Altered fatty acid-binding protein 4 (FABP4) expression and function in human and animal models of hepatocellular carcinoma.
Kyle J ThompsonRebecca Garland AustinShayan S NazariKeith S GersinDavid A IannittiIain H McKillopPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
These data suggest FABP4, an FABP not normally expressed in the liver, can be synthesized and secreted by hepatocytes and HCC cells, and that FABP4 may play a role in regulating tumour progression in the underlying setting of obesity.
Keyphrases
- binding protein
- fatty acid
- induced apoptosis
- endothelial cells
- metabolic syndrome
- type diabetes
- weight loss
- insulin resistance
- cell cycle arrest
- poor prognosis
- oxidative stress
- big data
- skeletal muscle
- cell death
- signaling pathway
- machine learning
- adipose tissue
- cell proliferation
- pluripotent stem cells
- deep learning
- pi k akt