Edward William Tate (Edward W Tate)

Ciência ID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 88

Top Venues

Journal of medicinal chemistry

Nature communications

Antimicrobial agents and chemotherapy

RSC chemical biology

Imperial College London

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Imperial College London May 01 2004

United Kingdom

Professor of Chemical Biology :: Chemistry

Publications

Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry (2024)
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry 67 (2) (2024)
Rishi R Shah, Elena De Vita, Preethi S Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R Dickinson, Carlos M Fleites, Markus A Queisser, John D Harling, Edward William Tate
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. Journal of medicinal chemistry (2024)
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry 67 (2) (2024)
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry 67 (2) (2024)
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry 67 (2) (2024)
Rishi R Shah, Elena De Vita, Preethi S Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R Dickinson, Carlos M Fleites, Markus A Queisser, John D Harling, Edward William Tate
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. Journal of medicinal chemistry 67 (6) (2024)
Yusman Manchanda, Liliane ElEid, Affiong I Oqua, Zenouska Ramchunder, Jiyoon Choi, Maria M Shchepinova, Guy A Rutter, Asuka Inoue, Edward William Tate, Ben J Jones, Alejandra Tomas
Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling. Science signaling 17 (843) (2024)
Simeon D Draganov, Michael J Gruet, Daniel Conole, Cristina Balcells, Alexandros P Siskos, Hector C Keun, Dorian O Haskard, Edward William Tate
Chemical tools for profiling the intracellular ADP-ribosylated proteome. RSC chemical biology 5 (7) (2024)
Edward William Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang, Hening Lin
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets. Nature reviews. Cancer (2024)
Cory A Ocasio, Marc P Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M Storck, Jack W Houghton, Susana A Palma-Duran, James I MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S Eggert, Edward William Tate
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature biotechnology (2024)
Rishi R Shah, Elena De Vita, Preethi S Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R Dickinson, Carlos M Fleites, Markus A Queisser, John D Harling, Edward William Tate
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. Journal of medicinal chemistry 67 (6) (2024)
Milon Mondal, Fangyuan Cao, Daniel Conole, Holger W Auner, Edward William Tate
Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30. RSC chemical biology 5 (5) (2024)
Rishi R Shah, Elena De Vita, Preethi S Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R Dickinson, Carlos M Fleites, Markus A Queisser, John D Harling, Edward William Tate
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. Journal of medicinal chemistry 67 (6) (2024)
Simeon D Draganov, Michael J Gruet, Daniel Conole, Cristina Balcells, Alexandros P Siskos, Hector C Keun, Dorian O Haskard, Edward William Tate
Chemical tools for profiling the intracellular ADP-ribosylated proteome. RSC chemical biology 5 (7) (2024)
Rishi R Shah, Elena De Vita, Preethi S Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R Dickinson, Carlos M Fleites, Markus A Queisser, John D Harling, Edward William Tate
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. Journal of medicinal chemistry 67 (6) (2024)
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry 67 (2) (2024)
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry 67 (2) (2024)
Cory A Ocasio, Marc P Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M Storck, Jack W Houghton, Susana A Palma-Duran, James I MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S Eggert, Edward William Tate
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature biotechnology (2024)
Rishi R Shah, Elena De Vita, Preethi S Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R Dickinson, Carlos M Fleites, Markus A Queisser, John D Harling, Edward William Tate
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs. Journal of medicinal chemistry 67 (6) (2024)
Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A Andrei, Olivia Boyd, Naoko Masumoto, Ursula R Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I Raynaud, Rosemary Burke, Julian Blagg, Henry S Rzepa, Christian Siebold, Anthony I Magee, Thomas Lanyon-Hogg, Edward William Tate
Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase. Journal of medicinal chemistry 67 (2) (2024)
Edward William Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang, Hening Lin
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets. Nature reviews. Cancer 24 (4) (2024)
Edward William Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang, Hening Lin
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets. Nature reviews. Cancer 24 (4) (2024)
Milon Mondal, Fangyuan Cao, Daniel Conole, Holger W Auner, Edward William Tate
Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30. RSC chemical biology 5 (5) (2024)
Cory A Ocasio, Marc P Baggelaar, James Sipthorp, Ana Losada de la Lastra, Manuel Tavares, Jana Volarić, Christelle Soudy, Elisabeth M Storck, Jack W Houghton, Susana A Palma-Duran, James I MacRae, Goran Tomić, Lotte Carr, Julian Downward, Ulrike S Eggert, Edward William Tate
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. Nature biotechnology (2024)
Edward William Tate, Lior Soday, Ana Losada de la Lastra, Mei Wang, Hening Lin
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets. Nature reviews. Cancer 24 (4) (2024)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Elizabeth V K Ledger, Katie Lau, Edward William Tate, Andrew M Edwards
XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus. Antimicrobial agents and chemotherapy 67 (3) (2023)
Emma C Couves, Scott Gardner, Tomas B Voisin, Jasmine K Bickel, Phillip J Stansfeld, Edward William Tate, Doryen Bubeck
Structural basis for membrane attack complex inhibition by CD59. Nature communications 14 (1) (2023)
Elizabeth V K Ledger, Katie Lau, Edward William Tate, Andrew M Edwards
XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus. Antimicrobial agents and chemotherapy 67 (3) (2023)
Emma C Couves, Scott Gardner, Tomas B Voisin, Jasmine K Bickel, Phillip J Stansfeld, Edward William Tate, Doryen Bubeck
Structural basis for membrane attack complex inhibition by CD59. Nature communications 14 (1) (2023)
Emma C Couves, Scott Gardner, Tomas B Voisin, Jasmine K Bickel, Phillip J Stansfeld, Edward William Tate, Doryen Bubeck
Structural basis for membrane attack complex inhibition by CD59. Nature communications 14 (1) (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Emma C Couves, Scott Gardner, Tomas B Voisin, Jasmine K Bickel, Phillip J Stansfeld, Edward William Tate, Doryen Bubeck
Structural basis for membrane attack complex inhibition by CD59. Nature communications 14 (1) (2023)
Elizabeth V K Ledger, Katie Lau, Edward William Tate, Andrew M Edwards
XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus. Antimicrobial agents and chemotherapy 67 (3) (2023)
Elizabeth V K Ledger, Katie Lau, Edward William Tate, Andrew M Edwards
XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus. Antimicrobial agents and chemotherapy (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Domhnall McHugh, Bin Sun, Carmen Gutierrez-Muñoz, Fernanda Hernández-González, Massimiliano Mellone, Romain Guiho, Imanol Duran, Joaquim Pombo, Federico Pietrocola, Jodie Birch, Wouter W Kallemeijn, Sanjay Khadayate, Gopuraja Dharmalingam, Santiago Vernia, Edward William Tate, Juan Pedro Martínez-Barbera, Dominic J Withers, Gareth J Thomas, Manuel Serrano, Jesús Gil
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells. Nature cell biology (2023)
Emma C Couves, Scott Gardner, Tomas B Voisin, Jasmine K Bickel, Phillip J Stansfeld, Edward William Tate, Doryen Bubeck
Structural basis for membrane attack complex inhibition by CD59. Nature communications 14 (1) (2023)
Roman O Fedoryshchak, Andrii Gorelik, Mengjie Shen, Maria M Shchepinova, Inmaculada Pérez-Dorado, Edward William Tate
Discovery of lipid-mediated protein-protein interactions in living cells using metabolic labeling with photoactivatable clickable probes. Chemical science 14 (9) (2023)
Roman O Fedoryshchak, Andrii Gorelik, Mengjie Shen, Maria M Shchepinova, Inmaculada Pérez-Dorado, Edward William Tate
Discovery of lipid-mediated protein-protein interactions in living cells using metabolic labeling with photoactivatable clickable probes. Chemical science 14 (9) (2023)
Elizabeth V K Ledger, Katie Lau, Edward William Tate, Andrew M Edwards
XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus. Antimicrobial agents and chemotherapy (2023)
Emma C Couves, Scott Gardner, Tomas B Voisin, Jasmine K Bickel, Phillip J Stansfeld, Edward William Tate, Doryen Bubeck
Structural basis for membrane attack complex inhibition by CD59. Nature communications 14 (1) (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Sabrina Yahiya, Charlie N Saunders, Sarah Hassan, Ursula Straschil, Oliver J Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J Delves, Edward William Tate, Anna Barnard, Matthew John Fuchter, Jake Baum
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease models & mechanisms 16 (2) (2023)
Emma C Couves, Scott Gardner, Tomas B Voisin, Jasmine K Bickel, Phillip J Stansfeld, Edward William Tate, Doryen Bubeck
Structural basis for membrane attack complex inhibition by CD59. Nature communications 14 (1) (2023)
Elizabeth V K Ledger, Katie Lau, Edward William Tate, Andrew M Edwards
XerC Is Required for the Repair of Antibiotic- and Immune-Mediated DNA Damage in Staphylococcus aureus. Antimicrobial agents and chemotherapy 67 (3) (2023)
Qisi Zhang, Cyrille S Kounde, Milon Mondal, Jake L Greenfield, Jennifer R Baker, Sergei Kotelnikov, Mikhail Ignatov, Christopher P Tinworth, Leran Zhang, Daniel Conole, Elena De Vita, Dima Kozakov, Adam McCluskey, John D Harling, Matthew John Fuchter, Edward William Tate
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs). Chemical communications (Cambridge, England) 58 (78) (2022)
Elena De Vita, Daniel Lucy, Edward William Tate
Beyond targeted protein degradation: LD·ATTECs clear cellular lipid droplets. Cell research 31 (9) (2022)
Leran Zhang, Scott Lovell, Elena De Vita, Pravin Kumar Ankush Jagtap, Daniel Lucy, Andrea Goya Grocin, Svend Kjær, Annabel Borg, Janosch Hennig, Aubry K Miller, Edward William Tate
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion. Journal of the American Chemical Society (2022)
Scott Lovell, Leran Zhang, Thomas Kryza, Anna Neodo, Nathalie Bock, Elena De Vita, Elizabeth D Williams, Elisabeth Engelsberger, Congyi Xu, Alexander T Bakker, Marı A Maneiro, Reiko J Tanaka, Charlotte Lynne Bevan, Judith A Clements, Edward William Tate
A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer. Journal of the American Chemical Society 143 (23) (2021)
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield, Joshua Newington, Matthew John Fuchter, Anthony I Magee, Christian Siebold, Edward William Tate
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*. Angewandte Chemie (International ed. in English) 60 (24) (2021)
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield, Joshua Newington, Matthew John Fuchter, Anthony I Magee, Christian Siebold, Edward William Tate
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT). Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (24) (2021)
Mostafa Jamshidiha, Thomas Lanyon-Hogg, Charlotte L Sutherell, Gregory B Craven, Montse Tersa, Elena De Vita, Delia Brustur, Inmaculada Pérez-Dorado, Sarah Hassan, Rita Petracca, Rhodri M Morgan, Máximo Sanz-Hernández, Jim C Norman, Alan Armstrong, David J Mann, Ernesto Cota, Edward William Tate
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. RSC medicinal chemistry 13 (2) (2021)
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield, Joshua Newington, Matthew John Fuchter, Anthony I Magee, Christian Siebold, Edward William Tate
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT). Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (24) (2021)
Daniel Paolo Anderson, Henry James Benns, Edward William Tate, Matthew Andrew Child
CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering. Molecular systems biology 16 (6) (2021)
Thomas Kryza, Tashbib Khan, Scott Lovell, Brittney S Harrington, Julia X Yin, Sean Porazinski, Marina Pajic, Hannu Koistinen, Juha K Rantala, Tobias Dreyer, Viktor Magdolen, Ute Reuning, Yaowu He, Edward William Tate, John D Hooper
Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1. Nature chemical biology 17 (7) (2021)
Nattawadee Panyain, Aurélien Godinat, Aditya Raymond Thawani, Sofia Lachiondo-Ortega, Katie Mason, Sarah Elkhalifa, Lisa M Smith, Jeanine A Harrigan, Edward William Tate
Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe. RSC medicinal chemistry 12 (11) (2021)
Milon Mondal, Daniel Conole, Jaya Nautiyal, Edward William Tate
UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology. British journal of cancer (2021)
Wouter W Kallemeijn, Thomas Lanyon-Hogg, Nattawadee Panyain, Andrea Goya Grocin, Paulina Ciepla, Julia Morales-Sanfrutos, Edward William Tate
Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation. Nature protocols 16 (11) (2021)
Cassandra R Kennedy, Andrea Goya Grocin, Tristan Kovačič, Ravi Singh, Jennifer A Ward, Avinash R Shenoy, Edward William Tate
A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS chemical biology 16 (6) (2021)
Cyrille S Kounde, Maria M Shchepinova, Charlie N Saunders, Marcel Muelbaier, Mark D Rackham, John D Harling, Edward William Tate
A caged E3 ligase ligand for PROTAC-mediated protein degradation with light. Chemical communications (Cambridge, England) 56 (41) (2020)
Andrew S Bell, Zhiyong Yu, Jennie A Hutton, Megan H Wright, James A Brannigan, Daniel Paape, Shirley M Roberts, Charlotte L Sutherell, Markus Ritzefeld, Anthony J Wilkinson, Deborah F Smith, Robin J Leatherbarrow, Edward William Tate
Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes. Journal of medicinal chemistry 63 (14) (2020)
Nattawadee Panyain, Aurélien Godinat, Thomas Lanyon-Hogg, Sofía Lachiondo-Ortega, Edward J Will, Christelle Soudy, Milon Mondal, Katie Mason, Sarah Elkhalifa, Lisa M Smith, Jeanine A Harrigan, Edward William Tate
Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity". Journal of the American Chemical Society 142 (35) (2020)
Camilla T O Benfield, Farrell MacKenzie, Markus Ritzefeld, Michela Mazzon, Stuart Weston, Edward William Tate, Boon Han Teo, Sarah E Smith, Paul Kellam, Edward C Holmes, Mark Marsh
Correction: Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain. Life science alliance 3 (6) (2020)
Cyril Dian, Inmaculada Pérez-Dorado, Frédéric Rivière, Thomas Asensio, Pierre Legrand, Markus Ritzefeld, Mengjie Shen, Ernesto Cota, Thierry Meinnel, Edward William Tate, Carmela Giglione
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nature communications 11 (1) (2020)
Noura Alzahofi, Tobias Welz, Christopher L Robinson, Emma L Page, Deborah A Briggs, Amy K Stainthorp, James Reekes, David A Elbe, Felix Straub, Wouter W Kallemeijn, Edward William Tate, Philip S Goff, Elena V Sviderskaya, Marta Cantero, Lluís Montoliu, Francois Nedelec, Amanda K Miles, Maryse Bailly, Eugen Kerkhoff, Alistair N Hume
Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins. Nature communications 11 (1) (2020)
Jennifer A Ward, Adan Pinto-Fernandez, Loïc Cornelissen, Sarah Bonham, Laura Díaz-Sáez, Olivier Riant, Kilian V M Huber, Benedikt M Kessler, Olivier Feron, Edward William Tate
Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs. Journal of medicinal chemistry 63 (7) (2020)
Roman O Fedoryshchak, Cory A Ocasio, Benjamin Strutton, Jo Mattocks, Andrew J Corran, Edward William Tate
Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism. RSC chemical biology 1 (2) (2020)
Charlie N Saunders, Ernesto Cota, Jake Baum, Edward William Tate
Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex. ACS chemical biology 15 (6) (2020)
Nattawadee Panyain, Aurélien Godinat, Thomas Lanyon-Hogg, Sofía Lachiondo-Ortega, Edward J Will, Christelle Soudy, Milon Mondal, Katie Mason, Sarah Elkhalifa, Lisa M Smith, Jeanine A Harrigan, Edward William Tate
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity. Journal of the American Chemical Society 142 (28) (2020)
Marı A Maneiro, Nafsika Forte, Maria M Shchepinova, Cyrille S Kounde, Vijay Chudasama, James Richard Baker, Edward William Tate
Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS chemical biology 15 (6) (2020)
Bruno M Simões, Angélica Santiago-Gómez, Chiara Chiodo, Tiago Moreira, Daniel Conole, Scott Lovell, Denis Alferez, Rachel Eyre, Katherine Spence, Aida Sarmiento-Castro, Bertram Kohler, Ludivine Morisset, Marilena Lanzino, Sebastiano Andò, Elisabetta Marangoni, Andrew H Sims, Edward William Tate, Sacha J Howell, Robert B Clarke
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer. Oncogene 39 (25) (2020)
Cesira de Chiara, Miha Homšak, Gareth A Prosser, Holly L Douglas, Acely Garza-Garcia, Geoff Kelly, Andrew G Purkiss, Edward William Tate, Luiz Pedro Sorio de Carvalho
D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition. Nature chemical biology 16 (6) (2020)
Ryan T Howard, Paul Hemsley, Philip Petteruti, Charlie N Saunders, Javier A Molina Bermejo, James S Scott, Jeffrey W Johannes, Edward William Tate
Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS chemical biology 15 (2) (2020)
Cyrille S Kounde, Edward William Tate
Photoactive Bifunctional Degraders: Precision Tools To Regulate Protein Stability. Journal of medicinal chemistry 63 (24) (2020)
Ainoa Rueda-Zubiaurre, Sabrina Yahiya, Oliver J Fischer, Xiaojun Hu, Charlie N Saunders, Sachi Sharma, Ursula Straschil, Junting Shen, Edward William Tate, Michael J Delves, Jake Baum, Anna Barnard, Matthew John Fuchter
Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes. Journal of medicinal chemistry 63 (5) (2019)
Rhiannon Beard, David C A Gaboriau, Antony D Gee, Edward William Tate
Chemical biology tools for probing transcytosis at the blood-brain barrier. Chemical science 10 (46) (2019)
Camilla T O Benfield, Farrell MacKenzie, Markus Ritzefeld, Michela Mazzon, Stuart Weston, Edward William Tate, Boon Han Teo, Sarah E Smith, Paul Kellam, Edward C Holmes, Mark Marsh
Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain. Life science alliance 3 (1) (2019)
Elisabeth M Storck, Julia Morales-Sanfrutos, Remigiusz A Serwa, Nattawadee Panyain, Thomas Lanyon-Hogg, Tanya Tolmachova, Leandro N Ventimiglia, Juan Martin-Serrano, Miguel C Seabra, Beata Wojciak-Stothard, Edward William Tate
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics. Nature chemistry 11 (6) (2019)
Thomas Lanyon-Hogg, Markus Ritzefeld, Lea Sefer, Jasmine K Bickel, Amalie F Rudolf, Nattawadee Panyain, Ganka Bineva-Todd, Cory A Ocasio, Nicola J O'Reilly, Christian Siebold, Anthony I Magee, Edward William Tate
Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes. Chemical science 10 (39) (2019)
James R Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C Weaver, Claudia Von Arx, Manuela Mura, Aline T Marinho, Haonan Lu, Eloise V N Morecroft, Evdoxia Karali, Naomi E Chayen, Edward William Tate, Mollie Jurewicz, Lawrence J Stern, Chiara Recchi, Hani Gabra
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions. Nature communications 10 (1) (2019)
Gregory B Craven, Dominic P Affron, Charlotte E Allen, Stefan Matthies, Joe G Greener, Rhodri M L Morgan, Edward William Tate, Alan Armstrong, David J Mann
High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery. Angewandte Chemie (International ed. in English) 57 (19) (2018)
Aurélie Mousnier, Andrew S Bell, Dawid P Swieboda, Julia Morales-Sanfrutos, Inmaculada Pérez-Dorado, James A Brannigan, Joseph Newman, Markus Ritzefeld, Jennie A Hutton, Anabel Guedán, Amin S Asfor, Sean W Robinson, Iva Hopkins-Navratilova, Anthony J Wilkinson, Sebastian L Johnston, Robin J Leatherbarrow, Tobias J Tuthill, Roberto Solari, Edward William Tate
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nature chemistry 10 (6) (2018)
Zebin Wang, Shaun E Grosskurth, Tony Cheung, Philip Petteruti, Jingwen Zhang, Xin Wang, Wenxian Wang, Farzin Gharahdaghi, Jiaquan Wu, Nancy Su, Ryan T Howard, Michele Mayo, Dan Widzowski, David A Scott, Jeffrey W Johannes, Michelle L Lamb, Deborah Lawson, Jonathan R Dry, Paul D Lyne, Edward William Tate, Michael Zinda, Keith Mikule, Stephen E Fawell, Corinne Reimer, Huawei Chen
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer. Cancer research 78 (23) (2018)
Alexandra S Lubin, Ainoa Rueda-Zubiaurre, Holly Matthews, Hella Baumann, Fabio R Fisher, Julia Morales-Sanfrutos, Kate S Hadavizadeh, Flore Nardella, Edward William Tate, Jake Baum, Artur Scherf, Matthew John Fuchter
Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum. ACS infectious diseases 4 (4) (2018)
Anja C Schlott, Anthony A Holder, Edward William Tate
N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action. ACS infectious diseases 4 (4) (2018)
Elena De Vita, Peter Schüler, Scott Lovell, Jasmin Lohbeck, Sven Kullmann, Eitan Rabinovich, Amiram Sananes, Bernd Heßling, Veronique Hamon, Niv Papo, Jochen Hess, Edward William Tate, Nikolas Gunkel, Aubry K Miller
Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity. Journal of medicinal chemistry 61 (19) (2018)

Edward William Tate.css-eqlu8i{font-size:small;padding-left:4px;} (Edward W Tate)

Publication Activity (10 Years)

Top Topics

Top Venues

Edward William Tate (Edward W Tate)