, Yi Luo, Sheng Pei, Zhuolin Chen, Tao Lu, Renhong Tang, Ya-Dong Chen, Yu Jiao
Discovery of (2 S )- N -(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. Journal of medicinal chemistry 67 (1) (2023)
Yuan Yuan Li, Lingfeng Chen, Chengtao Pu, Chengdong Zang, YingChao Yan, Ya-Dong Chen, Haichun Liu, Haichun Liu
Co-model for chemical toxicity prediction based on multi-task deep learning. Molecular informatics (2023)
Wenqiang Zhang, Siqi Zhao, Yi Luo, Yan Zhang, Yunrui Feng, Feng Tang, Xiaoyu Zhou, Shaoping Peng, Yawen Fan, Shaofei Xie, Hongmei Li, Qianlong Lai, Lingsheng Fu, Yi Luo, Sheng Pei, Zhuolin Chen, Tao Lu, Renhong Tang, Ya-Dong Chen, Yu Jiao
Discovery of (2 S )- N -(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. Journal of medicinal chemistry 67 (1) (2023)
Zhijie Wang, Li Yin, Zhenghan Xiong, Fei Huang, Na Yang, Fei Jiang, Huili Li, Yong Cui, Jiwei Ren, Zitian Cheng, Kun Jia, Tao Lu, Jiapeng Zhu, Qing-Hua Hu, Ya-Dong Chen
Discovery of a Bromodomain and Extra Terminal Domain (BET) Inhibitor with the Selectivity for the Second Bromodomain (BD2) and the Capacity for the Treatment of Inflammatory Diseases. Journal of medicinal chemistry (2023)
Wenqiang Zhang, Siqi Zhao, Yi Luo, Yan Zhang, Yunrui Feng, Feng Tang, Xiaoyu Zhou, Shaoping Peng, Yawen Fan, Shaofei Xie, Hongmei Li, Qianlong Lai, Lingsheng Fu, Yi Luo, Sheng Pei, Zhuolin Chen, Tao Lu, Renhong Tang, Ya-Dong Chen, Yu Jiao
Discovery of (2 S )- N -(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. Journal of medicinal chemistry (2023)
Yingchao Yan, Yang Zhao, Huifeng Yao, Jie Feng, Li Liang, Weijie Han, Xiaohe Xu, Chengtao Pu, Chengdong Zang, Lingfeng Chen, Yuanyuan Li, Haichun Liu, Tao Lu, Ya-Dong Chen, Haichun Liu
RPBP: Deep Retrosynthesis Reaction Prediction Based on Byproducts. Journal of chemical information and modeling (2023)
Xu Qian, Xiaowen Dai, Lin Luo, Mingde Lin, Yuan Xu, Yang Zhao, Dingfang Huang, Haodi Qiu, Li Liang, Haichun Liu, Yingbo Liu, Lingxi Gu, Tao Lu, Ya-Dong Chen, Haichun Liu
An Interpretable Multitask Framework BiLAT Enables Accurate Prediction of Cyclin-Dependent Protein Kinase Inhibitors. Journal of chemical information and modeling (2023)
Yi Hua, Xiaobao Fang, Guomeng Xing, Yuan Xu, Li Liang, Chenglong Deng, Xiaowen Dai, Haichun Liu, Tao Lu, Haichun Liu, Ya-Dong Chen
Effective Reaction-Based De Novo Strategy for Kinase Targets: A Case Study on MERTK Inhibitors. Journal of chemical information and modeling 62 (7) (2022)
Wuchen Xie, Siyu Yang, Li Liang, Meng Wang, Wen Zuo, Yan Lei, Haichun Liu, Weifang Tang, Tao Lu, Ya-Dong Chen, Yulei Jiang
Discovery of 2-Amino-7-sulfonyl-7 H -pyrrolo[2,3- d ]pyrimidine Derivatives as Potent Reversible FGFR Inhibitors with Gatekeeper Mutation Tolerance: Design, Synthesis, and Biological Evaluation. Journal of medicinal chemistry (2022)
Xiaowen Dai, Yuan Xu, Haodi Qiu, Xu Qian, Mingde Lin, Lin Luo, Yang Zhao, Dingfang Huang, Haichun Liu, Ya-Dong Chen, Haichun Liu, Yulei Jiang
KID: A Kinase-Focused Interaction Database and Its Application in the Construction of Kinase-Focused Molecule Databases. Journal of chemical information and modeling (2022)
Chao Dong, Yong Wang, Zhenlin Tu, Jingxue Yan, Yiqing Jiang, Tao Lu, Ya-Dong Chen, Haichun Liu
Recent advances in ATM inhibitors as potential therapeutic agents. Future medicinal chemistry (2022)
Zhijie Wang, Jiongheng Cai, Jie Cheng, Wenqianzi Yang, Yifan Zhu, Hongmei Li, Tao Lu, Ya-Dong Chen, Shuai Lu
FLT3 Inhibitors in Acute Myeloid Leukemia: Challenges and Recent Developments in Overcoming Resistance. Journal of medicinal chemistry 64 (6) (2021)
Jianhang Huang, Xinren Wang, Ruinan Dong, Xiaoyue Liu, Hongmei Li, Tianyi Zhang, Junyu Xu, Chenhe Liu, Yanmin Zhang, Shaohua Hou, Weifang Tang, Tao Lu, Ya-Dong Chen
Discovery of N-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-4-(4-methylpiperazin-1-yl)quinazolin-7-amine as a Novel, Potent, and Oral Cyclin-Dependent Kinase Inhibitor against Haematological Malignancies. Journal of medicinal chemistry 64 (17) (2021)
Zhijie Wang, Jiongheng Cai, Jiwei Ren, Yun Chen, Yingli Wu, Jie Cheng, Kun Jia, Fei Huang, Zitian Cheng, Tiancheng Sheng, Shiyu Song, Hao Heng, Yifan Zhu, Weifang Tang, Hongmei Li, Tao Lu, Ya-Dong Chen, Shuai Lu
Discovery of a Potent FLT3 Inhibitor (LT-850-166) with the Capacity of Overcoming a Variety of FLT3 Mutations. Journal of medicinal chemistry 64 (19) (2021)
Yuqin Zhu, Yuxiang Ma, Weidong Zu, Jianing Song, Hua Wang, You Zhong, Hongmei Li, Haichun Liu, Qianqian Gao, Bo Kong, Junyu Xu, Fei Jiang, Xinren Wang, Shuwen Li, Chenhe Liu, Haichun Liu, Tao Lu, Ya-Dong Chen
Identification of N-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis. Journal of medicinal chemistry 63 (13) (2020)
Xingye Chen, Wuchen Xie, Yan Yang, Yi Hua, GuoMeng Xing, Li Liang, Chenglong Deng, Yuchen Wang, Yuanrong Fan, Haichun Liu, Tao Lu, Ya-Dong Chen, Haichun Liu
Discovery of Dual FGFR4 and EGFR Inhibitors by Machine Learning and Biological Evaluation. Journal of chemical information and modeling 60 (10) (2020)
Guomeng Xing, Li Liang, Chenglong Deng, Yi Hua, Xingye Chen, Yan Yang, Haichun Liu, Tao Lu, Ya-Dong Chen, Haichun Liu
Activity Prediction of Small Molecule Inhibitors for Antirheumatoid Arthritis Targets Based on Artificial Intelligence. ACS combinatorial science 22 (12) (2020)
Yan Yang, Haichun Liu, Yi Hua, Xingye Chen, Yuanrong Fan, Yuchen Wang, Li Liang, Chenglong Deng, Tao Lu, Ya-Dong Chen, Haichun Liu
In Silico Design and Analysis of a Kinase-Focused Combinatorial Library Considering Diversity and Quality. Journal of chemical information and modeling 60 (1) (2020)
Hong-Mei Li, Yan-Ran Bi, Yang Li, Rong Fu, Wen-Cong Lv, Nan Jiang, Ying Xu, Bo-Xue Ren, Ya-Dong Chen, Hui Xie, Shui Wang, Tao Lu, Zhao-Qiu Wu
A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer. Science advances 6 (17) (2020)
Yuanrong Fan, Haichun Liu, Yi Hua, Yuchen Wang, Lu Zhu, Junnan Zhao, Yan Yang, Xingye Chen, Shuai Lu, Tao Lu, Ya-Dong Chen, Haichun Liu
Investigation of Machine Intelligence in Compound Cell Activity Classification. Molecular pharmaceutics 16 (11) (2019)
Yuchen Wang, Shaohua Hou, Yu Tong, Hongmei Li, Yi Hua, Yuanrong Fan, Xingye Chen, Yan Yang, Haichun Liu, Tao Lu, Ya-Dong Chen, Haichun Liu
Discovery of potent apoptosis signal-regulating kinase 1 inhibitors via integrated computational strategy and biological evaluation. Journal of biomolecular structure & dynamics 38 (15) (2019)
Yuchen Wang, Haichun Liu, Yuanrong Fan, Xingye Chen, Yan Yang, Lu Zhu, Junnan Zhao, Ya-Dong Chen, Haichun Liu
In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy. Journal of chemical information and modeling 59 (9) (2019)
Fei Jiang, Qinghua Hu, Zhimin Zhang, Hongmei Li, Huili Li, Dewei Zhang, Hanwen Li, Yu Ma, Jingjing Xu, Haifang Chen, Yong Cui, Yan-Le Zhi, Yanmin Zhang, Junyu Xu, Jiapeng Zhu, Tao Lu, Ya-Dong Chen
Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis. Journal of medicinal chemistry 62 (24) (2019)
Xingye Chen, Haichun Liu, Wuchen Xie, Yan Yang, Yuchen Wang, Yuanrong Fan, Yi Hua, Lu Zhu, Junnan Zhao, Tao Lu, Ya-Dong Chen, Haichun Liu
Investigation of Crystal Structures in Structure-Based Virtual Screening for Protein Kinase Inhibitors. Journal of chemical information and modeling 59 (12) (2019)
Hui Xu, Yuchen Wang, Peter W Jurutka, Shen Wu, Ya-Dong Chen, Chongjiang Cao, Guitang Chen, Bei Tian, Suilou Wang, Shujie Cheng
16α-Hydroxytrametenolic Acid from Poria cocos Improves Intestinal Barrier Function Through the Glucocorticoid Receptor-Mediated PI3K/Akt/NF-κB Pathway. Journal of agricultural and food chemistry 67 (39) (2019)