Effectiveness of mRNA COVID-19 Vaccines as First Booster Doses in England: An Observational Study in OpenSAFELY-TPP.

Elsie M F Horne William J HulmeEdward P K ParkerRuth H Keogh Elizabeth J Williamson Venexia M Walker Tom M PalmerRachel DenholmRochelle Knight Helen J Curtis Alex J Walker Colm D Andrews Amir Mehrkar Jessica Morley Brian Mackenna Sebastian C J Bacon Alex J Walker Miguel A Hernán Jonathan A C Sternenull null

Published in: Epidemiology (Cambridge, Mass.) (2024)

We estimate that COVID-19 booster vaccination, compared with no booster vaccination, provided substantial protection against COVID-19 hospitalization and COVID-19 death but only limited protection against positive SARS-CoV-2 test. Lower rates of fracture in boosted than unboosted individuals may suggest unmeasured confounding. Observational studies should report estimated vaccine effectiveness against nontarget and negative control outcomes.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
randomized controlled trial
systematic review
adipose tissue