Randomized Phase II Study of Physiologic MRI-Directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer.
Michelle Lynn MierzwaMadhava AryalChoonik LeeMatthew J SchipperMonica VanTilKrystal MoralesPaul L SwiecickiKeith A CasperKelly M MalloyMatthew E SpectorAndrew G ShumanSteven Bennett ChinnMark E P PrinceChaz L StuckenAndrew J RoskoTheodore S LawrenceJohn Chad BrennerBenjamin S RosenCaitlin A SchonewolfJennifer L ShahAvraham EisbruchFrancis P WordenYue CaoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Physiologic MRI-based RT boost decreased LRF without a significant increase in grade 3+ toxicity or longitudinal PRO differences, but did not significantly improve DFS or OS. Additional improvements in systemic therapy are likely necessary to realize improvements in DFS and OS.
Keyphrases
- poor prognosis
- phase ii study
- open label
- long non coding rna
- contrast enhanced
- placebo controlled
- magnetic resonance imaging
- double blind
- diffusion weighted imaging
- phase iii
- locally advanced
- phase ii
- oxidative stress
- cross sectional
- computed tomography
- squamous cell carcinoma
- randomized controlled trial
- magnetic resonance
- bone marrow
- radiation therapy
- mesenchymal stem cells
- cell therapy
- drug induced