Evaluation of stroke incidence with duty-cycled multielectrode-phased radiofrequency ablation of persistent atrial fibrillation results of the VICTORY AF Study.
John D HummelAtul VermaHugh CalkinsLee S SchwammDaryl GressDarryl WellsJoseph SouzaRobert B HokansonLauren HemingwayKurt StrombergRobert HoytAndrew WickliffeDavid DeLurgioLucas BoersmaPublished in: Journal of cardiovascular electrophysiology (2020)
VICTORY AF demonstrated a 1.6% incidence of stroke in PersAF undergoing ablation with a phased RF system which did not meet statistical confidence due to poor enrollment. The secondary outcomes suggest comparable efficacy to phased RF in the tailored treatment of permanent AF trial. Rigorous clinical evaluation of the stroke risk of new AF ablation technologies as well as restriction to Vitamin K antagonist anticoagulation appears to be unachievable goals in a clinical multicenter IDE trial of AF ablation in the current era.
Keyphrases
- atrial fibrillation
- catheter ablation
- radiofrequency ablation
- left atrial
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- risk factors
- percutaneous coronary intervention
- clinical trial
- phase iii
- study protocol
- phase ii
- healthcare
- metabolic syndrome
- randomized controlled trial
- adipose tissue
- cross sectional
- open label
- insulin resistance
- global health