Randomised clinical study: inulin short-chain fatty acid esters for targeted delivery of short-chain fatty acids to the human colon.

T PolyviouK MacDougallE S ChambersA ViardotA PsichasS JawaidH C HarrisC A EdwardsL SimpsonK G MurphyS E K Zac-VargheseJ E BlundellW S DhilloS R BloomG S FrostT PrestonM C TedfordDouglas J Morrison

Published in: Alimentary pharmacology & therapeutics (2016)

IPE-27 significantly reduced food intake suggesting colonic propionate plays a role in appetite regulation. Inulin short-chain fatty acid esters provide a novel tool for probing the diet-gut microbiome-host metabolism axis in humans.

Keyphrases

fatty acid
weight loss
endothelial cells
double blind
clinical trial
open label
physical activity
induced pluripotent stem cells
study protocol
placebo controlled
molecular dynamics simulations
pluripotent stem cells
single molecule
randomized controlled trial
ulcerative colitis