Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis.
Ila DatarMiguel F SanmamedJun WangBrian S HenickJungmin ChoiTi BadriWeilai DongNikita ManiMaria TokiLuis D MejíasMaria D LozanoJose Luis Perez-GraciaVamsidhar VelchetiMatthew D HellmannJustin F GainorKristen McEachernDavid JenkinsKonstantinos SyrigosKaterina PolitiScott GettingerDavid L RimmRoy S HerbstIgnacio MeleroLieping ChenKurt A SchalperPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
PD-1, LAG-3, and TIM-3 have distinct tissue/cell distribution, functional implications, and genomic correlates in human NSCLC. Expression of these immune inhibitory receptors in TILs is associated with prominent activation, but also with a proapoptotic T-cell phenotype. Elevated LAG-3 expression is associated with insensitivity to PD-1 axis blockade, suggesting independence of these immune evasion pathways.