Anti-citrullinated peptide antibodies are the strongest predictor of clinically relevant radiographic progression in rheumatoid arthritis patients achieving remission or low disease activity: A post hoc analysis of a nationwide cohort in Japan.
Tomohiro KogaAkitomo OkadaTakaaki FukudaToshihiko HidakaTomonori IshiiYukitaka UekiTakao KoderaMunetoshi NakashimaYuichi TakahashiSeiyo HondaYoshiro HoraiRyu WatanabeHiroshi OkunoToshiyuki AramakiTomomasa IzumiyamaOsamu TakaiTaiichiro MiyashitaShuntaro SatoShin-Ya KawashiriNaoki IwamotoKunihiro IchinoseMami TamaiTomoki OriguchiHideki NakamuraKiyoshi AoyagiKatsumi EguchiAtsushi Kawakaminull nullPublished in: PloS one (2017)
ACPA positivity was the strongest independent predictor of CRRP in patients with RA in remission or LDA. Physicians should recognize ACPA as a poor-prognosis factor regarding the radiographic outcome of RA, even among patients showing a clinically favorable response to DMARDs.