Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs).
Qisi ZhangCyrille S KoundeMilon MondalJake L GreenfieldJennifer R BakerSergei KotelnikovMikhail IgnatovChristopher P TinworthLeran ZhangDaniel ConoleElena De VitaDima KozakovAdam McCluskeyJohn D HarlingMatthew John FuchterEdward William TatePublished in: Chemical communications (Cambridge, England) (2022)
Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.