Hypoxia-inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36.
Esther ReyFlorinda Meléndez-RodríguezPatricia MarañónMiriam Gil-ValleAlmudena G CarrascoMar Torres-CapelliStephania ChávezElvira Del Pozo-MarotoJavier Rodríguez de CíaJulián AragonésCarmelo García-MonzónÁgueda González-RodríguezPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
This study provides evidence that HIF2α drives lipid accumulation in human hepatocytes by upregulating CD36 expression and function, and could contribute to hepatosteatosis setup.