Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts.
Takuya OkamotoFumie NakashimaTakahiro ShibataDaisuke MoriPublished in: Bioscience, biotechnology, and biochemistry (2024)
Seabuckthorn pulp oil (SBO) is used in beauty products because of its rich lipophilic substances with high nutraceutical and cosmeceutical potential. However, the mechanism through which SBO enhances skin elasticity remains unclear. Therefore, in this study, we examined the anti-photoaging activity of SBO in normal human dermal fibroblasts (NHDF) under ultraviolet (UV) irradiation. Pretreatment with SBO significantly suppressed UV-B-induced cell toxicity and collagen degradation, suggesting that SBO contains anti-photoaging substances. Further, palmitoleic acid, the main component of SBO, maintained cell viability and collagen levels in UV-B-irradiated NHDF by suppressing the expression of matrix metalloproteinase 1 and acted on the inhibition of p38 and JNK phosphorylation and nuclear translocation of nuclear factor-kappa B. These findings suggest the utility of SBO as an anti-photoaging agent.
Keyphrases
- nuclear factor
- endothelial cells
- high glucose
- toll like receptor
- wound healing
- diabetic rats
- oxidative stress
- induced pluripotent stem cells
- poor prognosis
- single cell
- drug induced
- cell death
- stem cells
- fatty acid
- pluripotent stem cells
- extracellular matrix
- radiation therapy
- immune response
- bone marrow
- mouse model
- long non coding rna
- binding protein
- human health