Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription.

John PangNam-Phuong Nguyen Jens LuebeckLaurel BallAndrey FinegershShuling RenTakuya NakagawaMitchell FlaggSayed SadatPaul S MischelGuorong XuKathleen M Fisch Theresa W GuoGabrielle CahillBharat PanugantiVineet BafnaJoseph Califano

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Nonchromosomal circular oncogenic DNA is a dominant feature of HPVOPC, revealing an unanticipated link between HPV and ecDNA that leverages the power of extrachromosomal inheritance to drive HPV and somatic oncogene expression.

Keyphrases

high grade
circulating tumor
cell free
single molecule
poor prognosis
cervical cancer screening
transcription factor
papillary thyroid
machine learning
mitochondrial dna
copy number
nucleic acid
deep learning
binding protein
dna methylation
long non coding rna
childhood cancer
circulating tumor cells