Zheng-Jian Li (Zhengjian Li, Zheng Jian Li, Z J Li, Zheng J Li, Zheng Jian Li)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 46

Top Venues

Biotechnology and bioengineering

mAbs

Biotechnology journal

Biotechnology progress

Bristol-Myers Squibb Co

University of Maryland Baltimore County (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Bristol-Myers Squibb Co

United States

Head :: Late Stage Biologics Development

Entremed Inc - Aug 08 2002

United States

Fermentation Scientist/ scientist I & II :: Cell & Molecular Biology

Education History

University of Maryland Baltimore County

United States

PHD :: Chemical and Biochemcial Engineering

Tsinghua University Aug 17 1987 - Aug 15 1992

China

BSC :: Chemical Engineering & Applied Physics

Publications

Jing Zhen, Jennifer Lee, Yueyang Wang, Lena McLaughlin, Fei Yang, Zheng-Jian Li, Xiangyang Wang
Characterization of N-Terminal Asparagine Deamidation and Clipping of a Monoclonal Antibody. Antibodies (Basel, Switzerland) 12 (3) (2023)
Qin He, Matthew S Rehmann, Jun Tian, Jianlin Xu, Luzmary Sabino, Erik Vandermark, Ziev Basson, Iris Po, Kathleen Bierilo, Gabi Tremml, Giovanni Rizzi, Erik F Langsdorf, Nan-Xin Qian, Michael C Borys, Anurag Khetan, Zheng-Jian Li
Improved Titer in Late-Stage Mammalian Cell Culture Manufacturing by Re-Cloning. Bioengineering (Basel, Switzerland) 9 (4) (2022)
Seo-Young Park, Susan Egan, Anthony J Cura, Kathryn L Aron, Xuankuo Xu, Mengyuan Zheng, Michael Borys, Sanchayita Ghose, Zheng-Jian Li, Kyongbum Lee
Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction. mAbs 13 (1) (2022)
Hasin Feroz, Naresh Chennamsetty, Sara Byers, Melissa Holstein, Zheng-Jian Li, Sanchayita Ghose
Assessing detergent-mediated virus inactivation, protein stability, and impurity clearance in biologics downstream processes. Biotechnology and bioengineering 119 (4) (2022)
Emily S C Rittershaus, Matthew S Rehmann, Jianlin Xu, Qin He, Charles Hill, Jeffrey Swanberg, Michael C Borys, Zheng-Jian Li, Anurag Khetan
N-1 Perfusion Platform Development Using a Capacitance Probe for Biomanufacturing. Bioengineering (Basel, Switzerland) 9 (4) (2022)
Jianlin Xu, Johanna Santos, Nadine S Anderson, Michael C Borys, Girish Pendse, Zheng-Jian Li
Antibody charge variant modulation by in vitro enzymatic treatment in different Chinese hamster ovary cell cultures. Biotechnology progress 38 (5) (2022)
James M Angelo, Kevin Potter, Thomas Müller-Späth, Xuankuo Xu, Zheng-Jian Li, Sanchayita Ghose
Continued insights into virus clearance validation across continuous capture chromatography. Biotechnology and bioengineering 118 (9) (2021)
Grace Yao, Kathryn Aron, Michael Borys, Zheng-Jian Li, Girish Pendse, Kyongbum Lee
A Metabolomics Approach to Increasing Chinese Hamster Ovary (CHO) Cell Productivity. Metabolites 11 (12) (2021)
Peifeng Tang, Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Laurel Hoffman, Cheng Du, Yuanli Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Zheng-Jian Li, Shijie Liu
Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses. mAbs 12 (1) (2021)
Pratik U Joshi, Christa L Meingast, Xuankuo Xu, Melissa Holstein, Hasin Feroz, Swarnim Ranjan, Sanchayita Ghose, Zheng-Jian Li, Caryn L Heidt
Virus Inactivation at Moderately Low pH Varies with Virus and Buffer Properties. Biotechnology journal (2021)
Jianlin Xu, Shun Zheng, Zeinab Dawood, Charles Hill, Weixin Jin, Xuankuo Xu, Julia Ding, Michael C Borys, Sanchayita Ghose, Zheng-Jian Li, Girish Pendse
Productivity improvement and charge variant modulation for intensified cell culture processes by adding a carboxypeptidase B (CpB) treatment step. Biotechnology and bioengineering 118 (9) (2021)
Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng-Jian Li, Shijie Liu
On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies. mAbs 12 (1) (2021)
Tingwei Ren, Zhijun Tan, Vivekh Ehamparanathan, Angela Lewandowski, Sanchayita Ghose, Zheng-Jian Li
Antibody disulfide bond reduction and recovery during biopharmaceutical process development-A review. Biotechnology and bioengineering 118 (8) (2021)
Hasin Feroz, Daniel Cetnar, Robert Hewlett, Satish Sharma, Melissa Holstein, Sanchayita Ghose, Zheng-Jian Li
Surrogate model to screen for inactivation-based clearance of enveloped viruses during biotherapeutics process development. Biotechnology journal 16 (12) (2021)
Christa L Meingast, Pratik U Joshi, Dylan G Turpeinen, Xuankuo Xu, Melissa Holstein, Hasin Feroz, Swarnim Ranjan, Sanchayita Ghose, Zheng-Jian Li, Caryn L Heidt
Physiochemical properties of enveloped viruses and arginine dictate inactivation. Biotechnology journal 16 (7) (2021)
Jay M West, Hasin Feroz, Xia Xu, Neha Puri, Melissa Holstein, Sanchayita Ghose, Julia Ding, Zheng-Jian Li
Process analytical technology for on-line monitoring of quality attributes during single-use ultrafiltration/diafiltration. Biotechnology and bioengineering 118 (6) (2021)
Zhiqiang Chen, Yueming Qian, Yuanli Song, Xuankuo Xu, Li Tao, Nesredin Mussa, Sanchayita Ghose, Zheng-Jian Li
Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics. mAbs 12 (1) (2021)
Letha Chemmalil, Dhanuka P Wasalathanthri, Xin Zhang, June Kuang, Chun Shao, Robin Barbour, Sohil Bhavsar, Tanushree Prabhakar, Ryan Knihtila, Jay West, Neha Puri, Kyle McHugh, Matthew S Rehmann, Qin He, Jianlin Xu, Michael C Borys, Julia Ding, Zheng-Jian Li
Online monitoring and control of upstream cell culture process using 1D and 2D-LC with SegFlow interface. Biotechnology and bioengineering 118 (9) (2021)
Jianlin Xu, Xuankuo Xu, Chao Huang, James M Angelo, Christopher L Oliveira, Mengmeng Xu, Xia Xu, Deniz Temel, Julia Ding, Sanchayita Ghose, Michael C Borys, Zheng-Jian Li
Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study. mAbs 12 (1) (2020)
Dhanuka P Wasalathanthri, Hasin Feroz, Neha Puri, Jessica Hung, Gregory Lane, Melissa Holstein, Letha Chemmalil, Douglas Both, Sanchayita Ghose, Julia Ding, Zheng-Jian Li
Real-time monitoring of quality attributes by in-line Fourier transform infrared spectroscopic sensors at ultrafiltration and diafiltration of bioprocess. Biotechnology and bioengineering 117 (12) (2020)
Jun Tian, Qin He, Christopher Oliveira, Yueming Qian, Susan Egan, Jianlin Xu, Nan-Xin Qian, Erik Langsdorf, Bethanne Warrack, Nelly Aranibar, Michael Reily, Michael Borys, Zheng-Jian Li
Increased MSX level improves biological productivity and production stability in multiple recombinant GS CHO cell lines. Engineering in life sciences 20 (3-4) (2020)
Zizhuo Xing, Weixin Jin, Xuankuo Xu, Yuanli Song, Chao Huang, Michael C Borys, Sanchayita Ghose, Zheng-Jian Li
A CFD model for predicting protein aggregation in low-pH virial inactivation for mAb production. Biotechnology and bioengineering 117 (11) (2020)
Yi Li, Lye Lin Lock, Jason Mills, Ben S Ou, Marina Morrow, David Stern, Han Wang, Caleb F Anderson, Xuankuo Xu, Sanchayita Ghose, Zheng-Jian Li, Honggang Cui
Selective Capture and Recovery of Monoclonal Antibodies by Self-Assembling Supramolecular Polymers of High Affinity for Protein Binding. Nano letters 20 (10) (2020)
Qian Guan, Jennifer Atsma, Rekha Tulsan, Sergey Voronov, Julia Ding, Jeff Beckman, Zheng-Jian Li
Minimization of artifact protein aggregation using tetradecyl sulfate and hexadecyl sulfate in capillary gel electrophoresis under reducing conditions. Electrophoresis 41 (13-14) (2020)
Xin Zhang, Letha Chemmalil, Julia Ding, Zheng-Jian Li
A novel approach enables imaged capillary isoelectric focusing analysis of PEGylated proteins. Electrophoresis 41 (9) (2020)
Peifeng Tang, Jianlin Xu, Alastair Louey, Zhijun Tan, Andrew Yongky, Shaoyan Liang, Zheng-Jian Li, Yongyan Weng, Shijie Liu
Kinetic modeling of Chinese hamster ovary cell culture: factors and principles. Critical reviews in biotechnology 40 (2) (2020)
Melissa Holstein, Jessica Hung, Hasin Feroz, Swarnim Ranjan, Cheng Du, Sanchayita Ghose, Zheng-Jian Li
Strategies for high-concentration drug substance manufacturing to facilitate subcutaneous administration: A review. Biotechnology and bioengineering 117 (11) (2020)
Melissa Holstein, Dongyoun Jang, Christine Urrea, Lakshmi Sirisha Botta, William Grimm, Sanchayita Ghose, Zheng-Jian Li
Control of leached beta-glucan levels from depth filters by an improved depth filtration flush strategy. Biotechnology progress 37 (1) (2020)
Dhanuka P Wasalathanthri, Matthew S Rehmann, Yuanli Song, Yan Gu, Luo Mi, Chun Shao, Letha Chemmalil, Jongchan Lee, Sanchayita Ghose, Michael C Borys, Julia Ding, Zheng-Jian Li
Technology outlook for real-time quality attribute and process parameter monitoring in biopharmaceutical development-A review. Biotechnology and bioengineering 117 (10) (2020)
Weixin Jin, Zizhuo Xing, Yuanli Song, Chao Huang, Xuankuo Xu, Sanchayita Ghose, Zheng-Jian Li
Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification. mAbs 11 (8) (2019)
Stanley Chung, Jun Tian, Zhijun Tan, Jie Chen, Na Zhang, Yunping Huang, Erik Vandermark, Jongchan Lee, Michael Borys, Zheng-Jian Li
Modulating cell culture oxidative stress reduces protein glycation and acidic charge variant formation. mAbs 11 (1) (2019)
Andrew Yongky, Jianlin Xu, Jun Tian, Christopher Oliveira, Jia Zhao, Kevin S McFarland, Michael C Borys, Zheng-Jian Li
Process intensification in fed-batch production bioreactors using non-perfusion seed cultures. mAbs 11 (8) (2019)
Ruben Wälchli, Mariana Ressurreição, Sebastian Vogg, Fabian Feidl, James M Angelo, Xuankuo Xu, Sanchayita Ghose, Zheng-Jian Li, Xavier Le Saoût, Jonathan Souquet, Hervé Broly, Massimo Morbidelli
Understanding mAb aggregation during low pH viral inactivation and subsequent neutralization. Biotechnology and bioengineering 117 (3) (2019)
Daniel Baur, James M Angelo, Srinivas Chollangi, Thomas Müller-Späth, Xuankuo Xu, Sanchayita Ghose, Zheng-Jian Li, Massimo Morbidelli
Model-assisted process characterization and validation for a continuous two-column protein A capture process. Biotechnology and bioengineering 116 (1) (2018)
Yueming Qian, Zhiqiang Chen, Xin Huang, Xuning Wang, Xuankuo Xu, Stefan Kirov, Richard Ludwig, Nan-Xin Qian, Kandasamy Ravi, Li Tao, Michael C Borys, Zheng-Jian Li
Early identification of unusually clustered mutations and root causes in therapeutic antibody development. Biotechnology and bioengineering 115 (9) (2018)
Yueming Qian, Matthew S Rehmann, Nan-Xin Qian, Aiqing He, Michael C Borys, Paul S Kayne, Zheng-Jian Li
Hypoxia and transforming growth factor-beta1 pathway activation promote Chinese Hamster Ovary cell aggregation. Biotechnology and bioengineering 115 (4) (2018)
Andrew R Swartz, Xuankuo Xu, Steven J Traylor, Zheng-Jian Li, Wilfred Chen
High-efficiency affinity precipitation of multiple industrial mAbs and Fc-fusion proteins from cell culture harvests using Z-ELP-E2 nanocages. Biotechnology and bioengineering 115 (8) (2018)
Jianlin Xu, Matthew S Rehmann, Xuankuo Xu, Chao Huang, Jun Tian, Nan-Xin Qian, Zheng-Jian Li
Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media. mAbs 10 (3) (2018)
Jeff Beckman, Yuanli Song, Yan Gu, Sergey Voronov, Naresh Chennamsetty, Stanley Krystek, Nesredin Mussa, Zheng-Jian Li
Purity Determination by Capillary Electrophoresis Sodium Hexadecyl Sulfate (CE-SHS): A Novel Application For Therapeutic Protein Characterization. Analytical chemistry 90 (4) (2018)
Daniel G Greene, Steven J Traylor, Jing Guo, Leila H Choe, Shannon Modla, Xuankuo Xu, Nripen Singh, Lye Lin Lock, Sanchayita Ghose, Zheng-Jian Li, Kelvin H Lee, Norman J Wagner, Abraham M Lenhoff
Mechanisms of precipitate formation during the purification of an Fc-fusion protein. Biotechnology and bioengineering 115 (10) (2018)
Jianlin Xu, Peifeng Tang, Andrew Yongky, Barry Drew, Michael C Borys, Shijie Liu, Zheng-Jian Li
Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling. mAbs 11 (1) (2018)
Ohnmar Khanal, Nripen Singh, Steven J Traylor, Xuankuo Xu, Sanchayita Ghose, Zheng-Jian Li, Abraham M Lenhoff
Contributions of depth filter components to protein adsorption in bioprocessing. Biotechnology and bioengineering 115 (8) (2018)
Stanley Chung, Jun Tian, Zhijun Tan, Jie Chen, Jongchan Lee, Michael Borys, Zheng-Jian Li
Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles. Biotechnology and bioengineering 115 (7) (2018)
Youngbin Baek, Nripen Singh, Abhiram Arunkumar, Michael Borys, Zheng-Jian Li, Andrew L Zydney
Ultrafiltration behavior of monoclonal antibodies and Fc-fusion proteins: Effects of physical properties. Biotechnology and bioengineering 114 (9) (2017)
Andrew R Swartz, Xuankuo Xu, Steven J Traylor, Zheng-Jian Li, Wilfred Chen
One-step affinity capture and precipitation for improved purification of an industrial monoclonal antibody using Z-ELP functionalized nanocages. Biotechnology and bioengineering 115 (2) (2017)
Cheng Du, Robert Martin, Yunping Huang, Ameya Borwankar, Zhijun Tan, Jay West, Nripen Singh, Michael Borys, Sanchayita Ghose, Richard Ludwig, Li Tao, Zheng-Jian Li
Vitamin B12 association with mAbs: Mechanism and potential mitigation strategies. Biotechnology and bioengineering 115 (4) (2017)

Zheng-Jian Li.css-eqlu8i{font-size:small;padding-left:4px;} (Zhengjian Li, Zheng Jian Li, Z J Li, Zheng J Li, Zheng Jian Li)

Publication Activity (10 Years)

Top Topics

Top Venues

Zheng-Jian Li (Zhengjian Li, Zheng Jian Li, Z J Li, Zheng J Li, Zheng Jian Li)