Alison D Axtman

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 62

Top Topics

Amyotrophic Lateral Sclerosis

Tyrosine Kinase

Top Venues

bioRxiv : the preprint server for biology

ACS chemical neuroscience

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot Singh Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. bioRxiv : the preprint server for biology (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck, Sabrina C D Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B Robers, Alison D Axtman, Frances M Bashore
Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants. bioRxiv : the preprint server for biology (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot Singh Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. bioRxiv : the preprint server for biology (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2. Molecules (Basel, Switzerland) 29 (17) (2024)
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, Charles A Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, null null, Alison D Axtman
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. PloS one 19 (2) (2024)
Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck, Sabrina C D Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B Robers, Alison D Axtman, Frances M Bashore
Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants. bioRxiv : the preprint server for biology (2024)
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, Charles A Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, null null, Alison D Axtman
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. PloS one 19 (2) (2024)
Jacob L Capener, James D Vasta, Vittorio L Katis, Ani Michaud, Michael T Beck, Sabrina C D Daglish, Sarit Cohen-Kedar, Efrat Shaham Barda, Stefanie Howell, Iris Dotan, Matthew B Robers, Alison D Axtman, Frances M Bashore
Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants. bioRxiv : the preprint server for biology (2024)
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, Charles A Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, null null, Alison D Axtman
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. PloS one 19 (2) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot Singh Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. bioRxiv : the preprint server for biology (2024)
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, Charles A Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, null null, Alison D Axtman
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. PloS one 19 (2) (2024)
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, Charles A Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, null null, Alison D Axtman
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. PloS one 19 (2) (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry (2024)
Frances M Bashore, Sophia M Min, Xiangrong Chen, Stefanie Howell, Caroline H Rinderle, Gabriel Morel, Josie A Silvaroli, Carrow I Wells, Bruce A Bunnell, David Harold Drewry, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, Alison D Axtman
Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2. ACS medicinal chemistry letters 15 (8) (2024)
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, Charles A Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, null null, Alison D Axtman
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. PloS one 19 (2) (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Han Wee Ong, Yi Liang, William Richardson, Josie A Silvaroli, Frances M Bashore, Jeffery L Smith, Isabelle M Genereux, Kelvin Dempster, David H Drewry, Navjot S Pabla, Alex N Bullock, Timothy A Benke, Sila K Ultanir, Alison D Axtman
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Frances M Bashore, Ariana B Marquez, Apirat Chaikuad, Stefanie Howell, Andrea S Dunn, Alvaro A Beltran, Jeffery L Smith, David Harold Drewry, Adriana S Beltran, Alison D Axtman
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Scientific reports 13 (1) (2023)
Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, William Tao, Edcon Chang, Nathaniel J Moorman, Alison D Axtman, Timothy M Willson
Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5- a ]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A. ACS omega 8 (42) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Frances M Bashore, Joel K Annor-Gyamfi, Yuhong Du, Vittorio Katis, Felix Nwogbo, Raymond G Flax, Stephen V Frye, Kenneth H Pearce, Haian Fu, Timothy M Willson, David Harold Drewry, Alison D Axtman
Fused Tetrahydroquinolines Are Interfering with Your Assay. Journal of medicinal chemistry (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, William Tao, Edcon Chang, Nathaniel J Moorman, Alison D Axtman, Timothy M Willson
Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Yuhong Du, William J Bradshaw, Tina M Leisner, Joel K Annor-Gyamfi, Kun Qian, Frances M Bashore, Arunima Sikdar, Felix O Nwogbo, Andrey A Ivanov, Stephen V Frye, Opher Gileadi, Paul E Brennan, Allan I Levey, null null, Alison D Axtman, Kenneth H Pearce, Haian Fu, Vittorio L Katis
Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience 14 (9) (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David H Drewry, Alison D Axtman
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David H Drewry, Alison D Axtman
A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective. bioRxiv : the preprint server for biology (2023)
Zachary W Davis-Gilbert, Andreas Krämer, James E Dunford, Stefanie Howell, Filiz Senbabaoglu, Carrow I Wells, Frances M Bashore, Tammy M Havener, Jeffery L Smith, Mohammad Anwar Hossain, Udo Oppermann, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2. ACS medicinal chemistry letters 14 (4) (2023)
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, Andrew C Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Veronica F Hinman, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, null null, Alison D Axtman
Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM. bioRxiv : the preprint server for biology (2023)
Anna Castano, Margaux Silvestre, Carrow I Wells, Jennifer L Sanderson, Carla A Ferrer, Han Wee Ong, Yi Liang, William Richardson, Josie A Silvaroli, Frances M Bashore, Jeffery L Smith, Isabelle M Genereux, Kelvin Dempster, David H Drewry, Navjot S Pabla, Alex N Bullock, Timothy A Benke, Sila K Ultanir, Alison D Axtman
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. bioRxiv : the preprint server for biology (2023)
Han Wee Ong, Yi Liang, William Richardson, Emily R Lowry, Carrow I Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A Silvaroli, Jeffery L Smith, Hynek Wichterle, Navjot S Pabla, Sila K Ultanir, Alex N Bullock, David Harold Drewry, Alison D Axtman
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS chemical neuroscience (2023)
David Harold Drewry, Frances M Bashore, Armin Bayati, Jeffery L Smith, Rebekah J Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M Min, Mohammad Anwar Hossain, Mark Heise, Peter S McPherson, Nathaniel J Moorman, Alison D Axtman
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses. Journal of medicinal chemistry 65 (19) (2022)
Frances M Potjewyd, Joel K Annor-Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L Conlon, Kevin J Frankowski, Shiva K R Guduru, Brian P Hardy, Megan D Hopkins, Chizuru Kinoshita, Dmitri B Kireev, Emily R Mason, Charles T Moerk, Felix Nwogbo, Kenneth H Pearce, Timothy I Richardson, David A Rogers, Disha M Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M Willson, Stephen V Frye, Jessica E Young, Alison D Axtman
AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery. Alzheimer's & dementia (New York, N. Y.) 8 (1) (2022)
Frances M Potjewyd, Joel K Annor-Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L Conlon, Kevin J Frankowski, Shiva K R Guduru, Brian P Hardy, Megan D Hopkins, Chizuru Kinoshita, Dmitri B Kireev, Emily R Mason, Charles T Moerk, Felix Nwogbo, Kenneth H Pearce, Timothy I Richardson, David A Rogers, Disha M Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M Willson, Stephen V Frye, Jessica E Young, Alison D Axtman
Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology. Alzheimer's & dementia (New York, N. Y.) 8 (1) (2022)
Xuan Yang, Rebekah J Dickmander, Armin Bayati, Sharon A Taft-Benz, Jeffery L Smith, Carrow I Wells, Emily A Madden, Jason W Brown, Erik M Lenarcic, Boyd L Yount, Edcon Chang, Alison D Axtman, Ralph S Baric, Mark T Heise, Peter S McPherson, Nathaniel J Moorman, Timothy M Willson
Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses. ACS chemical biology 17 (7) (2022)
Carrow I Wells, Hassan Al-Ali, David M Andrews, Christopher R M Asquith, Alison D Axtman, Ivan Dikic, Daniel V Ebner, Peter Ettmayer, Christian Fischer, Mathias Frederiksen, Robert E Futrell, Nathanael S Gray, Stephanie B Hatch, Stefan Knapp, Ulrich Lücking, Michael Michaelides, Caitlin E Mills, Susanne Müller, Dafydd Owen, Alfredo Picado, Kumar S Saikatendu, Martin Schröder, Alexandra Stolz, Mariana Tellechea, Brandon J Turunen, Santiago Vilar, Jinhua Wang, William J Zuercher, Timothy M Willson, David Harold Drewry
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification. International journal of molecular sciences 22 (2) (2021)
Dennis C Liotta, Alison D Axtman
NeuroChat with Research Assistant Professor Alison Axtman. ACS chemical neuroscience 11 (18) (2021)
David Harold Drewry, Joel K Annor-Gyamfi, Carrow I Wells, Julie E Pickett, Verena Dederer, Franziska Preuss, Sebastian Mathea, Alison D Axtman
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration. Journal of medicinal chemistry (2021)
Tigist Y Tamir, David Harold Drewry, Carrow I Wells, Michael B Major, Alison D Axtman
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor. Scientific reports 10 (1) (2020)
Andrea I Krahn, Carrow I Wells, David Harold Drewry, Lenore K Beitel, Thomas M Durcan, Alison D Axtman
Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases. ACS chemical neuroscience 11 (13) (2020)
Christopher B Wang, Álvaro Lorente-Macías, Carrow I Wells, Julie E Pickett, Alfredo Picado, William J Zuercher, Alison D Axtman
Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series. RSC medicinal chemistry 12 (1) (2020)
Sam A Jamieson, Zheng Ruan, Abigail E Burgess, Jack R Curry, Hamish D McMillan, Jodi L Brewster, Anita K Dunbier, Alison D Axtman, Natarajan Kannan, Peter D Mace
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1. Science signaling 11 (549) (2018)