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Zheng Ruan

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 25

Top Venues

eLife

Proceedings of the National Academy of Sciences of the United States of America

Nature

Science signaling

Van Andel Research Institute

Huazhong Agriculture University (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Van Andel Research Institute Aug 21o 2018

United States

Postdoctoral Fellow :: Structural Biology

Education History

Huazhong Agriculture University Sep 1o 2008 - Jun 1o 2012

China

BSC :: College of Life Science and Technology

Publications

Ljubica Mihaljevic, Zheng Ruan, James Osei-Owusu, Wei Lü, Zhaozhu Qiu
Inhibition of the proton-activated chloride channel PAC by PIP 2 . eLife 12 (2023)
Ljubica Mihaljević, Zheng Ruan, James Osei-Owusu, Wei Lü, Zhaozhu Qiu
Inhibition of the proton-activated chloride channel PAC by PIP 2 . eLife 12 (2023)
Ljubica Mihaljević, Zheng Ruan, James Osei-Owusu, Wei Lü, Zhaozhu Qiu
Inhibition of the proton-activated chloride channel PAC by PIP 2 . eLife 12 (2023)
Ljubica Mihaljević, Zheng Ruan, James Osei-Owusu, Wei Lü, Zhaozhu Qiu
Inhibition of the proton-activated chloride channel PAC by PIP 2 . eLife 12 (2023)
Ljubica Mihaljević, Zheng Ruan, James Osei-Owusu, Wei Lü, Zhaozhu Qiu
Inhibition of the proton-activated chloride channel PAC by PIP 2 . eLife 12 (2023)
Ljubica Mihaljević, Zheng Ruan, James Osei-Owusu, Wei Lü, Zhaozhu Qiu
Inhibition of the proton-activated chloride channel PAC by PIP 2 . eLife 12 (2023)
Ljubica Mihaljević, Zheng Ruan, James Osei-Owusu, Wei Lü, Zhaozhu Qiu
Inhibition of the proton-activated chloride channel PAC by PIP 2 . eLife 12 (2023)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
James Osei-Owusu, Ekaterina Kots, Zheng Ruan, Ljubica Mihaljević, Kevin Hong Chen, Ami Tamhaney, Xinyu Ye, Wei Lü, Harel Weinstein, Zhaozhu Qiu
Molecular determinants of pH sensing in the proton-activated chloride channel. Proceedings of the National Academy of Sciences of the United States of America 119 (31) (2022)
James Osei-Owusu, Zheng Ruan, Ljubica Mihaljević, Daniel S Matasic, Kevin Hong Chen, Wei Lü, Zhaozhu Qiu
Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC. eLife 11 (2022)
Zheng Ruan, Emery Haley, Ian J Orozco, Mark Sabat, Richard Myers, Rebecca Roth, Juan Du, Wei Lü
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nature structural & molecular biology 28 (7) (2021)
Zheng Ruan, Ian J Orozco, Juan Du, Wei Lü
Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature 584 (7822) (2020)
Zheng Ruan, James Osei-Owusu, Juan Du, Zhaozhu Qiu, Wei Lü
Structures and pH-sensing mechanism of the proton-activated chloride channel. Nature 588 (7837) (2020)
Yu-Yang Jiang, Wolfgang Maier, Ralf Baumeister, Gregory Minevich, Ewa Joachimiak, Dorota Wloga, Zheng Ruan, Natarajan Kannan, Stephen Bocarro, Anoosh Bahraini, Krishna Kumar Vasudevan, Karl-Ferdinand Lechtreck, Eduardo Orias, Jacek Gaertig
LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena. PLoS genetics 15 (7) (2019)
Liang-Chin Huang, Karen E Ross, Timothy R Baffi, Harold Drabkin, Krzysztof J Kochut, Zheng Ruan, Peter D'Eustachio, Daniel McSkimming, Cecilia Arighi, Chuming Chen, Darren A Natale, Cynthia L Smith, Pascale Gaudet, Alexandra C Newton, Cathy Wu, Natarajan Kannan
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources. Scientific reports 8 (1) (2018)
Zheng Ruan, Natarajan Kannan
Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC-β4 loop insertion mutations. Proceedings of the National Academy of Sciences of the United States of America 115 (35) (2018)
Yu-Yang Jiang, Wolfgang Maier, Ralf Baumeister, Ewa Joachimiak, Zheng Ruan, Natarajan Kannan, Diamond Clarke, Panagiota Louka, Mayukh Guha, Joseph Frankel, Jacek Gaertig
Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the Ciliate Tetrahymena. Genetics 211 (2) (2018)
Sam A Jamieson, Zheng Ruan, Abigail E Burgess, Jack R Curry, Hamish D McMillan, Jodi L Brewster, Anita K Dunbier, Alison D Axtman, Natarajan Kannan, Peter D Mace
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Science signaling 11 (549) (2018)
Zheng Ruan, Samiksha Katiyar, Natarajan Kannan
Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase. Biochemistry 56 (1) (2016)

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Publication Activity (10 Years)

Top Topics

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Zheng Ruan