Transcriptomic analyses of the anti-adipogenic effects of oleuropein in human mesenchymal stem cells.
José Manuel Quesada-GomezJaouad AnterSören MüllerPeter WinterJosé Manuel Quesada-GómezGabriel DoradoPublished in: Food & function (2017)
Extra virgin olive oil has positive effects on health. Oleuropein is a polyphenolic compound present in olive-tree leaves, fruits (olives) and olive oil. It is responsible for the relevant organoleptic and biological properties of olive oil, including antiadipogenic properties. Thus, the effects of oleuropein on the adipogenesis of human bone-marrow mesenchymal stem cells were studied by transcriptomics and differential gene-expression analyses. Oleuropein could upregulate expression of 60% of adipogenesis-repressed genes. Besides, it could activate signaling pathways such as Rho and β-catenin, maintaining cells at an undifferentiated stage. Our data suggest that mitochondrial activity is reduced by oleuropein, mostly during adipogenic differentiation. These results shed light on oleuropein activity on cells, with potential application as a "nutraceutical" for the prevention and treatment of diseases such as obesity and osteoporosis.
Keyphrases
- induced apoptosis
- gene expression
- endothelial cells
- mesenchymal stem cells
- cell cycle arrest
- signaling pathway
- oxidative stress
- high fat diet induced
- healthcare
- single cell
- public health
- type diabetes
- metabolic syndrome
- fatty acid
- pluripotent stem cells
- insulin resistance
- endoplasmic reticulum stress
- poor prognosis
- dna methylation
- postmenopausal women
- mental health
- weight loss
- stem cells
- pi k akt
- cell death
- risk assessment
- bone marrow
- transcription factor
- climate change
- skeletal muscle
- binding protein
- adipose tissue
- weight gain
- deep learning
- smooth muscle
- genome wide analysis