Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia.
Andrew J MonteithHaley E RamseyAlexander James SilverDonovan J BrownDalton L GreenwoodBrianna N SmithAshley D WiseJuan LiuSarah D OlmsteadJackson WatkeMaria P ArrateAgnieszka E GorskaLonda FullerJason W LocasaleMatthew C StubbsJeffrey C RathmellMichael R SavonaPublished in: Cancer research (2024)
Lactate utilization allows AML myeloblasts to maintain metabolic integrity and circumvent antileukemic therapy, which supports testing of lactate utilization inhibitors in clinical settings to overcome BET inhibitor resistance in AML. See related commentary by Boët and Sarry, p. 950.