Immunodominant MHC-II (Major Histocompatibility Complex II) Restricted Epitopes in Human Apolipoprotein B.
Payel RoyJohn SidneyCecilia S Lindestam ArlehamnElizabeth PhillipsSimon A MallalSujit Silas Armstrong SuthaharMonica BillittiPaul RubiroDaniel MarramaFabrizio DragoJenifer VallejoVasantika SuryawanshiMarco OrecchioniJeffrey MakingsPaul J KimColeen A McNamaraBjoern PetersAlessandro SetteKlaus LeyPublished in: Circulation research (2022)
Using 3 cohorts, each with ≈20 donors, we discovered and validated 6 immunodominant, HLA-II-restricted APOB epitopes. The immune response to these APOB epitopes correlated with coronary artery disease severity.