A benchmark of computational methods for correcting biases of established and unknown origin in CRISPR-Cas9 screening data.

Alessandro Vinceti Raffaele M Iannuzzi Isabella Boyle Lucia Trastulla Catarina D Campbell Francisca Vazquez Joshua M Dempster Francesco Iorio

Published in: Genome biology (2024)

Overall, our investigation provides guidance for the selection of the most appropriate bias-correction method, based on its strengths, weaknesses and experimental settings.

Keyphrases

crispr cas
genome editing
electronic health record
big data
data analysis