Paul S Mischel (Paul Mischel)

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 34

Top Topics

Gene Expression

Top Venues

Nature reviews. Cancer

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer 24 (4) (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer (2024)
Joseph Califano, Takuya Nakagawa, Jens Luebeck, Kaiyuan Zhu, Joshua T Lange, Roman Sasik, Chad Phillips, Sayed Sadat, Sara Javadzadeh, Qian Yang, Allen Wang, Kersi Pestonjamasp, Sara Rosenthal, Kathleen M Fisch, Paul S Mischel, Vineet Bafna
Inhibition of novel human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer. Research square (2024)
John C Rose, Julia A Belk, Ivy Tsz-Lo Wong, Jens Luebeck, Hudson T Horn, Bence Daniel, Matthew G Jones, Kathryn E Yost, King L Hung, Kevin S Kolahi, Ellis J Curtis, Calvin J Kuo, Vineet Bafna, Paul S Mischel, Howard Y Chang
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair. Cancer discovery (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer 24 (4) (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer 24 (4) (2024)
John C Rose, Julia A Belk, Ivy Tsz-Lo Wong, Jens Luebeck, Hudson T Horn, Bence Daniel, Matthew G Jones, Kathryn E Yost, King L Hung, Kevin S Kolahi, Ellis J Curtis, Calvin J Kuo, Vineet Bafna, Paul S Mischel, Howard Y Chang
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair. Cancer discovery (2024)
Jens Luebeck, Alvin Wei Tian Ng, Patricia C Galipeau, Xiaohong Li, Carissa A Sanchez, Annalise C Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott M Lippman, Roel G W Verhaak, Carlo C Maley, Ludmil B Alexandrov, Brian J Reid, Rebecca C Fitzgerald, Thomas G Paulson, Howard Y Chang, Sihan Wu, Vineet Bafna, Paul S Mischel
Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. Nature (2023)
Albert S Agustinus, Duaa H Al-Rawi, Bhargavi Dameracharla, Ramya Raviram, Bailey S C L Jones, Stephanie Stransky, Lorenzo Scipioni, Jens Luebeck, Melody DiBona, Danguole Norkunaite, Robert M Myers, Mercedes Duran, Seongmin Choi, Jorge S Reis-Filho, Shira Yomtoubian, Andrew McPherson, Eléonore Toufektchan, Kristina Keuper, Paul S Mischel, Vivek Mittal, Sohrab P Shah, John Maciejowski, Zuzana Storchová, Enrico Gratton, Peter Ly, Dan Landau, Mathieu F Bakhoum, Richard P Koche, Simone Sidoli, Vineet Bafna, Yael David, Samuel F Bakhoum
Epigenetic dysregulation from chromosomal transit in micronuclei. Nature (2023)
Ramya Raviram, Anugraha Raman, Sebastian Preissl, Jiangfang Ning, Shaoping Wu, Tomoyuki Koga, Kai Zhang, Cameron W Brennan, Chenxu Zhu, Jens Luebeck, Kinsey Van Deynze, Jee Yun Han, Xiaomeng Hou, Zhen Ye, Anna K Mischel, Yang Eric Li, Rongxin Fang, Tomas Baback, Joshua Mugford, Claudia Z Han, Christopher K Glass, Cathy L Barr, Paul S Mischel, Vineet Bafna, Laure Escoubet, Bing Ren, Clark C Chen
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Ramya Raviram, Anugraha Raman, Sebastian Preissl, Jiangfang Ning, Shaoping Wu, Tomoyuki Koga, Kai Zhang, Cameron W Brennan, Chenxu Zhu, Jens Luebeck, Kinsey Van Deynze, Jee Yun Han, Xiaomeng Hou, Zhen Ye, Anna K Mischel, Yang Eric Li, Rongxin Fang, Tomas Baback, Joshua Mugford, Claudia Z Han, Christopher K Glass, Cathy L Barr, Paul S Mischel, Vineet Bafna, Laure Escoubet, Bing Ren, Clark C Chen
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Ramya Raviram, Anugraha Raman, Sebastian Preissl, Jiangfang Ning, Shaoping Wu, Tomoyuki Koga, Kai Zhang, Cameron W Brennan, Chenxu Zhu, Jens Luebeck, Kinsey Van Deynze, Jee Yun Han, Xiaomeng Hou, Zhen Ye, Anna K Mischel, Yang Eric Li, Rongxin Fang, Tomas Baback, Joshua Mugford, Claudia Z Han, Christopher K Glass, Cathy L Barr, Paul S Mischel, Vineet Bafna, Laure Escoubet, Bing Ren, Clark C Chen
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Ramya Raviram, Anugraha Raman, Sebastian Preissl, Jiangfang Ning, Shaoping Wu, Tomoyuki Koga, Kai Zhang, Cameron W Brennan, Chenxu Zhu, Jens Luebeck, Kinsey Van Deynze, Jee Yun Han, Xiaomeng Hou, Zhen Ye, Anna K Mischel, Yang Eric Li, Rongxin Fang, Tomas Baback, Joshua Mugford, Claudia Z Han, Christopher K Glass, Cathy L Barr, Paul S Mischel, Vineet Bafna, Laure Escoubet, Bing Ren, Clark C Chen
Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Owen S Chapman, Jens Luebeck, Sunita Sridhar, Ivy Tsz-Lo Wong, Deobrat Dixit, Shanqing Wang, Gino Prasad, Utkrisht Rajkumar, Meghana S Pagadala, Jon D Larson, Britney Jiayu He, King L Hung, Joshua T Lange, Siavash R Dehkordi, Sahaana Chandran, Miriam Adam, Ling Morgan, Sameena Wani, Ashutosh Tiwari, Caitlin Guccione, Yingxi Lin, Aditi Dutta, Yan Yuen Lo, Edwin Juarez, James T Robinson, Andrey Korshunov, John-Edward A Michaels, Yoon-Jae Cho, Denise M Malicki, Nicole G Coufal, Michael L Levy, Charlotte Hobbs, Richard H Scheuermann, John R Crawford, Scott L Pomeroy, Jeremy N Rich, Xinlian Zhang, Howard Y Chang, Jesse R Dixon, Anindya Bagchi, Aniruddha J Deshpande, Hannah Carter, Ernest Fraenkel, Paul S Mischel, Robert J Wechsler-Reya, Vineet Bafna, Jill P Mesirov, Lukas Chavez
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Nature genetics (2023)
Erik N Bergstrom, Jens Luebeck, Mia Petljak, Azhar Khandekar, Mark Barnes, Tongwu Zhang, Christopher D Steele, Nischalan Pillay, Maria Teresa Landi, Vineet Bafna, Paul S Mischel, Reuben Stewart Harris, Ludmil B Alexandrov
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA. Nature 602 (7897) (2022)
Imran Noorani, Paul S Mischel, Charles Swanton
Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges. Nature reviews. Clinical oncology 19 (11) (2022)
King L Hung, Paul S Mischel, Howard Y Chang
Gene regulation on extrachromosomal DNA. Nature structural & molecular biology 29 (8) (2022)
Lauren T Pecorino, Roel G W Verhaak, Anton Henssen, Paul S Mischel
Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance. Biochemical Society transactions (2022)
King L Hung, Jens Luebeck, Siavash R Dehkordi, Caterina I Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H Lomeli, Natasha E Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E Houlahan, Wenting Yang, Rocio Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G Henssen, Julie A Law, William J Greenleaf, Roger S Lo, Paul S Mischel, Vineet Bafna, Howard Y Chang
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. Nature genetics 54 (11) (2022)
Paul S Mischel, Vineet Bafna
Form follows function in cancer genomes. Nature cancer 3 (8) (2022)
Joshua T Lange, John C Rose, Celine Y Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L Hung, Kathryn E Yost, Quanming Shi, Marcella L Erb, Utkrisht Rajkumar, Sihan Wu, Sabine Taschner-Mandl, Marie Bernkopf, Charles Swanton, Zhe J Liu, Weini Huang, Howard Y Chang, Vineet Bafna, Anton G Henssen, Benjamin Werner, Paul S Mischel
The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature genetics 54 (10) (2022)
John Pang, Nam-Phuong Nguyen, Jens Luebeck, Laurel Ball, Andrey Finegersh, Shuling Ren, Takuya Nakagawa, Mitchell Flagg, Sayed Sadat, Paul S Mischel, Guorong Xu, Kathleen M Fisch, Theresa W Guo, Gabrielle Cahill, Bharat Panuganti, Vineet Bafna, Joseph Califano
Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription. Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Mathieu F Bakhoum, Jasmine H Francis, Albert S Agustinus, Ethan M Earlie, Melody DiBona, David H Abramson, Mercedes Duran, Ignas Masilionis, Elsa Molina, Alexander N Shoushtari, Michael H Goldbaum, Paul S Mischel, Samuel F Bakhoum, Ashley M Laughney
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression. Nature communications 12 (1) (2021)
King L Hung, Kathryn E Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer, Jens Luebeck, Robert Schöpflin, Joshua T Lange, Rocio Chamorro González, Natasha E Weiser, Celine Y Chen, Maria E Stefanova, Ivy Tsz-Lo Wong, Sihan Wu, Siavash R Dehkordi, Connor V Duffy, Katerina Kraft, Jun Tang, Julia A Belk, John C Rose, M Ryan Corces, Jeffrey M Granja, Rui Li, Utkrisht Rajkumar, Jordan Friedlein, Anindya Bagchi, Ansuman T Satpathy, Robert Tjian, Stefan Mundlos, Vineet Bafna, Anton G Henssen, Paul S Mischel, Zhe J Liu, Howard Y Chang
ecDNA hubs drive cooperative intermolecular oncogene expression. Nature (2021)
Mathieu F Bakhoum, Ellis J Curtis, Michael H Goldbaum, Paul S Mischel
BAP1 methylation: a prognostic marker of uveal melanoma metastasis. NPJ precision oncology 5 (1) (2021)
Xiuxing Wang, Kailin Yang, Qiulian Wu, Leo J Y Kim, Andrew R Morton, Ryan N Gimple, Briana C Prager, Yu Shi, Wenchao Zhou, Shruti Bhargava, Zhe Zhu, Li Jiang, Weiwei Tao, Zhixin Qiu, Linjie Zhao, Guoxing Zhang, Xiqing Li, Sameer Agnihotri, Paul S Mischel, Stephen C Mack, Shideng Bao, Jeremy N Rich
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells. Science translational medicine 11 (504) (2020)
Tomoyuki Koga, Isaac A Chaim, Jorge A Benitez, Sebastian Markmiller, Alison D Parisian, Robert F Hevner, Kristen M Turner, Florian M Hessenauer, Matteo D'Antonio, Nam-Phuong D Nguyen, Shahram Saberi, Jianhui Ma, Shunichiro Miki, Antonia D Boyer, John Ravits, Kelly A Frazer, Vineet Bafna, Clark C Chen, Paul S Mischel, Gene W Yeo, Frank B Furnari
Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nature communications 11 (1) (2020)
Hoon Kim, Nam-Phuong Nguyen, Kristen Turner, Sihan Wu, Amit D Gujar, Jens Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi, Samirkumar B Amin, Eunhee Yi, Francesca Menghi, Johannes H Schulte, Anton G Henssen, Howard Y Chang, Christine R Beck, Paul S Mischel, Vineet Bafna, Roel G W Verhaak
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers. Nature genetics 52 (9) (2020)
Jens Luebeck, Ceyda Coruh, Siavash R Dehkordi, Joshua T Lange, Kristen M Turner, Viraj Deshpande, Dave A Pai, Chao Zhang, Utkrisht Rajkumar, Julie A Law, Paul S Mischel, Vineet Bafna
AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications. Nature communications 11 (1) (2020)
Tomoyuki Koga, Isaac A Chaim, Jorge A Benitez, Sebastian Markmiller, Alison D Parisian, Robert F Hevner, Kristen M Turner, Florian M Hessenauer, Matteo D'Antonio, Nam-Phuong D Nguyen, Shahram Saberi, Jianhui Ma, Shunichiro Miki, Antonia D Boyer, John Ravits, Kelly A Frazer, Vineet Bafna, Clark C Chen, Paul S Mischel, Gene W Yeo, Frank B Furnari
Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells. Nature communications 11 (1) (2020)
Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Karakida Kawaguchi, Yuki Sugiura, Oltea Sampetrean, Yoshiki Ikeda, Mikako Warren, Naoya Sakamoto, Shuji Kitahara, Hirofumi Yoshino, Daisuke Yamashita, Kazutaka Sumita, Kara Wolfe, Lisa Lange, Satsuki Ikeda, Hiroko Shimada, Noriaki Minami, Akshiv Malhotra, Shin Morioka, Yuki Ban, Maya Asano, Victoria L Flanary, Annmarie Ramkissoon, Lionel M L Chow, Juri Kiyokawa, Tomoyuki Mashimo, Greg Lucey, Sergey Mareninov, Tatsuya Ozawa, Nobuyuki Onishi, Koichi Okumura, Jumpei Terakawa, Takiko Daikoku, Trisha Wise-Draper, Nazanin Majd, Kaori Kofuji, Mika Sasaki, Masaru Mori, Yonehiro Kanemura, Eric P Smith, Dimitrios Anastasiou, Hiroaki Wakimoto, Eric C Holland, William H Yong, Craig Horbinski, Ichiro Nakano, Ralph J DeBerardinis, Robert M Bachoo, Paul S Mischel, Wataru Yasui, Makoto Suematsu, Hideyuki Saya, Tomoyoshi Soga, Ingrid Grummt, Holger Bierhoff, Atsuo T Sasaki
IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nature cell biology 21 (8) (2019)
Junfeng Bi, Sudhir Chowdhry, Sihan Wu, Wenjing Zhang, Kenta Masui, Paul S Mischel
Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets. Nature reviews. Cancer 20 (1) (2019)
Roel G W Verhaak, Vineet Bafna, Paul S Mischel
Extrachromosomal oncogene amplification in tumour pathogenesis and evolution. Nature reviews. Cancer 19 (5) (2019)