Biomarkers of treatment success in fully sensitive pulmonary tuberculosis patients: a multicenter longitudinal study.
Vladyslav NikolayevskyyYanina BalabanovaIrina KontsevayaOlga IgnatyevaGirts SkendersEdita VasiliauskieneDavid van BockelFrancis DrobniewskiPublished in: Biomarkers in medicine (2020)
Aim: Novel biomarkers that are able to accurately monitor tuberculosis (TB) treatment effectiveness are needed to adjust therapy and identify a need for a regimen change. Materials & methods: In our study, conducted on a cohort comprising 100 pulmonary TB patients, we analyzed the role of plasma cytokines and Toll-like receptors expression as biomarkers of treatment response. Results: Changes in toll-interacting protein (TOLLIP) and lymphocyte antigen 96 (LY96) gene expression as well as nine cytokine levels over the first 2 months were significantly associated with successful treatment outcome. Successful treatment was associated with higher serum concentration of Toll-like receptor-2. Conclusion: Our results suggest that differential expression of specific effector molecules and dynamics of selected cytokines may help to identify those responding to TB treatment early.
Keyphrases
- mycobacterium tuberculosis
- toll like receptor
- pulmonary tuberculosis
- gene expression
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- randomized controlled trial
- prognostic factors
- inflammatory response
- systematic review
- immune response
- poor prognosis
- small molecule
- patient reported outcomes
- cross sectional
- clinical trial
- pulmonary hypertension
- mesenchymal stem cells
- peripheral blood
- nuclear factor
- hiv aids
- patient reported
- hiv infected
- smoking cessation