Nlrp3, Csf3, and Edn1 in Macrophage Response to Saturated Fatty Acids and Modified Low-Density Lipoprotein.
Harin YoukMiso KimChan Joo LeeJaewon OhChan Joo LeeSeok-Min KangJeong Ho KimSoo Jin AnnSang-Hak LeePublished in: Korean circulation journal (2020)
We demonstrated that the proinflammatory milieu with high levels of PA or mmLDL promoted macrophage activation and the expression of associated genes such as Nlrp3, Csf3, and Edn1. Although the TLR4 pathway appeared to be most relevant, additional role of other genes in this process provided insights regarding the potential targets for intervention.
Keyphrases
- low density lipoprotein
- genome wide
- fatty acid
- adipose tissue
- poor prognosis
- randomized controlled trial
- bioinformatics analysis
- genome wide identification
- toll like receptor
- nlrp inflammasome
- inflammatory response
- cerebrospinal fluid
- dna methylation
- risk assessment
- binding protein
- gene expression
- human health
- nuclear factor