PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes.
Angel BottiniDennis J WuRizi AiMichelle Le RouxBeatrix BartokMichele BombardieriKaren M DoodyVida ZhangCristiano SacchettiMartina ZocchedduAna LonicXiaochun LiDavid L BoyleDeepa HammakerTzu-Ching MengLin LiuMaripat CorrStephanie M StanfordMyles J LewisWei WangGary S FiresteinYeesim Khew-GoodallCostantino PitzalisNunzio BottiniPublished in: Annals of the rheumatic diseases (2019)
In RA FLS, PTPN14 and YAP promote nuclear localisation of SMAD3. YAP enhances a range of RA FLS pathogenic behaviours which, together with epigenetic evidence, points to the Hippo pathway as an important regulator of RA FLS behaviour.