Yu Chen

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 36

Top Venues

Emerging microbes & infections

Signal transduction and targeted therapy

Science translational medicine

Cell death & disease

College of Life Sciences, Wuhan University

Wuhan University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

College of Life Sciences, Wuhan University Dec 01 2016

China

PI / Professor :: State Key Laboratory of Virology

Education History

Wuhan University Sep 01 2003 - Jun 30 2009

China

PHD :: Department of Microbiology

Publications

Qianyun Liu, Yuchi Lu, Chenguang Cai, Yanyan Huang, Li Zhou, Yanbin Guan, Shiying Fu, Youyou Lin, Huan Yan, Zhen Zhang, Xiang Li, Xiu-Na Yang, Haitao Yang, Hangtian Guo, Ke Lan, Yu Chen, Shin-Chen Hou, Yi Xiong
A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug. Cell death & disease 15 (6) (2024)
Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen
The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development. Emerging microbes & infections 13 (1) (2024)
Hongyun Wang, Jiangpeng Feng, Zhiying Fu, Tianmo Xu, Jiejie Liu, Shimin Yang, Yingjian Li, Jikai Deng, Yuzhen Zhang, Ming Guo, Xin Wang, Zhen Zhang, Zhixiang Huang, Ke Lan, Li Zhou, Yu Chen
Epitranscriptomic m 5 C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection. Science advances 10 (32) (2024)
Xian Li, Mengxin Xu, Jingyi Yang, Li Zhou, Lin Liu, Min Li, Shasha Wang, Mei-Qin Liu, Zhixiang Huang, Zhen Zhang, Shuning Liu, Yunqi Hu, Haofeng Lin, Bowen Liu, Ying Sun, Qingguo Wu, Zheng-Li Shi, Ke Lan, Yu Chen, Huimin Yan, Yao-Qing Chen
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1. Signal transduction and targeted therapy 9 (1) (2024)
Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen
The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development. Emerging microbes & infections 13 (1) (2024)
Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan, Jiejie Liu, Yanying Yu, Qiang Ding, Chengpeng Fan, Hongyun Wang, Xianyin Chen, Qianyun Liu, Xiao Guo, Feiyu Gong, Li Zhou, Yu Chen
Natural evidence of coronaviral 2'-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding. Signal transduction and targeted therapy 9 (1) (2024)
Hongyun Wang, Jiangpeng Feng, Zhiying Fu, Tianmo Xu, Jiejie Liu, Shimin Yang, Yingjian Li, Jikai Deng, Yuzhen Zhang, Ming Guo, Xin Wang, Zhen Zhang, Zhixiang Huang, Ke Lan, Li Zhou, Yu Chen
Epitranscriptomic m 5 C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection. Science advances 10 (32) (2024)
Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen
The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development. Emerging microbes & infections 13 (1) (2024)
Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan, Jiejie Liu, Yanying Yu, Qiang Ding, Chengpeng Fan, Hongyun Wang, Xianyin Chen, Qianyun Liu, Xiao Guo, Feiyu Gong, Li Zhou, Yu Chen
Natural evidence of coronaviral 2'-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding. Signal transduction and targeted therapy 9 (1) (2024)
Qianyun Liu, Yuchi Lu, Chenguang Cai, Yanyan Huang, Li Zhou, Yanbin Guan, Shiying Fu, Youyou Lin, Huan Yan, Zhen Zhang, Xiang Li, Xiu-Na Yang, Haitao Yang, Hangtian Guo, Ke Lan, Yu Chen, Shin-Chen Hou, Yi Xiong
A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug. Cell death & disease 15 (6) (2024)
Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan, Jiejie Liu, Yanying Yu, Qiang Ding, Chengpeng Fan, Hongyun Wang, Xianyin Chen, Qianyun Liu, Xiao Guo, Feiyu Gong, Li Zhou, Yu Chen
Natural evidence of coronaviral 2'-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding. Signal transduction and targeted therapy 9 (1) (2024)
Qianyun Liu, Yuchi Lu, Chenguang Cai, Yanyan Huang, Li Zhou, Yanbin Guan, Shiying Fu, Youyou Lin, Huan Yan, Zhen Zhang, Xiang Li, Xiu-Na Yang, Haitao Yang, Hangtian Guo, Ke Lan, Yu Chen, Shin-Chen Hou, Yi Xiong
A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug. Cell death & disease 15 (6) (2024)
Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen
The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development. Emerging microbes & infections 13 (1) (2024)
Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen
The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development. Emerging microbes & infections (2024)
Xian Li, Mengxin Xu, Jingyi Yang, Li Zhou, Lin Liu, Min Li, Shasha Wang, Mei-Qin Liu, Zhixiang Huang, Zhen Zhang, Shuning Liu, Yunqi Hu, Haofeng Lin, Bowen Liu, Ying Sun, Qingguo Wu, Zheng-Li Shi, Ke Lan, Yu Chen, Huimin Yan, Yao-Qing Chen
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1. Signal transduction and targeted therapy 9 (1) (2024)
Jiangpeng Feng, Tianmo Xu, Miao He, Jiali Li, Peipei Yao, Chengbao Ma, Shimin Yang, Zaichao Xu, Kun Yan, Xianying Chen, Hongyun Wang, Jiejie Liu, Cong Zeng, Yuchen Xia, Huan Yan, Li Zhou, Yu Chen
NSUN2-mediated m5C modification of HBV RNA positively regulates HBV replication. PLoS pathogens 19 (12) (2023)
Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan
Vaccination with S pan , an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice. Science translational medicine 15 (677) (2023)
Qianyun Liu, Haiyan Zhao, Zhiqiang Li, Zhen Zhang, Rui Huang, Mengxue Gu, Ke Zhuang, Qing Xiong, Xianying Chen, Weiyi Yu, Shengnan Qian, Yuzhen Zhang, Xue Tan, Muyi Zhang, Feiyang Yu, Ming Guo, Zhixiang Huang, Xin Wang, Wenjie Xiang, Bihao Wu, Fanghua Mei, Kun Cai, Limin Zhou, Li Zhou, Ying Wu, Huan Yan, Sheng Cao, Ke Lan, Yu Chen
Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge. Signal transduction and targeted therapy 8 (1) (2023)
Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen
NSUN2-mediated m 5 C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections. Emerging microbes & infections (2023)
Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan
Vaccination with S pan , an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice. Science translational medicine 15 (677) (2023)
Hui Fan, Li Zhou, Jingjun Lv, Shimin Yang, Guozhong Chen, Xinjin Liu, Chunyan Han, Xue Tan, Shengnan Qian, Zegang Wu, Shan Yu, Ming Guo, Chengliang Zhu, Yu Chen, Ke Lan
Bacterial coinfections contribute to severe COVID-19 in winter. Cell research (2023)
Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan
Vaccination with S pan , an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice. Science translational medicine 15 (677) (2023)
Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen
NSUN2-mediated M 5 c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections. Emerging microbes & infections 12 (1) (2023)
Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen
NSUN2-mediated M 5 c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections. Emerging microbes & infections 12 (1) (2023)
Chengbao Ma, Xianying Chen, Fanghua Mei, Qing Xiong, Qianyun Liu, Lianghui Dong, Chen Liu, Wenjing Zou, Faxian Zhan, Bing Hu, Yingle Liu, Fang Liu, Li Zhou, Junqiang Xu, Yongzhong Jiang, Ke Xu, Kun Cai, Yu Chen, Huan Yan, Ke Lan
Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerging microbes & infections 11 (1) (2022)
Qing Xiong, Lei Cao, Chengbao Ma, M Alejandra Tortorici, Chen Liu, Junyu Si, Peng Liu, Mengxue Gu, Alexandra C Walls, Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao, Chao Shen, Yu Chen, Huabin Zhao, Ke Lan, Davide Corti, David J Veesler, Xiangxi Wang, Huan Yan
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Nature (2022)
Lei Bai, Yongliang Zhao, Jiazhen Dong, Simeng Liang, Ming Guo, Xinjin Liu, Xin Wang, Zhixiang Huang, Xiaoyi Sun, Zhen Zhang, Lianghui Dong, Qianyun Liu, Yucheng Zheng, Danping Niu, Min Xiang, Kun Song, Jiajie Ye, Wenchao Zheng, Zhidong Tang, Mingliang Tang, Yu Zhou, Chao Shen, Ming Dai, Li Zhou, Yu Chen, Huan Yan, Ke Lan, Ke Xu
Coinfection with influenza A virus enhances SARS-CoV-2 infectivity. Cell research 31 (4) (2021)
Zhen Zhang, Qianyun Liu, Ying Sun, Jiali Li, Jiejie Liu, Ruangang Pan, Liu Cao, Xianying Chen, Yingjian Li, Yuzhen Zhang, Ke Xu, Deyin Guo, Li Zhou, Ke Lan, Yu Chen
Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice. Emerging microbes & infections 10 (1) (2021)
Huan Yan, Hengwu Jiao, Qianyun Liu, Zhen Zhang, Qing Xiong, Bing-Jun Wang, Xin Wang, Ming Guo, Lin-Fa Wang, Ke Lan, Yu Chen, Huabin Zhao
ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nature ecology & evolution 5 (5) (2021)
Panpan Hou, Penghui Jia, Kongxiang Yang, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chun-Mei Li, Yingfang Liu, De-Ying Guo
An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. Proceedings of the National Academy of Sciences of the United States of America 118 (3) (2021)
Yong Xiong, Yuan Liu, Liu Cao, Dehe Wang, Ming Guo, Ao Jiang, Dong Guo, Wenjia Hu, Jiayi Yang, Zhidong Tang, Honglong Wu, Yongquan Lin, Meiyuan Zhang, Qi Zhang, Mang Shi, Yingle Liu, Yu Zhou, Ke Lan, Yu Chen
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Emerging microbes & infections 9 (1) (2020)
Yuan Liu, Zhi Ning, Yu Chen, Ming Guo, Yingle Liu, Nirmal Kumar Gali, Li Sun, Yusen Duan, Jing Cai, Dane Westerdahl, Xinjin Liu, Ke Xu, Kin Fai Ho, Haidong Kan, Qingyan Fu, Ke Lan
Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals. Nature 582 (7813) (2020)
Liangjun Chen, Weiyong Liu, Qi Zhang, Ke Xu, Guangming Ye, Weichen Wu, Ziyong Sun, Fang Liu, Kailang Wu, Bo Zhong, Yi Mei, Wenxia Zhang, Yu Chen, Yirong Li, Mang Shi, Ke Lan, Yingle Liu
RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. Emerging microbes & infections 9 (1) (2020)
Tao Suo, Xinjin Liu, Jiangpeng Feng, Ming Guo, Wenjia Hu, Dong Guo, Hafiz Ullah, Yang Yang, Qiuhan Zhang, Xin Wang, Muhanmmad Sajid, Zhixiang Huang, Liping Deng, Tielong Chen, Fang Liu, Ke Xu, Yuan Liu, Qi Zhang, Yingle Liu, Yong Xiong, Guozhong Chen, Ke Lan, Yu Chen
ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens. Emerging microbes & infections 9 (1) (2020)
Xinjin Liu, Jiangpeng Feng, Qiuhan Zhang, Dong Guo, Lu Zhang, Tao Suo, Wenjia Hu, Ming Guo, Xin Wang, Zhixiang Huang, Yong Xiong, Guozhong Chen, Yu Chen, Ke Lan
Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets. Emerging microbes & infections 9 (1) (2020)
Nian Xiang, Miao He, Musarat Ishaq, Yu Gao, Feifei Song, Liang Guo, Li Ma, Guihong Sun, Dan Liu, Deyin Guo, Yu Chen
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription. PloS one 11 (10) (2016)

Yu Chen.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Yu Chen